610
www.pediatriepropraxi.cz3408040010765133201214264309359378418445472491535585612659709736777817836852893931
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praxi.3928804001075077118158177193
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PRO5216804001074591154
PRAXI5391804001074692148201221
2756558020012657113
PŘEHLEDOVÉ4549200012660124182256312369444520587645
ČLÁNKY5216200012660115187259327395
Význam305236001063675109150190245
a3312360010638
rizika33663600106335184101137179
enterobakterií356036001063071104136172212248289324358390426444461
pro403736001063268108
zdravý416136001063170106148183222
vývoj439836001063775116155178
střevní45923600106306399131171212229
mikrobioty483736001065269105141181218235276307346
novorozenců519836001064080118157193234265297338373414
Význam3409200298153277392533658862
a12509200298127
rizika1425920029892155266332460587
enterobakterií20609200298127267352477567705847972110011921317140814711534
pro36439200298143233371
zdravý40629200298113255344468589720
vývoj48309200298127258391524590
střevní34011800298104191282407530670734
mikrobioty11221180029820727139949262977183597210591188
novorozenců235811800298141277399532622759869995113512411379
Ing.340158001373196160189
Jan5511580013745103168
Vinkler1,7411580013770100165224256314356109515900803611301580013729
Ing.1181158001373196160189
Nikol13921580013776106166228259
Modráčková,16731580013793157223265322372432494550608638
Ph.D.1,23331580013764127156234260258615900803626201580013729
MUDr.26711580013793168245287310
Peter30031580013764121162220262
Korček,32871580013768129171220278338370
Ph.D.2,36791580013764127156235261394215900803639801580013729
prof.3401730013766108171209235
MUDr.5971730013793168245288311
Zbyněk9301730013763128184250308368
Straňák,1320173001376099142199263321381412
CSc.,17541730013766125175205234
MBA2,20111730013793160231224217400803622801730013729
doc.23311730013765129179209
Ing.2562173001373196160189
Věra27731730013770125167225
Neužil30201730013776134199251282312
Bunešová,33541730013767131195253302365422480509
Ph.D.1388517300137641281572352614139174008036
1Katedra3401890078333711890013360113149202265300353
mikrobiologie,7481890013391116167204264326352412438498560585640661
výživy14331890013352108157182235290
a17461890013353
dietetiky,1823189001336287141178232268293344399416
Česká22621890013364117160211264
zemědělská25501890013347101193248310365391433484538
univerzita31111890013360121146198252288336362398451
v35851890013353
Praze,3661189001335993146194248270
Praha-Suchdol3954189001335893146206259293345404453513575635661
2Ústav3402040078333732040013371113150203254
pro650204001336298158
péči8312040013363119168193
o10472040013361
matku11312040013392144179230291
dítě,1445204001336287123176198
Praha1666204001335993146206259
Mikrobiom3402550012180104151185239297320375459
střeva827255001213973105155203251
hraje1106255001215688136160210
klíčovou134425500121477295140193240294350
roli1721255001213388112135
v18832550012148
dlouhodobém1959255001215780135190246301358413470521605
fyzickém2592255001212980125148193239288372
i29922550012123
psychickém3043255001215796144188243266311357406490
zdraví3561255001214299131180226250
člověka.340269001214467121167216262310331
Jeho688269001213787141196
vhodné9012690012147103157213267317
složení1235269001213962116158207262284
během15362690012157107162211294
počáteční18472690012156111156204235284329383405
kolonizace2270269001214699122177231254296345389437
gastrointestinálního27242690012156103141174206260283337369417456489512566613636690713769823
traktu3564269001213365113159194248
novorozenců3402830012156112159214247302345395452497552
s9212830012140
dostatečným9902830012156112152186236269318365420466551
zastoupením1570283001214394133167222278335387443467551
taxonů2149283001213483131185242297
s24752830012139
komenzálním25432830012147102186237294337388411467490575
či3146283001214569
probiotickým3243283001215891146204228284317340385432483568
potenciálem3402970012157113146195251296319366390440524
je882297001212474
zásadní974297001214393132181238293316
pro1308297001215790145
obranu14712970012155112145193248303
před1792297001215790140197
infekcemi2007297001212379107158205249298381404
a24292970012149
správný2496297001213996129177224280326
vývoj2840297001214898150204228
imunitního30862970012123106161216239273328351408463
systému.35672970012140881281612113403110012183138159
Enterobakterie5243110012149103136185218272330378425461510543566617
tvoří1165311001213384138171194
nedílnou13843110012155105163186211266321377
součást1785311001214095150195244283317
střevní2126311001214074106156203259282
mikrobioty24333110012183107153187242299323378410460
a29183110012148
mají29903110012184132156179
klíčovou319331100121477295140193240294350
úlohu3567311001215579134190244
v3403250012148
počáteční4063250012157113158206239288333388411
kolonizaci8353250012147101125180235258301351395418
střeva1271325001214074106155203251
novorozence.15403250012156111158211244299340390446491540560
Zároveň21183250012155104136191238287342
se2478325001214090
jedná2586325001212474132187235
o28393250012154
potenciální29113250012157113146195250295318366389444467
patogeny,33963250012157106138192248299354400416
které340339001214681129160209
mohou5653390012182136190244298
způsobovat879339001214298152189243299353399446477
závažné1373339001214291136183225279328
infekce.1717339001212377105154200242289309
V20423390012155
článku2114339001214466112166211265
jsou2396339001212461115169
popsány25823390012155110165204251305349
funkce2948339001212883137182224272
enterobakterií32363390012150104135183215268323371416451499530553575
v3403530012147
mikrobiotě4043530012182104149182235290313366398446
kojenců,866353001214698121170224268321340
rizika122335300121325596118164211
spojená1451353001213994148171219274320
s17883530012138
jejich184335300121247395118161214
nadměrnou20743530012154101156237286317372425479
přítomností2569353001215688110142195276330383421454476
a30613530012148
strategie3125353001213972103150182229284307355
prevence3497353001215687136182229284340368001214492
infekcí.448368001212377105154200242264284
Dále7483680012166112135184
jsou949368001212361115169
diskutovány1134368001215678116161215247299345392446490
faktory1641368001212976121156209241290
ovlivňující19473680012154100123145192247300323345388410
formování2374368001212982114196249295342396418
mikrobioty28093680012182104149182236291314367399448
u32733680012154
dětí,33443680012156104137159178
včetně3539368001214789137169223272
způsobu340382001214299153192246303358
porodu7153820012157112144198255309
a10413820012148
vlivu110738200121477194141196
antibiotik.13213820012148102134157213236290323345391414
Výzkumy17523820012155103148194249331376
ukazují,21463820012154100149192246270292312
že2476382001214292
podpora25853820012156112168224280312360
přirozeného2963382001215688111143197239288343393448502
porodu,34833820012156112144198255309329
kojení3403960012147101124175230253
a6193960012148
použití6933960012157112168211234267290
probiotik1009396001215790144201225280313336382
mohou14173960012183138194249305
pozitivně17473960012157113155178211234283339389
ovlivnit21623960012155102126149197253276309
střevní2497396001213973106155203259282
mikrobiotu28053960012183106153187241299322377410465
a32953960012149
eliminovat336939600121507497180204259314361410442
potenciální3404100012157113146195251296319366390445468
rizika82941000121325699122169218
spojená1067410001214096152176226282330
s14184100012139
enterobakteriemi.14784100012150106138187220275332381427463512545569619703726747
Článek2245410001215881129184235282
poskytuje25484100012156112152198248285340363414
přehled2982410001215790140196219269327
současných3329410001214095150195244283338383427482
poznatků3404240012157113155210258291337392
o7544240012155
enterobakteriích8304240012150105138187220274332380427463512545569592636691
v15424240012149
mikrobiotě16124240012183106153187242299322377410459
kojenců20934240012147100124174230275330
a24444240012148
zdůrazňuje2513424001214399154186235278334388412462
potřebu29964240012157113146179228285341
dalšího33584240012156104128166189247302
výzkumu3681424001214899340438001214390145228283
a6444380012148
sdílení714438001213996119144195250274
nových10094380012155110157208252307
poznatků13374380012157113155210258291337393
v17514380012148
klinické182043800121477295150173218264313
praxi,2154438001215790139186210230
aby24064380012148105151
byl25784380012157104128
zajištěn2727438001214393116140178212261317
zdravý3065438001214399131180226277
vývoj3363438001214899151205228
dětí.36134380012156106139162183
Klíčová340455001246190118163220272325
slova:684455001244371129181234260
enterobakterie,9634550012150106138187220275332381427463512545569619639
mikrobiom16214550012184107154188242299323378462
novorozence,21024550012155110158212244299341391446491540560
kojenecké26824550012147100124174230281326373422
infekce,3123455001212379107158205248297317
imunitní34604550012123106161216239272328351
systém,340469001214088127161210294315
počáteční6764690012157113158207239288334389412
kolonizace,11094690012147101125180236259302352396445465
antibiotická15964690012148103135158215239294326350394441490
rezistence.2107469001213383126149188222271327372421441
Importance3405000012428115175234272311365424469522
and8825000012453111171
risks1074500001243865109163210
of1304500001245892
enterobacteria14175000012452112148201240299359412457496549588615669
for2106500001243492130
healthy22575000012458111165193230290341
development26185000012459113165216245303363450503563599
of340514001245892
newborn4535140012458111187248306344403
gut8765140012459118155
microbiota10515140012486114159198256316344402440493
The3405310012149104153
gut5095310012155109141
microbiome6665310012182105148179233288311364446495
plays1178531001215679126170208
a14035310012147
key1467531001214694139
role1622531001213386109158
in1796531001212377
a18905310012147
person’s19545310012156105137176230284303338
long-term2309531001212377131186216249297328410
physical27365310012156110154193215258305328
and30805310012148101157
psychological3253531001215694141184237291314368423445488536558
health.3405450012155105152175208262283
Its64154500121235696
appropriate7545450012148104161193247304336359407439487
composition1259545001214497180236291330353385408462517
during17945450012156110142165220275
the2086545001213388138
initial2241545001212378101133156203226
colonization2485545001214497121175230253295344376399453508
of3011545001215483
the3111545001213388138
gastrointestinal326654500121561031421752072612843393714194584925143405590012155102125
tract482559001213264112156190
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newborns7895590012155104176233287320375412
with1218559001217396129183
the1418559001213387136
sufficient1571559001213993121153179223245294349380
representation1968559001213382138170219258307362393441473495549604
of2589559001215483
the2689559001213287136
taxa2842559001213381127175
with3034559001217295128182
commensal3233559001214497179261311365403451474
or3724559001215487
probiotic340573001215689142198221276308330374
potential7315730012156111144192247278301348371
is1119573001212361
essential1197573001215088127176231263285332355
for1569573001212983115
defence17025730012155105134183238282330
against20495730012148103151173227265299
infections2365573001212377105155200234257311366404
and27865730012147102157
proper2961573001215688142198248280
development32595730012155105151200223277334416466521552
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the439588001213286135
immune5915880012123104185238292341
system.949588001213986124157205286307
Enterobacteria12725880012149102133181213266321369412446494526549595
form1884588001212882114196
an20965880012148101
integral2214588001212377108156211243290312
part25435880012156103135169
of2729588001215482
the2828588001213286135
intestinal2979588001212377108156195227250303350372
microbiota33685880012182104148179232288311364396443
and3406020012148103160
play522602001215781129175
a7196020012148
vital790602001214871105153177
role989602001213387111162
in1173602001212378
the1274602001213388138
initial1435602001212378101134157205229
colonization1686602001214598122177233256299349381404459515
of2223602001215584
the2329602001213389139
newborn24906020012156106179237293326381
gut.28946020012155110144165
At3081602001216192
the3196602001213388138
same3357602001213988171222
time,3601602001213356139190210
these340616001213388138177228
are585616001214981130
potential7336160012157113145194250282305352376
pathogens11266160012157106138193248304354410448
that1592616001213388136168
can1778616001214593148
cause1944616001214493147186236
serious2198616001214090122146201256295
infections.2510616001212479107157203238261316371410431
This29596160012149105128167
article3143616001214981117139184207257
describes34186160012156106145190223246302353393
the340630001213388139
functions498630001212985140185221244299355393
of911630001215584
enterobacteria10146300012150106138187220275332381426461510543567614
in1648630001212378
the1746630001213388139
microbiota19046300012183107151184238296319374407456
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infants,2483630001212378107156211244284305
the2808630001213388139
risks296663000121335695141184
associated3169630001214988127182227250298331380437
with3626630001217397130185
their340644001213388139162195
excessive559644001215097141190229268291339388
presence,971644001215790140180230286331380400
and13956440012148103160
strategies1578644001214074106155187237294317367406
for2008644001213084117
preventing2149644001215790140188237292325348403459
infections.2632644001212379107158203239262317372411432
Furthermore,30886440012149102134170225276309392448481530550
factors3662644001212978123340658001213387120160
affecting523658001214877110160205241264319375
microbiota9216580012183106151183238295319374406455
formation1399658001212984117201249281304359415
in1836658001212479
children19376580012145100123147203236285341
are2301658001214880130
discussed,2453658001215780119164219258297347404425
including2901658001212378123146201258281336392
the3316658001213388138
delivery34776580012156106130153202251284334
method3406720012183134167223278335
and6996720012149104160
the884672001213388138
effect1047672001215080112162208243
of1315672001215584
antibiotics.14236720012148104136159216239294327350395435457
Research19046720012154105144195243275319374
shows2303672001213994149222262
that2589672001213388136169
promoting2782672001215790145228284316339395451
natural32576720012156104136191224272295
childbirth,35776720012145100123146203340686001215781113149204225
breastfeeding,593686001215790139187226260292342393450474529585606
and12276860012148103160
probiotic1415686001215790144201225280313336380
use1823686001215594145
can1996686001214593149
positively21736860012156112152175208231279328352400
influence2600686001212479108134189239295340389
the3017686001213388139
gut31846860012156110144
microbiota33556860012184107152184239296320375407456
and3407000012148103160
eliminate52270000121517598181204259307340389
potential9337000012157113146195251283306354377
risks133370000121335695141184
associated1539700001214887126182227250298331380437
with1998700001217498131186
enterobacteria.22067000012150106138188221275332381426461510543567615636
The28647000012150106157
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an37077000012149104
overview3407140012155101150183233257307379
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current838714001214499131164213268300
knowledge11567140012146103157230253303360416466
about16397140012148104160215248
enterobacteria19047140012150105137186219273329378422457506538562609
in2531714001212378
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microbiota27817140012183106151183237293317371404452
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and36517140012148103159
highlights340729001215578134190213236292347379420
the778729001213388138
need9347290012156106157215
for1167729001212984116
further1301729001213085118154209259292
research1611729001213382122172220253297352
and19817290012148103160
the2159729001213388138
sharing2315729001214095143175199254310
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knowledge29427290012147104159232255306363419469
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to696743001213488
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the1107743001213388139
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development15997430012157107155204228283340424474530562
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children.2288743001214499122146202235285340361
Key3407590012461112164
words:5207590012476133171231274300
enterobacteria,8387600012150105137186219273330378423458507539563610631
newborn14877600012155105178235290323378
microbiome,18837600012183106151183237294317372455505525
infant2426760001212378107155210242
infections,2686760001212378107157202237260314370408429
immune31337600012123106189243298348
system,3499760001213987126160209292313
initial340774001212379102135158206229
colonisation,590774001214599123178233256295344377400455510531
antibiotic11427740012148104136159216239294327350395
resistance.1558774001213383122145184218266322367416436
DECLARATIONS:4068257008648871301662142563043393604124625014570257008514
Declaration406827100874987120141179206244271291333375
of445727100874066
originality:45372710087406888130150192230251271298337356
The406828200853473109
manuscript418828200855891130168195227249266306329
is452828200851744
original45832820085386178117133172205222
and481628200853472112
has49392820085387299
not50502820085387699
been516128200853975110149
published532228200853977117134150177216251291
or406829300853862
submitted414529300852867108167184208234269310
elsewhere.44702930085355381117169209245269305320
Ethical406830700873764107127160198218
principles43003070087427090132165185228249287319
compliance:463330700873173134177197218256298330368387
The406831800853678116
authors420531800853475100142183208238
attest44643180085356087124153179
that466431800852465101126
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by406832900854073
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Committee464832900854179139198215239265300337
and500232900853373113
is513232900851745
in519432900851656
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