580
PEDIATRIE341804001074588147168222260309330374
PRO736804001074591154
PRAXI911804001074692148201221
/11788040010732
Pediatr.1255804001074587137156196223250262
praxi.1537804001075077118158177193
2025;26(3):166-1701750804001074487128172185229272295338359373410450495524563599641
/24368040010732
www.pediatriepropraxi.cz46818040010765133201214264309359378418445472491535585612659709736777817836852893931
1661288020012657111170
PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
Staphylococcus34136001063163100134175212244283318357392425466498
aureus85536001063877113145185218
jako10883600106226197136
původce123936001063374112151191227259
novorozeneckých151336001064080118157193234265297338370405441480512553
infekcí20823600106155687119155188205
Staphylococcus3409300297122204334470604719780913101711501253135614891589
aureus19739300297133267356474608707
jako2729920029870195323457
původce32349200298144283409542684790914
novorozeneckých340118002981412773995326227598699951135125913671496162717311870
infekcí22591180029866204284410539642707
MUDr.3401580013793168245287310
Veronika6721580013770124166230294324384443
Pokorná1,11371580013764126185247289354411154115900803651
2,160515900803616431580013729
MUDr.16941580013793168245287310
Lenka20261580013756115180239298
Ryšková,23461580013765124171231293350408437
Ph.D.2,28051580013764128156235261306815900803654
3,313515900803631721580013729
MUDr.32231580013793168245287310
Tomáš35551580013760117211269317
Matějek,38941580013793152192250282340400431
Ph.D.1,43481580013764127156234260460115900803651
24665159008036
1Dětská3401740078333711740013373128165209260313
klinika,708174001335178103163188239293315
Fakultní10471740013353102152213238274334359
nemocnice14301740013361116207268317378402451504
Hradec19581740013372107160222277327
Králové2308174001336097150175235286340
2Lékařská3401890078333731890013352106158211246290341395
fakulta791189001333286136197222258311
Univerzity11261890013371131156208262298346372407462
Karlovy16111890013360114149174235286341
v19761890013353
Hradci20521890013372107160222271296
Králové2371189001336097150175235287340
3Ústav3402040078333732040013371113150203254
klinické650204001335178103164188237288341
mikrobiologie,10142040013392117168205265327353413439499561586641662
Fakultní16992040013354102153214239275335360
nemocnice20822040013361117208268318378403452505
Hradec26112040013371107160222277326
Králové2961204001335996149175235286340
Staphylococcus340254001214776126179232274297349391442484525576612
aureus9682540012152104136180233269
(S.125525400121281282254001214769
aureus)13662540012152105136181233269294
je1678254001212474
významným1770254001214899144199247330385431515
patogenem23022540012157106138192249299354405488
způsobujícím28082540012143100155194249306361385408452475558
komunitní33842540012147100184239294317350405428
i3402680012123
nozokomiální3802680012154108148201247300381404450473526548
infekce945268001212377105153199242289
u12512680012154
novorozenců,13212680012155109154207239292332381435479532552
zejména1890268001214290113194244298344
na22512680012155101
jednotkách2369268001212473128182236267313361404458
intenzivní2843268001212377108156210252274321376398
péče32582680012156105150197
se3472268001213988
podílí35762680012156111167189213235
na3402810012155103
vysoké460281001214899138193240288
incidenci766281001212378122145201251306351374
invazivních1157281001212478125173216239287343365410464
infekcí.1639281001212378107156203246269290
Kolonizace19462810012154108131186241264307356400449
kůže24132810012146101144193
a26242810012148
sliznic268928100121406386128183206250
tímto2957281001213356138171224
agens31992810012148103153209247
představuje34642810012156891381952342673163402950012148104128178
významný539295001214899144199247331386431
rizikový99229500121325699122169222269320
faktor,1333295001213079125161215248264
který1618295001214783132165215
zvyšuje1855295001214293144183238262312
riziko218829500121335699123169223
rozvoje2432295001213387129180234258308
infekce2761295001212379108158205249298
až3080295001214891
šestinásobně.3192295001214090130164187242290329384441497548567
Patogen3403080012154101134188246296352
vyvolává721308001214899151206230278325374
široké112430800121406396151198248
spektrum1400308001214097149196232265321405
onemocnění18333080012156112163247303348404455511534
od23963080012155113
lokalizovaných2537308001212480127177200224267322369418474520564620
kožních31853080012147102144200223268324
infekcí3537308001212480109159207251274
po3403220012156112
závažné469322001214392138186228283333
systémové819322001214087126159208291345392440
stavy1277322001213972121167217
(např.1511322001212880127183216231
sepse,1759322001213989146185234254
osteomyelitida,2030322001215594127176231313358407431453486508564612632
meningitida).26803220012183132187210265320343375398454501527545
Klinický3242322001215479101156178222268318
obraz35773220012155111144192234
se340335001214090
odvíjí4533350012154112160184209232
od7073350012155112
konkrétního8423350012147100156203237287320376399456511
typu1375335001213483141197
infekce,1594335001212379108158205249298318
u19343350012155
systémových2012335001213987127161210293349396446490545
může25803350012183138181231
být28333350012157103140
iniciálně2995335001212479102147169217241296346
nespecifický33643350012155106145202253298321351377422340349001214797
s4643490012140
rychlou530349001213384127182206261316
progresí873349001215790145201234284323346
do12463490012156111
život1384349001214366115169201
ohrožujícího16123490012155111143198240295319342387410467522
stavu.2161349001213973122169224245
Diagnostika2433349001216790138194250305344378401447497
spočívá2957349001213996152197220268317
v33013490012148
kombinaci33753490012147101185242265320368413436
klinického34036200121477295150173218264313369424
obrazu7853620012155112145193237292
s10983620012139
komplementárními11583620012147101184241265316399450505538587619675698781804
vyšetřeními.1983362001214899138189222255304360383466490510
Etiologické2514362001214982105160184239296319364410459
agens29943620012148104155210249
prokazujeme3264362001215790144192241284339363413497547
pomocí3403760012157113196252297320
mikrobiologického6823760012183107153187242299323378402457513537581628677732788
vyšetření,1491376001214899138189222255304360383403
pro1916376001215790144
které2082376001214783132165215
obvykle23183760012155112160210258283333
hraje2673376001215588136160210
zásadní2905376001214392131180237292315
roli3242376001213387111134
odběr33983760012155112169220252
hemokultur.367237600121551063403890012183138185240264297351384400
Léčba758389001214796142198247
je1022389001212575
komplexní11153890012146100183240264314361417440
a15723890012149
zahrnuje1638389001214393148180236290314364
kauzální2020389001214796150193242266321344
antimikrobiální23813890012148104136159242265311345399456480528551606629
terapii,3027389001213383115164220244267287
podpůrnou33323890012157112169226281313369424479
péči3404030012157108154176
a5384030012148
cílené60740300121456893143199250
řešení878403001213282122172228251
eventuálních1150403001215097147202235289338361416439484539
komplikací.17104030012147101184241265288335384429451472
Navzdory3404160012166115161207263319352402
pokroku7714160012157113160195249297353
v11524160012148
péči12294160012157108154177
zůstává1434416001214398138172221267316
S.1779416001214769
aureus18734160012152105137181234271
častým2172416001214594133167217302
nozokomiálním25024160012156111153208255309393417465488544567650
agens31814160012148105155211250
s34594160012140
potenciálem35284160012157113146195251340430001214568116140190274
vzniku643430001214893149173219275
závažných947430001214293139188232287333377433
následků.14084300012156104144167218275322378398
Prognózu1835430001215385140197253308350406
ovlivňuje22694300012155103127150199255310334384
zejména2682430001214393117201252308356
závažnost3067430001214393139188232287343382416
infekce3512430001212379108159206250299
a3404430012148
přítomnost416443001215790113146200284339394434467
komplikací.9114430012147101184241265288335384429452472
Klíčovou1411443001215479102147200247301357
preventivní1795443001215790140187237292325348396452475
strategií2298443001213973106154187236293316339
je2665443001212474
minimalizace27674430012184107162185268316340363405455500549
invazivních3344443001212378125173217240288345368412467
výkonů340457001214899146200256310
a6714570012149
včasné741457001214891140179234285
odstraňování10474570012155112151185217266321376423472527550
cizorodých1618457001214568111165198253310358401456
materiálů.20964570012183131164213246269317341395415
Klíčová340473001246190118163220272325
slova:686473001244371129181234260
Staphylococcus967473001214776126179233275298349392443486526578614
aureus,1599473001215210513718123427018684730012121
novorozenecká19104730012155110158212244299341391446497543589638
infekce,2569473001212479108158205249298318
nozokomiální29084730012156111152207254308392415463486541564
infekce,3494473001212378107157204248297317
multifokální3404870012183138162195218247302349398422477500
osteomyelitida,861487001215594128177233317363412436459492515571619640
fosfomycin.1523487001212984123153208292337381404459481
Staphylococcus340512001245186141199256305331388432489533577633676
aureus10345120012456112150201258300
as1354512001245396
a14715120012452
pathogen15445120012459113149209267326380439
in2003512001242887
neonatal21105120012458111170229282319372400
infections2530512001242887121174220259288346405448
Staphylococcus340529001214674123175227268290341382432473513563598
aureus9535290012151102133176228263
(S.123052900121287192
aureus)13375290012151102133176228263287
is1641529001212361
a17185290012148
significant1782529001213961116170192220246289336390422
pathogen22205290012156104135189243298347401
responsible2638529001213280119174228283320342398421470
for3124529001212983115
both32555290012156111143196
community-acquired3468529001214496178259313340542001215577109158188235279333387409441489545
and9025420012148102157
nosocomial10765420012155108147201245298380402449472
infections1565542001212377105154198233255309363401
in1983542001212377
neonates.20775420012155104158213260292340378399
It2493542001212355
contributes2565542001214497151183214237293347379427466
to3048542001213285
a31505420012148
high3214542001215577132186
incidence3417542001212377121143199248302346394
of340556001215584
invasive447556001212479125174213236284333
infections,803556001212479108158204239262317373412433
especially1259556001215090146197243266314337360408
in1690556001212379
intensive1792556001212379111160216255277326375
care2190556001214594126176
units.23895560012155111134167207229
Colonization26415560012158111135191246269312362394418472528
of3193556001215484
the3300556001213388138
skin3462556001213986111166
and36515560012148104160
mucous3405690012183138183237292331
membranes6965690012184134218275308356411462501
by12225690012157104
this1351569001213388111150
agent15265690012148104154210242
is1793569001212462
a18805690012149
major19545690012183131155210243
risk222256900121335695141
factor,2388569001213079123159213246262
increasing2675569001212378123156205254293315371427
the3127569001213388138
likelihood329056900121244794143167189245300355413
of3728569001215584
developing3405830012156107154203227283340363419475
an8365830012148103
infection960583001212479108158204239262317373
up13545830012155112
to1487583001213387
sixfold.1595583001214063110142197221277298
The3405960012149105155
pathogen5125960012156104136190245301350405
causes934596001214593146185234273
a12245960012148
wide1289596001217397152202
range1508596001213280135190240
of1765596001215483
diseases,1865596001215678117166214252302341361
from2243596001212962116199
localized2459596001212378122170193216258307363
skin2840596001213985109163
infections3021596001212377106155200235257311366404
to3443596001213286
severe3546596001213989136184216265
systemic340610001213985123156204285307350
conditions707610001214395149204226258280333387424
(e.g.,114861000121287392146166186
sepsis,1350610001213988143181203241261
osteomyelitis,1627610001215492124172226307351399422444475497535555
meningitis).21986100012182131185207260314337368390428451469
The26836100012149104152
clinical285261000121446688141163206253275
presentation3144610001215687135173222276307354386408461515
depends367561000121551043406230012156105158212249
on6006230012154107
the718623001213285133
specific862623001213993142185206234258300
type1174623001213280135183
of1369623001215381
infection,1461623001212375102150194227248301354373
and18456230012147100154
in2010623001212376
systemic2097623001213985122154201281303345
cases,2453623001214490127175213232
it2696623001212354
may27616230012182128171
initially294462300121227596127149194216237282
be32376230012156105
nonspecific33536230012154107160197251300343364391416458
with340637001217294126179
rapid534637001213279133156210
progression759637001215687140194225273311349370423477
to1251637001213284
a13506370012147
life-threatening141263700121234472121152184237268316362393441494516569623
state.2050637001213971118149196215
Diagnosis2280637001216588134188241294332353390
is2685637001212360
based27606370012156103140189244
on30186370012154108
a31416370012147
combination3203637001214495176231253307353384406459512
of3730637001215481
clinical34065000121446688141163206253276
symptoms632650001213985167222254306388425
and10736500012148101156
complementary1245650001214496177232255304385434488519566597646
examinations.1908650001214994141222244297344375397450504541562
The24866500012149103152
etiological2655650001214981103156179232287309352399422
agent30936500012147102150204235
is3345650001212360
identified3421650001212378126180211233261287335391
through340664001213286117170224278332
microbiological6886640012182104147179232287310363386439494517560607629
testing,1334664001213280118151173226281300
where16516640012172126175207255
blood1922664001215679133187242
culture2180664001214498120152205236284
collection2481664001214496119141190234268290343397
usually2895664001215491144191213235281
plays3192664001215679126170208
a34166640012148
key3480664001214693139
role.3635664001213285108157176
Treatment340677001215076125173205288339394426
is784677001212361
complex863677001214598181238261311358
and12396770012148103159
includes1416677001212378123146200257306346
causal1779677001214593148186235258
antimicrobial20556770012148103135158240263308340394451474522545
therapy,2618677001213387138170218275321337
supportive2972677001214094150207263295331354402451
care,3440677001214593125175195
and36526770012148103159
targeted340691001213382114170220254303360
management7226910012183131186234290341424475531563
of1306691001215584
potential14116910012157113146195251283306354378
complications.1810691001214598182239263286330379412435490545584605
Despite3407040012166117156212235268317
advances6747040012148104152200255299348387
in1079704001212378
care,1174704001214593125174194
S.1386704001214668
aureus14697040012152104136180232268
remains1754704001213382165212235290328
a21007040012148
common2165704001214598181264318373
nosocomial25567040012155110149203248302385408455478
agent30527040012147103153208240
with3310704001217396129183
the3511704001213388137
potential36667040012157112340718001213384140173197245269
to638718001213489
cause756718001214594150190241
serious1026718001214091125149205261301
consequences.13567180012145100156196247305361412469515564605627
The20117180012151108159
prognosis2199718001215892147205261317357380420
is2648718001212463
mainly27407180012185133157213237285
influenced3054718001212480110137192243300346396454
by35377180012158105
the3671718001213389141
severity340731001213990137186218242275324
of682731001215483
the783731001213388138
infection939731001212378107157202237260314370
and13277310012148103159
the1504731001213387137
presence1659731001215790139178229284329377
of2054731001215584
complications.2155731001214598181238262285329377410432487542581602
A27757310012161
key2853731001214796142
preventive3013731001215789139186235290322345393442
strategy3473731001213973105153186235291339
is340745001212362
minimizing4237450012184107162185268292335358413469
invasive913745001212479125174213236284333
procedures1268745001215689144190239296350383433472
and17617450012149104161
promptly1943745001215790144228285318341388
removing2352745001213383167222269293348404
foreign2777745001212984117167191247302
materials.31007450012184132164214246270318341380401
Key3407610012460111161
words:5177610012474130167226269294
Staphylococcus828761001214674124175227269290341383432474513563599
aureus,1441761001215110313317722826317037610012120
neonatal17407610012155104158213259291338361
infection,2118761001212377104153198232254308362382
nosocomial25177610012154108146200245297379401448470
infection,3004761001212377105154198232255308362382
multifocal34037610012182136158190212241294339386408
osteomyelitis,340775001215594128177233317362412436459492515554575
fosfomycin.936775001212984123153208292338381404460481
DECLARATIONS:4068257008648871301662142563043393604124625014570257008514
Declaration406827000874987120141179206244271291333375
of445727000874066
originality:45372700087406888130150192230251271298337356
The406828200853473109
manuscript418828200855891130168195227249266306329
is452828200851744
original45832820085386178117133172205222
and481628200853472112
has49392820085387299
not50502820085387699
been516128200853975110149
published532228200853977117134150177216251291
or406829300853862
submitted414529300852867108167184208234269310
elsewhere.44702930085355381117169209245269305320
Ethical406830600873764107127160198218
principles43003060087427090132165185228249287319
compliance:463330600873173134177197218256298330368387
The406831700853678116
authors420531700853475100142183208238
attest44643170085356087124153179
that466431700852465101126
their481131700852465103121146
study49783170085295595138173
was517331700855389118
approved531231700853577120145186221258301
by406832800854073
the41583280085236399
local42743280085175689124141
Ethical44323280085345898115147182199
Committee464832800854179139198215239265300337
and500232800853373113
is513232800851745
in519432800851656
compliance526732800853169129169187204239278311346
with40683390085537298140
human423633900854081143180221
studies44863390085285596139157195226
and474033900853577119
animal48883390085347695156193212
welfare512833900855391110133170196234
regulations53903390085236110414516420140683500085234080120148
of423535000853960
the43153500085236399
authors’44343500085347397136176200229244
institutions46983500085165684109126150189213231270310338
as505635000853462
well513835000855187104122
as527935000853462
with53613500085526993133
the55143500085236299
World406836100856099124142184
Medical427336100855795137155188224242
Association453536100854474104144178196231256273314355
Declaration491136100854785119136172196232257274315356
of528836100853961
Helsinki537036100854684102131149189224243
on406837200854082
Ethical418537200853561104123157195214
Principles44343720085386383125160179222242281311
for47803720085216389
Medical490437200855897141160194232251
Research519037200853978108147184210244287
ing551137200851759102
Human406838300854685145179219
Subjects430738300853474114132168201227256
adopted458338300853474114155179215256
by485838300854074
the49523830085236399
18th507138300853669514138400501437
WMA5198383008559116160
General537838300854582122158182217235
Assembly406839400854475105143204247266302
in439339400851758
Helsinki,447439400854785104134152193228248264
Finland,47613940085355394113149190232249
in503339400851758
June511539400852667109147
1964,528539400853771110150166
with54743940085537297139
subsequent406840500852867107136172213252288328352
amendments,443740500853493130169210269305345369398414
as486840500853462
well494840500855287105122
as508840500853362
with51674050085526993133
the53184050085236298
ICMJE543440500851759116143179
Recommendations406841600853977112153216278317359402439465483525568598
for46974160085226389
the481841600852466104
Conduct,495441600854283125168210245272290
Reporting,527541600853978121163189217236278321338
Editing,40684270085347491115132172212227
and430842700853373113
Publication443442700853776117134151183218242259298338
of478542700853859
Scholarly485742700853467106146163198221239273
Work514242700856097121155
in531042700851656
Medical537842700855693134151183218235
Journals,406843800852666105129169204221249265
updated435343800853980121155179215256
in462943800851656
December470543800854683116151211252289313
2018,503743800853673107140156
including52134380085165689106145186203243283
patient55164380085407540684490085234076116140
consent422244900853270110138174214238
where447544900855191127151187
appropriate.467744900853474115139178219243260295318354369
Conflict406846300874282124149171191223251
of433446300874065
interest44134630087196288126154192224251
and467846300873779122
financial48144630087244587125167200220258279
disclosures:51074630087416293126147188220261289327359378
None.406847400854686126162177
Funding/Support:406848800873777119162183225267291329371414457499526554574
None.406849900854686126162177
Cit.4068714008541588297
zkr:41807140085306489105
Pediatr.429971400863975117136173198224238
praxi.455271400864067103139158176
2025;26(3):166-170474371400863775112150167205243264301322338374409448473507541578
https://doi.org/10.36290/ped.2025.032406872500853962881291571721982194284725008641811004385725008514547811714345287250086387390130169206244283307347385427445485523560598615654691728
Článek40687360085415892132168202
přijat4285736008539638198132156
redakcí:445673600852359100134168199216231
8.470173600853652
4.476873600853651
2025483473600853672107144
Článek40687470085415892132168202
přijat4285747008539638198132156
k4456747008533
tisku:45047470085234068101141156
21.46757470085366981
5.477174700853651
2025483774700853672107143
MUDr.4068766008759108158186202
Veronika428476600874580108150192212251290
Pokorná458876600874081120161189231269
veronika.pokorna@fnhk.cz40687780085346993132172189222258273315355389427451491526578600641680714731763795