1099
PEDIATRIE341804301074588147168222260309330374
PRO736804301074591154
PRAXI911804301074692148201221
/11788043010732
Pediatr.1255804301074587137156196223250262
praxi.1537804301075077118158177193
2023;24(3):169-1741750804301074487128172186230270294337358372410449491521560596635
/24308043010731
www.pediatriepropraxi.cz46818043010765133201214264309359378418445472491535585612659709736777817836852893931
1741368026012657109161
PŘEHLEDOVÉ341207012660124182256312369444520587645
ČLÁNKY1008207012660115187259327395
Imunodysregulačné34136501061569110151192232267299334366406446477519552594626
aspekty98236501063872106138174208247
detí124536501063769103120
s1381365010631
Downovým142736501063879138179220257296350
syndrómom179236501063168110150185226280320374
LITERATÚRA34458001234978134189250318368438498567
1.3437400853648
Ni4107410834560
She4897410833270105
R,6137410833549
Filan68174108332476295133
PM.8337410833588102
Trisomy95474108333506692130188219
21–1192741083346598
incidence1309741083155285100139173212244277
and16057410833270109
outcomes1733741083377598129165224259286
in3438410831552
the408841083226095
first51684108317345582105
year,634841083316597118127
in7748410831553
Ireland84084108315367085117155194
today.1047841083225998130161171
Ir12318410831536
Med12808410835489128
J.14218410832537
2014;107(8):248-249.14718410833468100131142172204236253286304316351383419441472504537548
2.3439400853651
de4069410833872
Graaf491941083436597129148
G,6519410834457
Buckley7219410833572104134150185216
F,9499410833238
Skotko1000941083326299120150187
BG.1200941083357993
Estimation130594108333608398155187208223261299
of16169410833756
the1685941083225994
number17929410833774131170205226
of34310410833757
people41310410833874113152168203
with6291041083516689127
Down76910410834584135174
syndrome9561041083265897136157195253288
in125710410831553
Europe.13231041083326990127167202215
Eur15511041083326990
J1654104108324
Hum169210410834481139
Genet184410410834480118153175
EJHG.34311410833359104149163
2021;29(3):402-410.52111410833468101132141176210229263280292326362395415452482514526
3.34312400853651
Ďurdíková41412410834584105143158190227259292
V,72712410833544
Ďurdík79112410834684105143159190
P,100112410833640
Bánovčin106212410833568106144176208223261
P.134312410833541
Pridružené14041241083355671110132170199233271306
ochorenia173112410833770108146168202240255287
u343134108337
detí3951341083387395110
s520134108326
Downovým56013410834684135174212244278337
syndrómom.9111341083275998137158195254292350364
Pediatr.128913410833569108123155177198209
2008;3(6):338-342.151213410833469105140152187205239257269304337371394426462494507
4.34314400853651
Huggard41414410834482121160192213251
D,68614410834556
Doherty76214410834684123158179204237
DG,102014410834590104
Molloy114414410835493109124162193
EJ.13581441083325971
Immune145014410831472130168206241
Dysregulation1711144108345781051261602002372532853431541083223775113
in47415410831553
Children5441541083407893108147168202241
With8021541083587496134
Down95415410834584135174
Syndrome.114515410833363102141162199257292304
Front14671541083335289128149
Pediatr163415410833569108123155177199
[Internet].18501541083193573941281493431641083387395113125
2020;8.48916410833468101136149184198
[cit.707164108319496487100
2022-03-07]82816410833469102137157195228250287320341
Available119016410834172105120135168207223258
from:14691641083184178137149
https://www.16391641083375983123150163190210262315369380
frontiersin.org/article/10.3389/fped.2020.00073.3431741083184078116138153188209236251289302340362400426456478502517549565600626659690703738771806840863883923958998101110471081111411481161119612321268130113351347
5.34318400853650
Lee40618410833165101
YI,5201841083355164
Peng59718410833568106145
CC,7551841083407891
Chiu8591841083407893130
NC,10021841083458699
et111418410833356
al.11831841083314760
Risk12551841083365177107
factors13751841083185284108145166194
associated15821841083315884122155170202224258297
with18921841083506688127
death34319410833872103125162
in51819410831451
patients5821941083387192107141179200227
with8211941083506688125
severe9591941083256092125146180
respiratory11511941083205480119134154187208245266299
syncytial14631941083265896127160185200231246
virus17211941083324768106131
infection.186519410831452701041363432041083223775113127
J485204108324
Microbiol52420410835570102123161200216254270
Immunol80920410831573130168206244260
Infect.10852041083145271106138163176
2016;49(5):737-742.127620410833468100131144178212231264283295328362394413444474507519
6.34321400853754
Garrison42321410834579102125142170210250
MM,700214108356113128
Jeffries8542141083256283102126143179208
H,108821410834559
Christakis117321410834181104120148173207239257285
DA.148421410834688104
Risk16142141083375381113
of175321410833859
Death183821410834784117141181
for3432241083195881
Children4462241083418096112153175211251
with7182241083526993132
Down87222410834787140180
Syndrome107422410833465105146168207268304
and140022410833373113
Sepsis.153522410833470111139155182197
J1753224108325
Pediatr.180022410833671113129162185207219
2005;147(6):748-52.34323410833468104138149179210242259292310322355386422444478512524
7.34324400853644
Kusters3992441083347197119153173200
MA,61124410835495109
Bok73224410833573103
VLA,84724410833668111124
Bolz9842441083357288116
WEA,111324410835689131145
et127024410833456
al.13382441083324759
Influenza1410244108314526985122157194223256
A/H1N1167824410834068112143184215
vaccination190524410833164953432541083314684116138153191229
response5852541083205481120159197223258
is85625410831440
inadequate9092541083155385124158198235267289323
in124425410831553
down131025410833876127165
syndrome14882541083265897136157194252287
children1788254108331698499138159193231
when34326410835189124162
the5232641083215994
latest6352641083154769102129152
cut-off8052641083316991111151170189
values10122641083316480117152179
are12082641083325387
used.13132641083376398138151
Pediatr148126410833669109124156177199
Infect16972641083155372106139163
Dis18782641083456087
J.198226410832437
2012;31(12):1284-1285.34327410833468100130142177208223255285303315344374408444467498528562596608
8.34328400853652
Illouz412284108315304583121151
T,58028410833342
Biragyn6402841083355071104143175214
A,87228410834155
Frenkel-Morgenstern9452841083325286124154188204226282321342380415453480503537558597
M,155928410835568
et164528410833456
al.17192841083324760
Specific179728410833271107139154172189221
Susceptibility3432941083327096128162201223239278293309323346380
to74129410832259
COVID-1981929410833985121137183206237267
in110529410831553
Adults117629410834180117132155183
with13772941083516689127
Down152329410834584135173
Syndrome.171529410833262101140161198257292304
Neuromolecular34330410834580117139176234272288323356394409441462
Med.82130410835489129142
2021;23(4):561-571.97830410833468101133141176211229262279291326361391410444477509519
9.34331400853649
Alsubie4083141083415682120159174209
HS,6333141083447689
Rosen73831410833573100135173
D.92731410834556
The99931410833372107
evaluation11223141083346699114152184206221259298
and143531410833270109
management156031410835790128160199234292327365386
of196231410833757
respiratory3433241083215583122138159193215252274308
disease6723241083395480116148175211
in90332410831553
children9773241083327085101140162196235
with12333241083516689128
Down138232410834584136175
syndrome15783241083265998138159197256292
(DS).18903241083196598118129
Paediatr34333410833567102141157189210232
Respir5903341083357097136152173
Rev.77833410833671103113
2018;26:49-54.90633410833468100131143178212224259292315349385397
10.3433440085367086
Ram44934410833669127
G,59734410834458
Chinen6763441083407994132168207
J.90334410832538
Infections9613441083155473108141166181220259285
and126734410833271110
immunodeficiency139834410831573132170209247288323341358391406441480512546
in196534410831553
Down34335410834584135174
syndrome.5323541083265997136158195253288300
Clin8483541083405570108
Exp97135410833365105
Immunol.109135410831572130168206244260273
2011;164(1):9-16.137935410833569100128136166198234254285300312347370401432446
11.3433640085356476
Uhliarová4313641083438095109140160196227259
B,70236410833547
Švec7613641083326295126
M.89936410835467
Dieťa9783641083456093115147
s1137364108325
Downovým117436410834582132170207238271328
syndrómom15143641083265795133153190246284340
v1866364108331
ambulancii1909364108332883433741083397792124162195210225
ORL58337410834783116
lekára.7143741083155080114135168181
Pediatr.91037410833569108124156177199209
2017;12(2):79-82.113437410833569101130140170200217251269281314347371407441453
12.3433840085356782
Eijsvoogel436384108332466186119155193232266281
NB,7293841083447991
Verstegen8323841083356788114137170208242280
RHJ,112438410833479103114
van125138410833163100
Well136338410835789104119
GTJ,14943841083437697108
et161438410833455
al.16813841083324659
Increased17523841083145183103136167193227266
rate3433941083215577112
of47639410833757
respiratory5543941083215684123140161195217255277312
symptoms88739410832760120160182220280307
in121539410831553
children12893941083327186102142164198237
with15473941083526891130
Down169839410834685138177
syndrome:1896394108327601003434041083396199159195208
a572404108332
2-year6264041083345688124156178
web-based82640410835186127151192226253289330
parent-reported11774041083407495130170192212235270310350372398433473
prospective167140410834062100128168205238263279312348
study.3434141083264987126158168
Eur5274141083326990
J632414108324
Pediatr.67241410833568108123155177198208
2022;181(12):4079-4089.89641410833468101136148178209241256288318336348382418450484507544580615650661
13.3434240085366883
Weijerman44142410835791106121156177235268306
ME,76242410835488101
Brand8784241083365790128167
PLP,106042410833566102107
van118242410833265103
Furth13004241083326990115153
MA,146842410835596111
et159442410833456
al.16654241083324861
Recurrent174142410833570103141162184218256277
wheeze34343410835189124159189223
in58043410831553
children647434108331698499138159193231
with8924341083516689127
Down103343410834584135174
syndrome:12214341083265897136157195253288300
is153543410831541
it159043410831537
asthma?16414341083325882120178210235
Acta18904341083417296129
Paediatr.34344410833567102141157189210232242
2011;100(11):e194-197.60044410833569100128136166198234254285313327339374403434469492523553586593
14.3434540085366883
Perluigi4384541083356888104141155194208
M,65945410835367
Di73845410834560
Domenico81045410834583140175212227258295
F,111745410833237
Buttterfield11674541083357294118142175196215232266281319
DA.14994541083458498
Unraveling160945410834481101134165198214228265304
the19254541083215993
complexity34346410833168126166181216248263286320
of67646410833757
neurodegeneration74646410833873111132169209243283318356391412445467482520559
in131846410831553
brains13854641083386093108146172
of157146410833756
subjects164146410832663102118153185209237
with18924641083506688127
Down34347410834584135174
syndrome:5324741083275998137158195254289301
Insights849474108315537994133171192220
from10854741083184077136
proteomics.12374741083386097119153191250265297324338
PROTEOMICS159147410833570118150184232287302343377
–1984474108335
Clin3434841083405570108
Appl.46648410834181120136149
2014;8(1-2):73-85.63048410833468100131143178197229248279297309342376398434468480
15.3434940085366883
Huggard44549410834482121160192213251
D,71649410834556
Kelly7914941083356985100132
L,94249410833145
Ryan100649410833668101139
E,116549410833245
et123049410833456
al.13054941083324760
Increased13844941083155385107141173199234274
systemic16774941083265986109142200216247
inflammation1944494108314523435041083173569129189223246262302342
in70850410831554
children7855041083327288104145167203242
with10505041083526993132
Down120550410834787140181
syndrome.140950410832660101142164203264300313
Cytokine.17455041083417096135167185224261274
2020;127:154938.34351410833468101135148178208241251281311346379412446460
16.3435240085366985
Pako4455241083356797135
J,59752410832437
Bikov6515241083365181118150
A,81952410834155
Karlocai8925241083356889105143176209224
K,113452410833549
et120152410833456
al.12755241083324760
Plasma13535241083355082108166198
VEGF156952410833670114147
levels17345241083154982116132158
and190952410833270109
their3435341083226095110131
relation4915341083215570102124139177216
to72453410832158
right7995341083213675113135
ventricular95153410833166104125147162194232247280301
function12695341083185795127151166204243
in152853410831553
pulmonary15985341083387792150188226259280314
hypertension.1929534108337683435441083397495120154192218233271310323
Clin6815441083405570108
Exp80454410833365105
Hypertens.92454410834476116152173198231269296309
2015;37(4):340-344.124954410833468100130140175208224257274286321357393417449484521534
17.2138740085366876
Chotsampancharoen22357410834078116138166199257296329367399437470491528564602
T,28577410833342
Chavananon29197410834078110142175213245283321360
S,32997410833346
Sripornsawan3365741083325369108147169207234267318350388
P,37747410833540
et21388410833456
al.2213841083314760
Transient2291841083335083121147162197235256
abnormal25668410833171109147169227260275
myelopoiesis28598410835888123138177216255270305332347373
in32508410831553
Down33218410834584135174
syndrome:3513841083265997137158195253288301
Experience21389410833365104140161176211249281314
of24659410833756
long2534941083155391130
term2677941083215576134
follow282494108318567286124175
up30129410833776
from3101941083184077135
a324994108332
single3294941083264078117132167
tertiary3474941083215576100115147168202
center3689941083316510321381041083225577
in223010410831552
Thailand.229810410833272104119134166204244257
Pediatr257010410833569108123155177198
Hematol278410410834479137169191228244
Oncol.304310410834786118155171184
2023;40(2):108-116.324210410833468101136147182218238271289301331362398421451479510524
18.21381140085366985
Schoch223811410833265103141174212
J,246411410832436
Rohrer251511410833573112133167188
TR,27181141083326983
Kaestner281611410833468103130153191226248
M,307811410835468
et316011410833457
al.32311141083324760
Quantitative,330511410834786118156177193215248270285318352364
Phenotypical,36831141083357310821381241083377597130170185217249265277
and242712410833270108
Functional254812410833268106138161177214252284299
Characterization286012410834077109130163195218252273288317350372387424462
of333512410833756
Cellular34041241083407388103140155187208
Immunity36251241083157212916721381341083375275108
in225913410831452
Children23241341083407792107146167201239
and257613410833169108
Adolescents269713410834079117132167194226259297318346
With30561341083577395133
Down320213410834583134173
Syndrome.338713410833362101140161198256291303
J3702134108325
Infect37391341083155321381441083185385110
Dis.22631441083456187100
2017;215(10):1619-1628.237914410833468100129139174205235253285316335347376408438468492522554587621634
19.21381540085366881
Marcovecchio223215410835486107138174206240272303340355393
GE,26371541083447790
Bortolomai27391541083367495119156171209267299314
I,306615410831427
Ferrua31051541083326687109146178
F,329615410833238
et334715410833355
al.34151541083324759
Thymic348715410833271102160175206
Epithelium3706154108332718621381641083215994109123160218
Abnormalities236816410834180117155176234266281296318333367393
in277416410831452
DiGeorge283816410834560104139177199236271
and312116410833269108
Down324116410834583134172
Syndrome342516410833262100138159196253288
Patients37251641083356721381741083223772111132160
Contribute231917410834077116138159175215253276310
to264917410832259
Dysregulation272917410834679106127161201239255287309325363402
in315117410831553
T3225174108332
Cell32781741083407490105
Development.340417410834581114148164202242301336374396410
Front21381841083325289128149
Immunol.230318410831472130168206244260273
2019;10:447.259118410833468100130143173205218252289321327
20.21381940085377490
Buc225019410833675108
M.238019410835670
Heterogenita247219410834581104139161200240276316332355389
lymfocytov288219410831548109128167201236261299332
ako323619410833264102
ústredných33601941083386589111147187227258291330
operačných37121941083387821382041083355791125164196229268
jednotiek24282041083155192132172195211247278
imunitného272820410831575114153169193232269308348
systému.30982041083276189113148208247261
Vnitř33812041083367591114137
Lékařství.35392041083326899134156185209245261275
2019;65(2):86-97.213821410833468100130143179213230264282294329364388423455462
21.21382240085367082
Rueda223822410833573108148180
N,243622410834457
Flórez25112241083334785107141171
J,270022410832436
Martínez-Cué275422410835487108133148186221250272315351386
C.315822410834053
Apoptosis322922410834181120159181218245260286
in353322410831452
Down’s360322410834684135174186211
syndrome:21382341083265997137158195253288301
lessons24522341083155077103142180206
from26722341083184078136
studies28222341083264987126141176203
of303823410833757
human310823410833875133166204
and332523410833270109
mouse344823410835795133160195
models.3656234108358961352138244108334507689
Apoptosis224224410834181120159181218245260286
Int25432441083155374
J2633244108324
Program26722441083355693133154187245
Cell29322441083407489105
Death.305224410834581112134172186
2013;18(2):121-134.325324410833468100130141171202221255273285315345376395426456491504
22.21382540085367288
Huggard224325410834482121160192213251
D,251125410834656
McGrane258425410835587132154187225260
F,286025410833339
Lagan291525410833265104137175
N,310625410834558
et318125410833456
al.32542541083324760
Altered33312541083415679112134168207
endotoxin355525410833472111149171208238213826410831553
responsiveness22042641083215582121159198224239272306344379406432
in265026410831552
healthy271626410833873104120142180211
children2941264108331698499138159193231
with31862641083506688127
Down332626410834684135174
syndrome.35132641083275998137158195254289301
BMC213827410833590131
Immunol.228427410831573131168206245261273
2018;19(1):31.257327410833468100131143173203223254269281316347356
23.21382840085367287
Chung224628410834078115153192
H,245828410834457
Green25352841083436599134173
PHR,272728410833579115129
Wang287628410835788126165
TC,30612841083337285
et316528410833457
al.32412841083324760
Interferon-Driven33212841083155374108129151185206244282305352373389422456494
Immune213829410831573130168206241
Dysregulation239329410834578105126160199237252285306322360398
in280529410831452
Down287129410834584135173
Syndrome:305829410833362101140161199257292304
A3376294108341
Review343129410833570102118153204
of364929410833756
the37192941083216095
Evidence.21383041083336480119154192224258270
J2423304108324
Inflamm2463304108315537087119177235
Res.27133041083367097111
2021;14:5187-5200.283930410833468101133141171202214250281312345363397430464501513
24.21383140085356984
Khocht223431410833472109141178198
A,244431410834054
Russell25103141083347196122156171185
B,270731410833446
Cannon276531410833971108145182219
JG,29963141083246780
et308831410833354
al.31543141083314658
Oxidative32243141083467791129160181196227260
burst34963141083387595122144
intensity365231410831451711041412138324108326406396
of224632410833756
peripheral23153241083387494110148186221242275290
phagocytic261732410833977109147185217250275290321
cells2951324108331647994120
and308332410833270108
periodontitis32043241083387394109147186224262283298320335361
in357832410831452
Down364232410834583134172
syndrome.21383341083265997137158195253288300
J2454334108324
Periodontal24933341083356990106144183221260281314330
Res.28383341083357097111
2014;49(1):29-35.296433410833468100131143178211230262276288323357381413446458
25.21383440085367287
Bloemers22443441083355189125183218239266
BLP,252934410833568103108
van265634410833164102
Bleek27773441083365186122152
GM,294834410834398112
Kimpen307934410833551109148183221
JLL,33193441083255789102
et344034410833456
al.35153441083324760
Distinct35943441083466187110126164196220
abnormalities213835410833271109148169228260275290313328363390
in254135410831452
the26063541083226095
innate27143541083155391123145178
immune290535410831573131168206241
system31593541083265986109143201
of337335410833756
children34423541083326985100139160194232
with36873541083516689127
Down213836410834584135174
syndrome.23273641083265897136157195253288300
J2642364108324
Pediatr.268136410833569108124156177199209
2010;156(5):804-9,290536410833468100132145175205239258291310322357392428451486496
809.e1-809.e5.341636410833570105116151181199235270306317351386398
26.21383740085367187
Cossarizza223837410834077103130163184200229260293
A,254537410834055
Ortolani26133741083466893130146178216231
C,285737410834053
Forti29233741083326991115131
E,306737410833245
et312537410833456
al.31943741083324760
Age-related326737410834180114137159193209241263297336
expansion36163741083346510513817621383841083264179117
of227538410833756
functionally23503841083195795127152167205243276291306338
inefficient27073841083155287106124141174189223262283
cells3009384108331658196122
with31503841083506689127
markers329638410835790111141175197224
of353938410833757
natural36153841083377091129150183199
killer2138394108329455973107128
activity22773941083326386100132147168201
in249039410831451
Down’s255339410834482131169180204
syndrome.27693941083265795133153189246280291
Blood.30723941083355087124162175
1991;77(6):1263-1270.32593941083336296127135167200216248265277305334367399420450479511543555
27.21384040085367180
Satgé22314041083326587125159
D,240340410834657
Seidel24724041083336883122156172
MG.265740410835499113
The278340410833271106
Pattern29024041083356789113147168206
of312140410833757
Malignancies319140410835487102117155193226264296311345372
in357640410831552
Down364140410834684135174
Syndrome213841410833262101140161199257292
and244941410833270109
Its25774141083153765
Potential26614141083357294128166187203235250
Context293041410834077115137171202227
With31764141083577396134
the33294141083226095
Immune344341410831573131168206241
System.37044141083326289213842410832255113127
Front22804241083325289128149
Immunol.244442410831573131169207245261274
2018;9:3058.273342410833468100131143179192227261296330343
28.21384340085357186
Li223743410833146
YY,22954341083357280
Alexandrov23874341083415690120152189228248284316
PN,27154341083347890
Pogue281743410833571110146180
AI,30094341083415668
et308943410833355
al.31564341083314659
miRNA-155322743410835671106151191212242271303
upregulation3542434108337759612916820421925121384441083223775113
and226544410833169108
complement238744410833168126165181216274309347369
factor27694441083185284108145166
H2949444108344
deficits30064441083387390107139155177205
in322444410831552
Down’s329044410834584135173185210
syndrome.35144441083265897136157194253288300
Neuroreport.213845410834580117139176197232271310331356369
2012;23(3):168-173.252245410833569100130143178213231264281293323354390412443473507519
29.21384640085367386
Veteleanu22454641083366991125141176208247285
A,255046410834156
Pape262646410833668107143
S,279046410833245
Davies285646410834678110126161188
K,306546410833549
et313546410833457
al.32124641083324861
Complement329446410834077136175191226285320358380
dysregulation3695464108338709821384741083215594132147179201216254293
and244647410833270109
Alzheimer’s25704741083415685124159174232267288302327
disease29124741083385480115147173208
in313547410831553
Down320347410834584135173
syndrome.33914741083265998137158195253289301
Alzheimer`s3707474108341568521384841083397591151188210230256
Dement241648410834784144181221243
J2682484108325
Alzheimer`s27304841083425889129166182242278301320346
Assoc.30994841083427199139173187
2022.330948410833571105142155
https://doi.34874841083396187128156170198219257297313327
org/10.1002/alz.12799.21384941083375997123156188200231262299331358388404433447478507540574609620
30.21385040085367287
Fitzgerald22395041083324770100138173195228243282
KA,25345041083357993
Kagan264050410833569108140178
JC.28315041083246578
Toll-like2922504108333678398120136151181215
Receptors315050410833671103137176198235257284
and344750410833270109
the35695041083226095
Control3677504108340771152138514108322438096
of225051410833756
Immunity.232151410831573131168206222244278288
Cell.26245141083407489104117
2020;180(6):1044-1066.275751410833468101135148178209244264297315327357388424461484515547582618631
31.21385240085366981
Huggard223252410834481120159191212250
D,249452410834556
Koay256352410833472104135
WJ,27105241083587991
Kelly2813524108335698599131
L,295752410833144
et301452410833456
al.30825241083324760
Altered31555241083405678111132166205
Toll-Like3373524108332668297119152167197230
Receptor36165241083357010213617521385341083215879
Signaling22295341083334785123155170184221260
in250153410831552
Children25665341083397791106144165199236
with28155341083506587125
Down295253410834583134172
Syndrome.313653410833261100138159196253288300
Mediators344853410835489127142174195231253279
Inflamm.37405341083155221385441083173466124182195
2019;2019:4068734.234854410833469100131143178212244274287322358393429462496532544
32.3934740085377492
Huggard40517410834586127169204227268
D,43447410834659
Molloy44277410835697115132173207
EJ.4658741083346377
Question47607410834889126156181199239280
1:50657410833545
Palivizumab5135741083367088105140158189230291326368
for5528741083185983
all3934841083335170
children4041841083327492111154178216258
with4336841083527197139
Down45128410834689145187
syndrome?47368410832763106149174215278317345
Arch51188410834267102144
Dis5299841083466595
Child.54318410834182101119162179
2019;104(1):94-97.39349410833470103134149180213251271305320334370407432468502510
33.39341040085367289
Gutfraind404110410834483107130153188204243284
A,434210410834157
Galvani44171041083437794128162202218
AP,46531041083417884
Meyers475410410835591124160183211
LA.49831041083317692
Efficacy5092104108333537694127161195230
and533910410833272112
optimization546910410833778101118393411410835773104138161178217256
of420611410833757
palivizumab42791141083387289105139156186225284318358
injection46521141083155470106140165182221260
regimens49281141083215696113171208247274
against521811410833172105121160188212
respiratory5446114108320558312314039341241083215578117140175
syncytial412612410832660100134169195212245262
virus44051241083324971111139
infection.45611241083145474110144170186226265280
JAMA485812410832466123166
Pediatr.504112410833570111128161184207219
2015;169(4):527712410833470103134146178210246266301319333
341-348.393413410833471103123157193231246
34.39341440085367388
Kimura403614410833551109147168201
T,425014410833341
Takeuchi43051441083326090124162194232247
M,456614410835468
Kawakami464714410833568119152182216273288
K.494914410833550
Utilization5012144108344668297112141174196211249288
and531314410833270109
efficacy5435144108334527088120153393415410833165
of401415410833756
palivizumab40851541083397287102135150180218276308347
for44471541083195678
children4540154108331698499138159193231
with47861541083516789127
Down492815410834684135174
syndrome.51171541083265897136157195253288300
Pediatr543215410833569108123155393416410832243
Int39921641083155375
Off40821641083476887
J4184164108324
Jpn422416410832463101
Pediatr434116410833568108123155177198
Soc.455516410833270103116
2020;62(6):677-682.468716410833468101135148184217234268286298333366400419456492525538
35.39341740085367084
Huggard403117410834481119157189210247
D,429117410834455
Molloy435817410835492107122159190
EJ.45601741083335971
Question464317410834784118145167182220257
1:491317410833442
Do496717410834583
children5062174108331688398136157190228
with53021741083506587125
Down543917410834583133171
syndrome39341841083265998137158195254289
benefit424318410833975113148166183205
from44691841083184078136
extra46251841083346691112145
vaccinations?47911841083316497127143181213235250288327353378
Arch51891841083416394132
Dis53421841083456187
Child.54491841083407893108147161
2018;103(11):1085-1087.393419410833468100131143173205238256288315330342371403438472494525557592625631
36.39342040085367288
Espinosa40402041083336099115153191218251
JM.43092041083247993
Down442020410834584135174
Syndrome461220410833262101140161198257292
and492220410833270109
COVID-19:504920410834085121137183207238268281
A5348204108341
Perfect54072041083356990112146179203
Storm?39342141083325491112171195
Cell41442141083407490105
Rep426421410833671110
Med.438921410835590129142
2020;1(2):100019.454721410833468101135148178193227245257286318354390422452463
37.39342240085377281
Hüls40372241083458499126
A,418422410834257
Feany426222410833368101140171
PT,44542241083367180
Zisman45552241083395481140173212
SI,47892241083334861
et487122410833558
al.49502241083324862
COVID-19503322410834187124141187212244275
Vaccination532922410833668101133148187220243259393423410833776
of402623410833756
Individuals40982341083155392107140156194232264280306
with44202341083506688126
Down456223410834684135174
Syndrome475223410833362101140161199257292
–5060234108335
Data51112341083457899132
from52592341083184178136
the54112341083226095
Trisomy55222341083335065393424410832766125157
21411224410833567
Research420024410833672100136169190222261
Society448224410833373106122158181215
Survey47182441083337293129164197
on493624410833877
Safety,50342441083346787122145180190
Efficacy,5245244108333527088121155188222232
and549924410833271111
Factors39342541083326294118155177204
Associated41542541083416895133166181213235269308
with44782541083506688127
the46202541083226095
Decision473125410834581113128154169207246
to499225410832259
Be506725410833570
Vaccinated.51532541083366799130145183215237271310323
Vaccines.5492254108336679939342641083314684119146160
2022;10(4):530.410926410833468101136148178210229262280292327360394407
38.39342740085367288
Cao403827410834073111
C,416427410834053
Wang423327410835789127166
J,441427410832436
Li446627410833147
Y,452827410833544
et458727410833456
al.46592741083324760
Efficacy4735274108332506886118151183216
and496727410833270109
safety50912741083266078113135169
of527527410833857
OM-855348274108347102124160194
in555827410831452
paediatric393428410833972107146161193215236252284
recurrent42362841083215588126147168202241262
respiratory45162841083215582121137158191212249271305
tract48392841083224376108133
infections49902841083155271106138163178216254281
which528928410835189104136174
could548128410833269107393429410831554
have400329410833769101135
a4153294108332
possible419929410833978105131146185201236
protective44502941083386097119153185210225257292
effect47562941083345473107140164
on493529410833776
COVID-19502529410834086121138184207238268
pandemic:530829410833972110149184242257289302
A3934304108341
meta-analysis.399030410835893115148170202241273288320347362388402
Int44073041083155374
J4496304108325
Clin45363041083405570108
Pract.46593041083355689121145159
2021;75(5):e13981.483330410833468101132141174206224258276288322352382415450482491
39.39343140085367184
Marseglia403231410835487108135170209225239271
GL,43163141083447689
Benazzo441831410833671109141170202239
M,467031410835467
Biasci47503141083365183109141156
P,491931410833540
et497231410833356
al.50413141083314759
OM-855113314108347102125161195
in532031410831553
the53863141083215994
prevention54933141083396094393432410833266104126141179217
of416532410833756
respiratory42353241083215582120136157190212249270304
infections:45533241083155371106139163178216254281293
State-of-the-art48603241083325386108142165204224244267305340363395416441
and531532410833169109
future54373241083185780118139173
perspectives39343341083387393120157192224247262293327353
in429933410831451
clinical4362334108331466097111142174189
practice.45633341083385991122146160191224236
J4811334108323
Biol48463341083355087102
Regul496033410833569107144159
Homeost513133410834380137172209235258
Agents.540133410834077111148169196209
2021;35(3):847-863.393434410833468101133141176209226260277289324360392411447482516528
40.39343540085367489
Luan404335410833168101139
H,420235410834457
Zhang427935410833876108146185
Q,448435410834761
Wang456535410835889127166
L,475135410833245
et481735410833456
al.48933541083324760
OM85-BV4974354108347102137171193230266
Induced52603541083155392129162195235
the55153541083226095
Productions39343641083355693133170202226242280318345
of429236410833757
IL-1β,4362364108315476293128139
IL-6,4515364108315476299112
and464036410833270109
TNF-α476336410833279112133172
via49493641083324879
TLR4-504236410833366102137160
and521636410833169108
TLR2-Mediated53383641083336610213715821424939343741083385385106140179
ERK1/2/NF-κB412637410833267103134156191217262295316349385
Pathway45243741083356788126176209240
in477637410831552
RAW264.7484137410833578133168201238250284
Cells.51383741083397388103129142
J5293374108324
Interferon53303741083155274107128149184205242280
Cytokine39343841083406893129160176214249
Res.41993841083357097110
2014;34(7):526-536.432538410833468100131143178213233267287299334367401424458491526539
41.39343940085366981
Chia40333941083407893125
E,417639410833245
Clark42393941083405587109139
A,439639410834155
Flynn44693941083324779118156
B,464239410833648
et470839410833457
al.47823941083324861
P549486039410833669104137
Should501539410833370109147162201
children5234394108331698499138159193232
with54833941083516789127
down393440410833979132172
syndrome412740410832761101142164203263300
receive44484041083215791126142176211
prophylactic468140410834062101142182214231265298323339373
antibiotics50754041083337395111152168208231247280309
to540640410832260
prevent54884041083396298393441410833266105127
recurrent40814141083215588126148170204242264
respiratory43664141083215582121137158192214251273307
infections?46934141083155372107140165180218257284309
Arch50224141083416394132
Dis51754141083466188
Child.52834141083407994109149162
2019;546541410833569101132145
104(Suppl393442410833466102121153190230269285
3):A373-A373.42344241083355264106142174208230271307339373385
42.39344340085367086
Huggard403943410834482121160192213251
D,430943410834556
Kelly43844341083356984100131
L,453443410833145
Worrall459743410835894116138171186201
A,481743410834155
et489043410833457
al.49654341083324760
Melatonin504443410835489105137159196234249287
as535043410833158
an542743410833169
immunomodulator551543410831572393444410835795133171230268307345360393414451473
in442744410831452
children44994441083316985100139160194232
with47514441083506688127
Down489844410834584135173
syndrome.50914441083265998137158195253288301
Pediatr541144410833669109124156177199
Res.39344541083357097111
2022;91(7):1812-1820.406045410833468101136148184216231265285297327358390420440471502535569582
43.39344640085357085
Saghazadeh403146410833264103140171200233271306343
A,438646410834155
Mahmoudi445346410835485123180217255293307
M,477346410835467
Dehghani485246410834579117155192224261276
Ashkezari514046410834068105134168197229250265
A,541746410834155
et548446410833355
al.55514641083324759
Systematic39344741083326288111145202234256271302
review42494741083205486101136186
and444847410833269108
meta-analysis456947410835791113146168200237269285316343357383
shows496547410832663101152178
a5156474108331
specific520047410832665100132147164181213
micronutrient54264741083577110312416139344841083387598119135169207229
profile41774841083396098115132147182
in437348410831553
people444048410833974113152168203
with46574841083516689127
Down479848410834584135174
Syndrome:498648410833262101140161198256292304
Lower530448410833169120154176
blood54944841083385492393449410833777
calcium,40244941083316479111127164222235
selenium42724941083266176111149164202260
and454549410833270109
zinc,46674941083284482114127
higher48074941083375291129164185
red50064941083205494
blood51134941083395493131171
cell5297494108331658196
copper540649410833168107147183204
and393450410833270109
zinc,40575041083284381114127
and419750410833270109
higher43205041083375391129164186
salivary4519504108326607590123155177211
calcium47435041083326480112127164222
and497950410833270109
sodium.510250410832664104119156214227
PloS53435041083355088120
One.547750410834786121133
2017;12(4):e0175437.393451410833468100129139169199217250267279313349381410443478511543549
44.39345240085367490
Stagi40395241083325486125141
S,419552410833245
Lapi425652410833164104119
E,439152410833245
Romano445252410833573132164202240
S,470852410833245
et476852410833456
al.48405241083324760
Determinants491552410834681103137158217232270302340362389
of532052410833756
Vitamin53925241083355274107165180218
D3934534108345
Levels39925341083326698132148174
in417953410831452
Children42445341083407893108147168202240
and449753410833270109
Adolescents461953410834179117133168195227261299320348
with49805341083516689127
Down512053410834584135173
Syndrome.530653410833362101140161199257292304
Int39345441083155374
J4024544108324
Endocrinol.406354410833370110148180202217255293309322
2015;2015:896758.440154410833468100130140175209241271282317351387420452487500
www.pediatriepropraxi.cz51373870337206420634681842984114412081341143115211586172618851977212822872379251426462711276828923017
Pediatrie51371180289138258400466592678772837960
pro151971180289140233368
praxi193271180289140233356482549