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PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
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biomarkery5503600106345192146187222258290326362
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kazu119236001063475110151
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biomarkery10489200298144208345549675764891101311041233
zubního23309200298112251393533597740877
kazu32559200298130257367506
prof.3401320013766108171209235
MUDr.5971320013793168245288311
Vlasta9301320013770100159206247305
Merglová,12581320013793151194258289352409467496
CSc.17761320013766125175205
Stomatologická340148001335488147239291326385411472534559607658712
klinika1075148001335279103164189239293
Fakultní13911480013354102153214239275335360
nemocnice17741480013361116208268318378403452505
a23031480013353
Lékařské23791480013352106158211246290341394
fakulty2796148001333386137197223258313
v31321480013353
Plzni,3208148001335983130190215237
Univerzita34691480013371131156208262297346371407461
Karlova39531480013360113149174235286339
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Praze4391148001335993146194248
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kaz603199001214796139
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je946199001212474
jedno1039199001212474131187242
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infekčních2432199001212479108158205249304327372427
onemocnění28771990012155111161245300345401451506530
dětského34251990012156106140180227276331386
věku.340213001214795140194214
Kromě571213001215386139220269
nadměrného8572130012154101156237286318372421475529
příjmu1402213001215688110134215268
sacharidů1687213001213886129183229261283338391
a20952130012147
přítomnosti2158213001215688110142195276330384422454476
zubního2651213001214295151205227282336
mikrobiálního30032130012182105150183236291314360383436458514567
plaku3587213001215679125170224
se340227001213989
za447227001214292
další5562270012156104127165188
významné761227001214898143198245328382432
rizikové121122700121325598121167220267315
faktory1544227001212977124159212245295
vzniku1856227001214893148170216271
ZK21452270012154107
pokládá22702270012156112158183231287334
složení2622227001213962117158208263285
tvrdých2925227001213383116171218262316
zubních3259227001214297153208231275330
tkání3606227001213379128182205
a3402410012148
sliny.41524100121396386141186203
Slina64424100121507396151199
odráží8702410012154112144193236259
fyziologický1156241001212980125148203227282339362407453504
a16862410012148
patologický17612410012157106138192216271328351396442493
stav2280241001214074123169
dutiny24762410012156111144167222268
ústní2770241001215594128183206
a30032410012148
hraje3078241001215588136160210
významnou3315241001214898143199247330385440496
roli340255001213387111134
při500255001215790114
vzniku640255001214893148171218273
a9402550012148
prevenci1014255001215790140187236292337360
zubního1400255001214398155211234291346
kazu.1772255001214796140195216
Možnými20142550012180136178233279363386
biomarkery2427255001215780135219267299346395428479
zubního2932255001214398154210233291346
kazu3304255001214796139194
je3525255001212474
řada3626255001213281137185
měřitelných3402690012183134166189222271295350396440495
vlastností854269001214872120159193249304343377400
sliny127326900121406386141187
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množství15492690012183138193236277311361385
sliny,195326900121406386141187203
pH21752690012157123
sliny,231826900121396385141186202
pufrovací25402690012157112142175230277325370393
kapacita,2952269001214796153202247270303352373
přítomnost3344269001215790113146200284339394434467
a3402830012148
množství4082830012183139194236277311361385
kariogenních813283001214796129152207264314370425448493548
mikroorganismů.13802830012184107154188242298331387435490513552635689710
Hlavními2109283001216689137184240263346370
složkami2498283001214063118160207257340363
sliny288028300121406386141187
jsou3086283001212563119174
voda32802830012148102159207
a35072830012148
různé3575283001213288130186236
anorganické3402970012148103159191247295350373418465513
a8812970012148
organické956297001215588144192247270315361410
substance.1393297001214094151190224273328373422442
Za18622970012156105
významné1994297001214899144199247331386436
organické2458297001215487143191246269314360409
látky2895297001212371104150201
se3123297001213990
považují32402970012157113160208252307330354
antimikrobiální362129700121481031361593403110012183107153187242299323371394449472
peptidy,8383110012157108165199222278326342
slinné120631100121406386141196247
glykoproteiny1479311001215679127174228285318373405455478533579
a20843110012148
proteiny2159311001215790144177226250305351
s25363110012139
enzymatickou26023110012150105148198283331363386431477531586
aktivitou.3215311001214895131154202226259313368389
Tyto3630311001215091128181
látky340325001212472104151201
mohou5613250012183139194250305
sloužit886325001214063118173216240273
jako1179325001212472119172
zdroj13713250012143100132187210
biomarkerů1601325001215781136220268300347396429484
pro2105325001215790145
stanovení2270325001214073122178233280329385408
rizika269832500121325699122169218
vzniku2936325001214893149172218274
zubního3230325001214298154210233290345
kazu.3595325001214797140195216
Slinné34033900121507498154211262
biomarkery631339001215883139224273307355405439490
mohou11503390012185141198255311
být14903390012158106143
využity16623390012149101158202226260311
nejen20023390012156108133184241
pro2272339001215892147
predikci,2449339001215791142201224272317340362
diagnostiku,2840339001215781130187244300340375399446503524
prognózu3393339001215892148206262319361418
a3403530012148
ošetřování404353001215593142175206259305353407429
zubního850353001214296152206228284338
kazu,1205353001214695137191211
ale1433353001214770119
i15693530012123
pro1609353001215688141
hodnocení17673530012155109165219273317365420442
výsledků2226353001214797135158207263309363
léčení.2606353001212372117164219241261
Cílem2884353001215779104153235
dalších31363530012155102125163185228282
výzkumů3435353001214897141187241323376
bude3403670012156111167217
charakterizovat574367001214498146178225271307355387410453506553601632
vztahy1224367001214792127175229274
mezi15153670012183133175198
jednotlivými1731367001212473130184238271293316363413496519
proteiny,2268367001215688142174223246300345361
jejich264636700121247497120164218
interakce2881367001212378110158190238284327375
a32743670012147
určit,3339367001215486130152184205
jakým3561367001212472117167250
způsobem3403810012143100155194249306357441
ovlivňují8023810012155102126149198254308332355
vznik1178381001214893149172218
a14183810012148
progresi1487381001215790144201234283323346
zubního1854381001214398155211234291346
kazu.2221381001214796140195216
Klíčová340397001246087113156211261312
slova:666397001244269124174225248
zubní929398001214295149203224
kaz,1168398001214693134154
slina,133739800121396081134180199
slinné155139800121396182135187236
peptidy,18013980012156105160191212266312326
slinné214239800121396081134187235
proteiny,2392398001215687139170217239292335350
riziko275639800121325495116161212
vzniku2983398001214790143164209262
zubního3260398001214295149202224278331
kazu.3606398001214693134187206
Salivary3404250012454107135163216269308363
biomarkers723425001246088146232285324378430469513
of1256425001245892
dental13694250012459112172208262290
caries1679425001244599137164218262
Dental3404430012166115169200247269
caries624443001214491122144193231
is870443001212360
one9454430012155109157
of1118443001215482
the1215443001213386135
most13654430012183136174206
common1586443001214496178259313366
chronic1968443001214497128181235256299
infectious2283443001212376104152196230251304358395
diseases2693443001215678115164210248296334
of3042443001215582
childhood.3140443001214497119140195249302356411431
In3586443001212477
addition36784430012148103340457001215576107128181234
to588457001213384
excessive686457001215094135182219256277323369
sugar1070457001213890144189219
intake1304457001212375106152196243
and15614570012147100154
presence1729457001215687134171219272315361
of2105457001215380
dental22004570012155103156186232254
microbial24684570012182103145176227282304349370
plaque,2853457001215578123177229277295
other3162457001215485137185216
risk339245700121325490134
factors3540457001212976118151202233271
related340471001213381104151183231287
to644471001213386
dental7464710012157106161192240262
caries1024471001214593124147196235
are1275471001214879128
the1420471001213387136
composition1573471001214497180235290329350383405459513
of2103471001215583
hard22024710012155102134189
dental24074710012157106161192240262
tissues268647100121335592130184233272
and29744710012148102158
saliva.3148471001214088110132180227247
Saliva3412471001214997119141188236
can3664471001214592147
reflect340485001213381110135184228262
the618485001213387136
physiological7704850012156111155193215269292345401423466514536
and13224850012148102157
pathological14954850012156104135189243265319375397440487510
state2020485001214072120151199
of2235485001215583
the2333485001213387136
oral2485485001215586134156
cavity2657485001214492137159191240
and29134850012148101157
plays3086485001215679126170208
a33104850012148
crucial3374485001214576130174195242264
role3654485001213286108158
in340499001212378
the435499001213387136
initiation58949900121237799131153200232254308362
of968499001215583
dental10694990012156105160191239261
caries1348499001214492123146195234
and15994990012148102158
protection1774499001215789142174222267301323377432
against22234990012148104151173227265298
dental25384990012156105160191239262
caries.2817499001214492124146195234254
Many30884990012181128182227
measurable33324990012183133180218272303351406430479
characteristics340513001214599146177225269303351383406443476498542582
of946513001215583
saliva1054513001213987110131179226
are1305513001214879128
potential14585130012157112143192246278300346369
biomarkers1851513001215780134217264295341389421460
for2336513001212983115
dental24755130012157106161192240262
caries2762513001214592124146195234
–30205130012150
salivary3095513001214088110132179227258308
flow3427513001212955109181
rate,3632513001213380112160179
salivary340527001214088110132179227258308
pH,6725270012157122142
buffering8385270012157111140172221253275329384
capacity,1247527001214592148196239261293342357
evaluation1629527001215096144166220267298320374429
of2082527001215583
the2190527001213387136
presence2351527001215688137176225280324372
and27475270012148102158
amount29295270012149131185239294325
of3278527001215583
cariogenic3385527001214593124147201256306361383426
bacteria.3405410012157105148183231263286332352
The7125410012149105154
major8855410012184131153208239
salivary1144541001213987110132179226258307
components1470541001214598180236291346395450481521
are2010541001214879128
water21575410012174121153201233
and24095410012148102158
various,2586541001214896127150204258296316
inorganic2921541001212478132164219266320342386
and33265410012148102158
organic3503541001215587141188243265308
substances.340555001214093149187220268322366414453473
The8345550012150105155
most10105550012184138176209
important12405550012124106162217249284331386417
organic1678555001215587142189243265309
components2008555001214598180236291346395450481521
of2550555001215583
saliva2655555001213987110132179226
comprise2903555001214597180236268290328377
antibacterial33025550012148102134156211259303337385417440487509
peptides,3405690012157107163195217273322361381
salivary737569001213987110132179227258307
glycoproteins,1061569001215678124167220276308362393442464518556576
salivary1653569001214088110132180227259308
proteins1977569001215789143174223245299337
and23305690012149103158
proteins2505569001215789142174222245299337
with2858569001217396128182
enzymatic30575690012150104146195279326357379423
activity.3496569001214892126148196219251300315
These3405830012149104153191240
substances596583001213992147185218265319362410448
can1059583001214592146
serve1220583001213988120170217
as1453583001214885
a15545830012148
source1617583001213993147178221268
of1901583001215482
biomarkers1999583001215679132214261292337385416455
for2469583001213083114
caries2599583001214592123145194232
risk284658300121335592137
assessment.2999583001214885123172210248329378432463483
Salivary3498583001214896118139186233264313
biomarkers340597001215779132214261292337385416455
may8115970012182129173
be10005970012156106
exploited1121597001215096152174228250282329385
for1522597001212982113
the1651597001213386135
prediction,1802597001215688136192214257291312366420439
diagnosis,2257597001215678124178232286324345382402
prognosis2675597001215688141196250303341363400
and30905970012148102157
management32625970012183130184230285333415464518549
of340611001215583
dental4426110012157106161192240262
caries,724611001214592124146196234254
as998611001214886
well11036110012174122145168
as1290611001214886
for1396611001212983115
evaluating1530611001215197145167221268299321376431
the1980611001213387137
outcome21366110012155110142184237320369
of2525611001215583
therapeutic2627611001213387137169216272322376408431474
regimens.3121611001213281137159241291346383404
Future35446110012149101133187218267
research340625001213381120169217248291345
is705625001212361
essential785625001215189127177231263285331354
to1158625001213386
characterize1264625001214599146177225269303351383405447496
the1780625001213387136
interaction1936625001212378109157189237280315337391445
of2401625001215583
salivary2503625001214088110132180227259308
proteins,2830625001215789143175223245300337358
and32076250012148102158
determine33856250012156105138186218301323377427
how3406390012155110181
these541639001213387136175224
affect784639001214977108157202236
the1040639001213387136
initiation119663900121237799131153200232254308362
and15786390012148102158
development17556390012156105152200223277333416466520552
of2326639001215583
dental24286390012157106160192240262
caries.2709639001214593124147196234255
Key3406550012463116170
words:5416550012477136177240286314
dental8876560012158110168203254279
caries,1198656001214697131157209251274
saliva,1504656001214091117141192243266
salivary1801656001214192117142193244278331
peptides,21646560012158111171206231290343385408
salivary2603656001214092117142193244278331
proteins,2965656001215893151185237263320361384
caries3381656001214596131156209251
risk3663656001213459100149
assessment.340670001214888128180220260344396453486508
Úvod3407170014780142208279
Zubní4807340010951100152203223
kaz728734001094388128
(ZK)880734001092676125153
je1057734001092369
chronické,1150734001094191121171222243283326370388
mikrobiální,1563734001097798140171221273295338360410431449
sacharidy340748001093680120170213242263314357
potencované7217480010951102131175225266314356400450495
multifaktoriální12407480010976125146175196222266308340389418439482503553573
onemocnění183774800109501001463407620010977128169220266317339
vznikající703762001094586137158201246268289330351
na1079762001095195
základě1199762001093985128151195247293
poruchy15177620010952104134185226277319
rovnovážných18607620010930811243407760010951103147192232283326366418
procesů784776001095384134177222259310
demineralizace1120776001095399177199250297327373394416456502543589
a17367760010944
remineralizace18077760010930771541762140720001095095125168189209248292332376
na2540720001095093
povrchu26577200010952102144174213263312
tvrdých2993720001093075105155198237286
zubních3303720001093988139189210249299
tkání3626720001093071115165185
(1).214073400109266888104
ZK2269734001095199
má23937340010976120
společné2537734001093788139161207248299345
rizikové290673400109305190112154203246291
faktory3221734001092772114147196226272
s35177340010936
jinými357873400109224394135212233
nepřenosnými2140748001095197149179224275325360411452529550
nemocemi,2715748001095096173223264309385406425
v31647480010944
jejichž323374800109226890111151202241
etiologii349874800109467697147169220271292313
hraje2140762001095079123144189
významnou2353762001094489130180223298347397447
roli2824762001092978100120
nadměrná2968762001095094145220265294344388
konzumace3380762001094290141179229304347387431
sacharidů,2140776001093679118167210238259309357375
jako2529776001092265106153
jsou2697776001092156105154
kardiovaskulární2865776001094285114164184233274317352393442462505533582603
onemocDECLARATIONS:34827760010949981432172663074068201008648871301662142563043393604124625014570201008514
Declaration406821400874987120141179206244271291333375
of445721400874066
originality:45372140087406888130150192230251271298337356
The406822600853473109
manuscript418822600855891130168195227249266306329
is452822600851744
original45832260085386178117133172205222
and481622600853472112
has49392260085387299
not50502260085387699
been516122600853975110149
published532222600853977117134150177216251291
or406823700853862
submitted414523700852867108167184208234269310
elsewhere.44702370085355381117169209245269305320
Ethical406825000873764107127160198218
principles43002500087427090132165185228249287319
compliance:463325000873173134177197218256298330368387
The406826100853678116
authors420526100853475100142183208238
attest44642610085356087124153179
that466426100852465101126
their481126100852465103121146
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approved531226100853577120145186221258301
by406827200854073
the41582720085236399
local42742720085175689124141
Ethical44322720085345898115147182199
Committee464827200854179139198215239265300337
and500227200853373113
is513227200851745
in519427200851656
compliance526727200853169129169187204239278311346
with40682830085537298140
human423628300854081143180221
studies44862830085285596139157195226
and474028300853577119
animal48882830085347695156193212
welfare512828300855391110133170196234
regulations53902830085236110414516420140682940085234080120148
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