Pediatr. praxi. 2009;10(5):344-347

Conjugate vaccines in prevention of pneumococcal infections

MUDr. Jiří Slíva
Ústav farmakologie 3. LF UK, Praha

Undoubtedly, Streptococcus pneumoniae is one of the most important pathogens causing pneumonia, meningitis, otitis or sepsis

in children. Currently, there are two types of conjugate vaccines used as a prophylaxis in the Czech Republic – Prevenar and Synflorix.

The article summarizes so far published data on their efficacy and safety.

Keywords: conjugate vaccines, Streptococcus pneumoniae, otitis media, pneumonia, meningitis, sepsis.

Published: December 1, 2009  Show citation

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Slíva J. Conjugate vaccines in prevention of pneumococcal infections. Pediatr. praxi. 2009;10(5):344-347.
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    References

    1. Recommendation for the production and control of pneumococcal conjugate vaccines. World Health Organization Technical Report Series 2005.
    2. WHO/Health Canada Consultation on Serological Criteria for Evaluation and Licensing of New Pneumococcal Vaccines. WHO 2008.
    3. Lee H, Nahm MH, Burton R, Kim KH. Immune response in infants to the heptavalent pneumococcal conjugate vaccine against vaccine-related serotypes 6A and 19A. Clin Vaccine Immunol. 2009; 16: 376-381. Go to original source... Go to PubMed...
    4. Park IH, Moore MR, Treanor JJ, et al. Differential effects of pneumococcal vaccines against serotypes 6A and 6C. J Infect. Dis. 2008; 198: 1818-1822. Go to original source... Go to PubMed...
    5. Siber GR, Chang I, Baker S, et al. Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies. Vaccine 2007; 25: 3816-3826. Go to original source... Go to PubMed...
    6. Jansen AG, Hak E, Veenhoven RH, Damoiseaux RA, Schilder AG, Sanders EA. Pneumococcal conjugate vaccines for preventing otitis media. Cochrane Database Syst. Rev. 2009; CD001480. Go to original source...
    7. Center KJ, Strauss A. Safety experience with heptavalent pneumococcal CRM (197)-conjugate vaccine (Prevenar ((R))) since vaccine introduction. Vaccine 2009. Go to original source...
    8. Beran J, Havlík J. Pneumokokové vakcíny, 1st Edition, Maxdorf, Praha 2009.
    9. Prymula R, Chlibek R, Splino M, et al. Safety of the 11-valent pneumococcal vaccine conjugated to non-typeable Haemophilus influenzae-derived protein D in the first 2 years of life and immunogenicity of the co-administered hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio virus, Haemophilus influenzae type b and control hepatitis A vaccines. Vaccine 2008; 26: 4563-4570. Go to original source... Go to PubMed...
    10. Prymula R, Peeters P, Chrobok V, et al. Pneumococcal capsular polysaccharides conjugated to protein D for prevention of acute otitis media caused by both Streptococcus pneumoniae and non-typable Haemophilus influenzae: a randomised double-blind efficacy study. Lancet 2006; 367: 740-748. Go to original source... Go to PubMed...
    11. SPC Synflorix.
    12. SPC Prevenar.

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