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charakteristiky105236001063273113148190226260292328345378410428464503
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aorty114111800298127263353443572
prof.3401580013766108171209235
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MUDr.20501580013793168245287310
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Ph.D.2,31941580013764128156235261345815900803634951580013729
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Ph.D.3,50221580013764128156235261528515900803653221580013729
MUDr.3401730013793168245287310
Kamila6721730013768126221251281339
Michálková2103317300137931241742382963263864485055631595174008036
1Ústav3401890078333711890013371113150203254
molekulární6481890013392152178233284345370422458519543
a12151890013353
translační1291189001333672125185227252305353414438
medicíny17531890013392147209234283308368418
LF21941890013352105
UP23221890013371129
a24751890013353
FN25511890013354124
v26981890013353
Olomouci27741890013376102163254314375424449
2Dětská3402040078333732040013373128165209260313
klinika710204001335178103163188239293
LF10262040013352105
UP11542040013371129
a13072040013353
FN13832040013353123
v15302040013353
Olomouci16062040013376102162254314375424449
3Radiologická3402190078333742190013359112174199259285345407432481531585
klinika982219001335279104164189240294
LF12992190013352105
UP14272190013371129
a15792190013353
FN16562190013353123
v18032190013353
Olomouci18792190013376102162254314375424448
Syndrom340270001214993148204235289371
střední734270001214073104153209263285
aorty10432700012148102134169218
(MAS)12842700012128106166215242
je1549270001212473
způsoben1646270001214298153191245301351406
stenózou2075270001213972121175229270324378
hrudní2476270001215687141197251274
a/nebo2773270001214882134184240295
břišní3091270001215789111149203225
aorty,33392700012148102134169218233
často3595270001214593131163216
doprovázenou3402840012156110167199252298346388437492546600
současnou963284001214094149192240278332386440
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renálních1828284001213382136183206260282325379
nebo22312840012155105161216
viscerálních2470284001214871109153201233280302357379422476
tepen.2969284001213482138188243263
Ačkoli32552840012161104149202225247
je3525284001212474
MAS36222840012180141190
vzácný340298001214994144188244289
(0,5–265729800121287898151202249
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je1068298001212575
závažnou1170298001214494140189232288343398
příčinou1595298001215891114158181236292347
hypertenze19692980012157102160211244280329385428478
u24742980012156
dětí25572980012157108141163
a27482980012148
dospívajících28242980012157112151208231280328352374419442486542
s33932980012140
vysokou34602980012149100139194242295351
morbiditou.3403120012183137169225247303325357410464483
Předpokládá839312001215384132188244299345369415471518
se,1372312001214089108
že1496312001214291
vzniká1603312001214892146168213261
při1880312001215788111
selhání2007312001213988111165212266288
splynutí2311312001213994117164219272304326
obou26533120012155111165219
dorzálních28883120012157110142186234257310332376430
aort33333120012149102134169
během35183120012157106161210292
embryonálního3403260012150132188220269322376423445499521577631
vývoje,987326001214897148200223272291
a12943260012148
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procento1657326001215688142186234288319372
případů2045326001215788111166214269323
je2383326001212574
idiopatických.2473326001212378100154210257289311354399449491545565
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probíhá3383326001215789142198220276323
se3722326001213989
symptomatickou340340001214087170226258311393440472494538583636690
nebo10463400012156105161216
asymptomatickou1278340001214886133217272304357440487519541584630682737
arteriální2031340001214879114162194217264286340362
hypertenzí.24093400012156100157207239274322377419441461
Metodou28863400012180130162215272326380
volby32823400012148101124180225
je3523340001212474
dnes36133400012156110160198
angiografie,3403540012148101156177230285316363391415464482
neinvazivní8383540012155103125179224270312334381435457
MR13103540012180132
angiografie14573540012148102156178231286317364391416464
a19363540012148
CT19993540012158109
angiografie21233540012148101156177231285316363391415464
mají26023540012183129152173
podobnou27913540012156110166219274328382435
diagnostickou3241354001215678124178232285323355377420465517570
přesnost.340368001215789137176230284322355375
Ultrasonografie736368001216587119150198236290345399455486534562587636
je1393368001212473
primární1487368001215688111193240272327349
screeningovou1856368001214084115164214269291345400454500553607
technikou.2484368001213381126180234256302354409429
Léčba2933368001214796141196244
spočívá3197368001214095150195217264311
v35293680012148
kombinaci35973680012147100183340382001215779134181224246
různých602382001213387129183228271325
antihypertenziv.9433820012148102133155209254310360392427475530572594641656
Chirurgická16153820012158112134165219251305328371417465
léčba2096382001212373117172220
může23323820012183137179228
být25763820012156102137
kurativní.27293820012147101133180212233281336358377
Naším31223820012166114151174256
cílem339438200121446691140222
bylo36323820012157102126180
přiblížit340396001215789111167190212254276308
klinický66839600121467192147169212258307
obraz,9943960012155111143191233254
diagnostiku1267396001215779126181235289327360382428482
a17683960012149
léčebný1836396001212373117165221276321
postup21763960012157112150183237292
dvou24883960012156103156211
nových27183960012155109156205248302
případů3039396001215789111167215271324
s33823960012140
MAS.34413960012181141190210
Klíčová340412001246088114158214264316
slova:671412001244370126177228253
hypertenze,940413001215498154204236270318372414462481
syndrom1437413001213986140195227279361
střední1814413001213972103151207260282
aorty,21134130012147100132167215230
midaortální23594130012182104159206259291325373395449471
syndrom2846413001213985140195226279360
(MAS),32234130012128104164212238256
stenóza3495413001213972120174227267316
renální340427001213382138186210265288
tepny,649427001213382139195241257
děti.9274270012156106140163183
Clinical340454001245987115173201246300328
and6884540012453112172
imaging8804540012427113167226253312371
characteristics12714540012445105158196249294333386424452496533561607651
of1942454001245893
midaortic20554540012486114174227285323362390436
syndrome2511454001244397156216255313400453
Middle3404720012180104160216239289
aortic6474720012148102135171193238
syndrome903472001213987143199231285368419
(MAS)13394720012128106168217244
is1601472001212362
caused1680472001214593147186236293
by19914720012156103
stenosis2111472001214073122177232271294332
of2461472001215483
the2562472001213388138
thoracic2717472001213388143175224268291335
and/or30704720012148103159194244276
abdominal33644720012148104162216299322377425448
aorta,3404860012148103136172221242
often610486001215584120170225
accompanied863486001214993137191274331380435458508566
by14574860012157103
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the2620486001213388139
renal2787486001213282138186209
or3024486001215588
visceral3140486001214872111156205238287310
arteries.3478486001214881117166199222272312333
Although340500001216185118173228283339395
MAS7615000012180142192
is979500001212362
rare1067500001213382114164
(0.5–2%),125750000121287898152203250329354373
it1656500001212356
is1739500001212362
a18275000012148
serious1901500001214091123147202257296
cause2223500001214594148187238
of2487500001215584
hypertension25975000012156101159210243279328384423445500556
in3179500001212479
children32845000012145100123146203235285341
and36515000012148103160
adolescents3405140012148104159182232271316365420452492
with850514001217396129184
high1051514001215578134188
morbidity.12575140012183138170227250306329362411427
It1702514001212456
is1776514001212361
thought1855514001213388142197253308340
to2212514001213386
arise2316514001214880103142192
from2525514001212962116199
failure2742514001212978100123178210259
of3019514001215483
fusion3120514001212984123145200255
of3392514001215584
the3493514001213388138
two36485140012133109162
dorsal3405280012157112145186235259
aortas6275280012148104137173222261
during9175280012156111144168223280
embryonic12255280012150134191225275330386409454
development,17075280012157107155205229284342426476532565586
and23225280012148104160
a25115280012148
high2588528001215579135190
percentage28075280012157108141186235291324373429480
of3315528001215585
cases3428528001214594133184224
are3680528001214881131
idiopathic.340542001212380103158215264296352375419441
Clinically,809542001215881103159182226275298322369385
it1222542001212356
presents1306542001215790140179230285318358
with1692542001217497131186
symptomatic1905542001214088172229262316400448481504548
or2481542001215588
asymptomatic2597542001214887135219276309363447495527550595
arterial3220542001214880116166198222270293
hypertension.35415420012156101159210243340556001213382138177200255310331
The6965560012149106156
method8765560012184134168223278335
of1235556001215584
choice1344556001214499155178223272
today1640556001213387144192238
is1902556001212362
angiography,19885560012149104160183238295327376433489534550
non-invasive25625560012156111167199223278325373412435484533
MR31195560012180134
angiography32785560012148103159182237294327375432488533
and3405700012148103159
CT5165700012158110
angiography6445700012147102158181235291324372428483528
have11905700012155103149197
similar1405570001213962144167190238270
diagnostic1692570001215779127182237292331364387431
accuracy.2141570001214892135189222270314363379
Ultrasonography2538570001216487120152200239293349403459492540596651696
is3252570001212362
the3331570001213388138
primary3486570001215789113195243275325
screening340584001213984116165215270293347403
technique.760584001213381126181235258313367417437
Treatment1214584001214976125172204286336391423
consists1654584001214598153191213252285325
of1996584001215483
a20965840012148
combination2161584001214598180237260314362394416471526
of2704584001215483
various2804584001214896128151205260298
antihypertensive31195840012148103134157211256313364396431480535573596643692
drugs.340598001215688143199237258
Surgical6165980012149103135190213258306329
treatment962598001213366115163195277328383415
may13945980012183131176
be15885980012156107
curative.1713598001214499131179211234282330350
Our20815980012168124156
aim2255598001214770153
was24255980012174122160
to2603598001213386
present2707598001215689138178228283315
the3039598001213388138
clinical319459800121456891145168212261284
picture,3495598001215780125160214246296315
diagnosis340612001215680127183239294333356395
and7566120012148103160
treatment937612001213366116164196279330386418
of1376612001215584
two14816120012134109164
new16666120012155106179
cases1866612001214594133183223
with2110612001217397130185
MAS.23176120012180141192213
Key3406280012461113164
words:5266280012476133172232276302
hypertension,8516290012155101159210243279328384422445500556577
middle14516290012183106163219243293
aortic17676290012148103136172195240
syndrome,2030629001213988144201233288371422442
midaortic24956290012183106163211266299335358403
syndrom2921629001213987144200233287371
(MAS),33156290012128107168218245264
renal3602629001213383138186210
artery340643001214881117166199249
stenosis,610643001214074123179234273296335356
children.9876430012145100123146203235285341362
Úvod3406890014780142208279
Zúžení480706001095099139185236258
břišní756706001095182104140191213
aorty987706001094394124158204
poprvé12097060010951102155186233278
popsal15057060010951103155192237259
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v3407200010943
roce410720001093080122168
1848604720001094789138187
(1),81872000109266989107
ale952720001094366112
termín1091720001093075106183205256
syndrom1374720001093680132184215265342
střední174372000109356797143196247269
aorty340734001094392122154199
zavedl555734001093883124168220241
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80428776001094592
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(50–701205776001092569114162204248
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větve1575776001094286117162206
aorty.1798776001094292122154199214
Je2140692001093380
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klinickým273569200109426688139160202245292369
syndromem3123692001093580132184214265341388465
aorty3606692001094495126159205
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u21407200010950
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4,2519720001094766
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0,5–22950720001094767116165209
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na3465720001095096
jeden3589720001092269123170222
milion2140734001097699122144196249
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případů2815734001095284107160207260311
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stenózy.3488734001093669115168220259306323
Pacienti2140748001094892134157203255286308
s24767480010936
MAS25397480010973130177
mívají2744748001097598143188211233
jednostrannou3005748001092269122174225262294325370422473524576
nebo3608748001095198151203
oboustrannou21407620010951106160213251284316363416469522575
stenózu2745762001093770118171224265318
renální3092762001093079132178202255278
tepny,3400762001093178133187231248
což3677762001094293134
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průtok2977776001095181132162212255
krve3250776001094273120165
ledvinami3433776001092167119164186237281356378
DECLARATIONS:4068272008648871301662142563043393604124625014570272008514
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of445728600874066
originality:45372860087406888130150192230251271298337356
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in439341000851758
Helsinki,447441000854785104134152193228248264
Finland,47614100085355394113149190232249
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June511541000852667109147
1964,528541000853771110150166
with54744100085537297139
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amendments,443742100853493130169210269305345369398414
as486842100853462
well494842100855287105122
as508842100853362
with51674210085526993133
the53184210085236298
ICMJE543442100851759116143179
Recommendations406843200853977112153216278317359402439465483525568598
for46974320085226389
the481843200852466104
Conduct,495443200854283125168210245272290
Reporting,527543200853978121163189217236278321338
Editing,40684430085347491115132172212227
and430844300853373113
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Journals,406845400852666105129169204221249265
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2018,503745400853673107140156
including52134540085165689106145186203243283
patient55164540085407540684650085234076116140
consent422246500853270110138174214238
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interest44134790087196288126154192224251
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disclosures:51074790087416293126147188220261289327359378
None.406849000854686126162177
Funding/Support:406850300873777119162183225267291329371414457499526554574
Tento406851500853670112138179
článek42815150085335188131169206
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CSc.495676600874281114134
vladimir.mihal@fnol.cz40687780085345186126143203220243256316333372407424477499539579596612644676