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Ambulance3401740013367158220281306359419468521
Gynekologie8851740013371121183238289348374434496521576
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Praha2891174001335892145206258
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není6892250012156106161183
novým8982250012156111157208292
fenoménem,1215225001213080135189273323378428512532
nicméně1772225001215779123206256311361
epidemie21582250012151108130186236320342392
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v29102250012149
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s8362390012139
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akcelerací1089239001214893134181203252282329372393
v14982390012148
době15622390012156109164213
covidu1791239001214597142164218271
19,2078239001215195110
je2204239001212573
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nejen27542390012155104126174228
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faktory,3511239001213077121155207238286301
ale340253001214870119
i4832530012124
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stylem907253001214072120143191274
a12052530012149
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vede1034267001214894149196
k12432670012147
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rezistenci,1722267001213279120141177208255308350370388
kdy2124267001214699143
buňky22812670012156109161205253
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reagovat3460267001213380125179231275321351
na3402810012155101
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což1212281001214596136
vede1366281001214895151199
k15822810012147
jeho1647281001212473126180
nadprodukci,18442810012156102156211242295350402447489510528
k23902810012147
hyperinzulinemii.2455281001215599154203234256309350403425446499547629650671690
Zvýšená3163281001215598147185233287333
hladina3513281001215677123178199252298
inzulinu340295001212377118171192213266319
stimuluje67729500121397192173226248300322370
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k14602950012147
nadměrné15252950012155101156237286316370419
produkci1962295001215687140195248293334355
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a28012950012148
androgeny28672950012148102156187239294342396439
mohou33242950012184137191244297
dále36392950012156102124172
zhoršovat340309001214295147178215268312358388
inzulinovou741309001212376116169190210263315359410463
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a16013090012148
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hladinu2023309001215576122176196249301
inzulinu2337309001212376116168189210262314
v26643090012148
krvi.2725309001214778127148166
Tak2905309001214988132
vzniká3050309001214890143163207254
bludný3317309001215678130184236279
kruh,3610309001214678130183201
kdy3403230012147102148
hyperinzulinemie5133230012156100157207238260314356410432453507556639661710
a12483230012148
hyperandrogenismus13213230012156100157207238286340395426480535584639660698780833871
se2217323001214089
navzájem23313230012156103148192240263312394
posilují.27503230012158113150172194247269291310
Mezi30853230012181131173195
typické3305323001213382138160204249297
další36263230012157104126163185
zdravotní340337001214396127173217268299352372
komplikace726337001214798179233255276320367409456
patří11953370012157103133163185
diabetes,1393337001215677122177225257303341359
hypertenze,1766337001215598153202233266313366407454472
hyperlipidemie2252337001215598153202232254275329350404452533554602
a28673370012148
metabolický29293370012183131162208263316338359401445493
syndrom.3435337001214086139194224276357376
U3403510012165
adolescentních4223510012148105160183234273318367422454509532576631
dívek1071351001215679127176223
může13123510012183138180230
obezita15603510012154111162205228261310
způsobit1888351001214299154193248305328361
i22673510012123
časnější2308351001214593132187237260299322
nástup26483510012155103142175230286
puberty29523510012157112168219252288337
a33073510012148
menarche.33733510012183133189237269313368418438
Důsledkem3403650012166120158180229286331379461
hyperandrogenismu8183650012155100156206238286340395427480536585640662700781835
bývá16703650012156102152200
nepravidelné18873650012154104160192239285308364413436490539
krvácení2443365001214780130178221269324346
nebo28063650012155104160215
vynechání3038365001214897152202246300347401424
menses,34793650012182132186224273312332
dále3403790012156103126175
pak5323790012157104150
syndrom699379001214087142198230283366
polycystických10823790012156111134181224273311344367411456506549603
ovarií17023790012154101148180203225
i19443790012124
vyšší1985379001214797136174196
výskyt2198379001214898136182231267
dysmenorey24823790012156103141223273327382414463509
a30083790012147
premenstruálního3072379001215789138220270325363396428482529552606629685739
syndromu.340393001214088144201233288371426447
Klíčová340409001246291119164222275328
slova:695409001244473131184237263
obezita,9854100012155113164208232265315336
menstruační13494100012184135192231265298354402447503526
cyklus,1904410001214595143168223263284
hyperandrogenismus,22174100012156101160211244293349406439494551602658682721804860899920
hypermenorea,31664100012156102160212245329380436492525575624645
polycystická3404240012157113137184228278317351374419465514
ovaria,8764240012155102150183206254275
osa1172424001215594143
hypotalamus13374240012155101158214247296319367451505544
–19034240012150
hypofýza19744240012155101158214243294339389
–23844240012150
ovarium.24564240012154102150183206261344365
The3404510012455114167
influence527451001242786121150209262321367419
of966451001245893
obesity10794510012458118171216243280335
on14344510012458117
the1571451001243796150
onset17414510012458117160213251
of2012451001245893
puberty21254510012460119179232271310365
and25104510012453111171
the2702451001243696149
menstrual28714510012486140199243280319378431459
cycle33504510012445100144172226
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is656469001212459
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a8774690012148
new9384690012154102171
phenomenon,11224690012156109156209260340388440492545563
however16974690012155107176223267313343
the2053469001213284132
obesity21974690012155108156193213243290
epidemic25004690012149103124177224304324366
in2879469001212375
the2967469001213284132
last3111469001212468104135
few3259469001212976146
decades34184690012155102145190244291327
–37624690012149
with340483001217495126180
further539483001213083114148201250280
acceleration839483001214891133180202250281328358379432486
in1345483001212376
the1441483001213387135
time1596483001213354135184
of1800483001215582
Covid19024830012158109154176231
192153483001215194
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is2337483001212360
caused2417483001214491144181229284
not27214830012156109140
only28814830012155108130175
by30764830012157101
genetic31974830012156104158207238259302
factors,3519483001212976119152204235273292
but3404970012157110140
also494497001214869105158
by6654970012157101
lifestyle77949700121244571119156188235257305
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environment12664970012149103147168198250303384432485515
(nutrition,1795497001212878130161191212243263316369388
physical21964970012157110153190211253299320
activity,2530497001214890123144189211242289303
perinatal28464970012157106136157210256286332353
programming).3213497001215687139193223269350430451504558582598
Obesity3405110012169124174211232263311
usually671511001215592144190212233278
leads969511001212372118173209
to1198511001213385
insulin1303511001212377113166187208261
resistance,1584511001213381118139176208254308351398416
when20195110012174128176230
cells2268511001214592114135172
cannot2460511001214591145198251282
respond2761511001213381118173227280335
sufficiently3116511001213992119150174217238286340370391436
to3572511001213385
the3677511001213386135
action340525001214891124145197251
of605525001215481
insulin,700525001212376113165186207260279
which9925250012174127148191243
leads1249525001212472118172209
to1472525001213384
its157052500121235493
overproduction,16765250012155100147178233263316371423466499520573626645
to2334525001213385
hyperinsulinemia.2433525001215599154203234255308345397418439492540621642688707
Increased3154525001212377119150197243280328383
insulin3551525001212376113165186207260
levels340539001212472118165187223
stimulate58353900121397192173226247293324371
the973539001213386135
ovaries11275390012155100146177198247284
to1430539001213385
overproduce15345390012155101148178234265317373425468515
androgens,20685390012149102156187239294342396433452
and25395390012148102156
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can3166539001214591145
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insulin498553001212376113165187208261
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blood1705553001215779132186241
insulin1962553001212477114166187208262
levels.2240553001212371117164186223242
This24985530012150104125162
creates2676553001214575123169199247284
a29765530012148
vicious3040553001214870113134187240277
circle333355300121456696138159208
where35575530012173127175206254
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reinforce2061567001213382104159186240272315363
each2449567001215198141195
other.2669567001215687142191223237
Typical2931567001215191147170213261283
other3239567001215587141191222
medical34865670012185134191212256303325
complications340581001214596178232254275318364395416468522559
include913581001212376119140193247295
diabetes,1222581001215778123178227258305343362
hypertension,1598581001215599154203234268315368405426479532551
hyperlipidemia,2163581001215599154203234256276331353407455537558603622
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metabolic29695810012183132163210264318340361404
syndrome.3386581001214086140195225277359407425
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adolescent4395950012149105160184235274319368424456
girls,915595001215679112136174196
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an20715950012148103
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onset24755950012155111149200233
of2728595001215584
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and31915950012148104160
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consequence5296090012146101158198250308364416473519569
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bleeding2575609001215883135187246269326384
or2988609001215690
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menses,34636090012185137194233285326348
as340623001214887
well4496230012174123147170
as641623001214887
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ovary11906230012155102151183234
syndrome1445623001214088144201233288372422
and18896230012148103160
a20716230012148
higher2141623001215578134189240273
incidence2435623001212479124147203254309355404
of2860623001215584
dysmenorrhoea29666230012156104143226277333388421454509564615663
and36516230012148104160
premenstrual340637001215790140223274330368402435490538562
syndrome.923637001213987144200233287371422442
Key3406500012460110160
words:5166500012474129167225268292
obesity,8246510012154109159197219251299314
menstrual11546510012182131185223255286340387409
cycle,1579651001214492135157206224
hyperandrogenism,1820651001215498154204235282336391422475530579633655692773793
hypermenorrhoea,2629651001215499155204236317366420474505537591644694740760
polycystic34066510012155110133179221269307340362405
ovary,3406650012155102151183233249
hypothalamus6116650012155101158214247302350374422505560599
–12316650012150
pituitary1302665001215780114168192225274306356
–16806650012150
ovary17516650012155102150183233
axis.2005665001214996120158180
Zkratky:3407030014365115152207243294351373
BMI4807200010949121144
–6437200010945
body7077200010951102154197
mass9237200010975119154190
index1132720001092171122168211
WHO4807340010976135198
–6987340010945
World7627340010976123153175227
Health10087340010958104148169199249
Organization1276734001096293143187237258297342372393443493
PCOS4807480010948100160204
–7037480010945
Syndrom767748001094585136187217266342
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ovarií1705748001094992136166187208
GnRH4807620010958109158217
–7147620010944
Gonadotropin7757620010958109159203254304334363413464486536
Releasing1327762001094995116162206241262312363
hormon17067620010950100130206256306
FSH480776001094487145
–6447760010945
Folikulostimulační708776001094493115136179229250300336367388463513534578618668689
hormon14167760010950100130206256307
LH22807060010942101
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Luteinizační2464706001094392122167188239260298344384434455
hormon29387060010950100130206256307
AMH22807200010955128188
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Anti–Müleriánský25517200010955105134155202276326347393423445488538573616661
hormon32317200010950100130206256307
SHBG22807340010944103152211
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Sex2574734001094490133
hormone27267340010950100130206256306352
binding3097734001095173123174196246296
globulin3413734001095071121173223245266316
DHEAS22807480010960119164221266
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Dihydroepiandrostendion2630748001095981131173223253302348400422465515567596646681712757807859880930980
COC22807620010951111164
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Kombinovaná252876200109194896170220241290339380423472515
hormonální3058762001094998127201250299341362411431
antikoncepce35047620010943921201411822292792528776001094085137178222
DECLARATIONS:4068227008648871301662142563043393604124625014570227008514
Declaration406824100874987120141179206244271291333375
of445724100874066
originality:45372410087406888130150192230251271298337356
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manuscript418825200855891130168195227249266306329
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compliance:463327700873173134177197218256298330368387
The406828800853678116
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attest44642880085356087124153179
that466428800852465101126
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by406829900854073
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Committee464829900854179139198215239265300337
and500229900853373113
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welfare512831000855391110133170196234
regulations53903100085236110414516420140683210085234080120148
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authors’44343210085347397136176200229244
institutions46983210085165684109126150189213231270310338
as505632100853462
well513832100855187104122
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World406833200856099124142184
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of528833200853961
Helsinki537033200854684102131149189224243
on406834300854082
Ethical418534300853561104123157195214
Principles44343430085386383125160179222242281311
for47803430085216389
Medical490434300855897141160194232251
Research519034300853978108147184210244287
ing551134300851759102
Human406835400854685145179219
Subjects430735400853474114132168201227256
adopted458335400853474114155179215256
by485835400854074
the49523540085236399
18th507135400853669514135400501437
WMA5198354008559116160
General537835400854582122158182217235
Assembly406836500854475105143204247266302
in439336500851758
Helsinki,447436500854785104134152193228248264
Finland,47613650085355394113149190232249
in503336500851758
June511536500852667109147
1964,528536500853771110150166
with54743650085537297139
subsequent406837600852867107136172213252288328352
amendments,443737600853493130169210269305345369398414
as486837600853462
well494837600855287105122
as508837600853362
with51673760085526993133
the53183760085236298
ICMJE543437600851759116143179
Recommendations406838700853977112153216278317359402439465483525568598
for46973870085226389
the481838700852466104
Conduct,495438700854283125168210245272290
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2018,503740900853673107140156
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