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Ph.D.30691580013764128156235261
Ústav3401740013371113150203254
preventivního617174001336298153204258319354379431493518580640
lékařství,1281174001332681132186221265301357382404
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fakulta2127174001333285136197222258311
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v26151740013353
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hepatitidy6332250012156106164213245268302325382429
u10912250012155
dětí11742250012157107141164
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skupinu2412225001213986142199222278333
onemocnění27732250012155111162246301347402453509532
vyvolaných3333225001214999151205229278333379423478
různými340239001213389132188234319343
hepatotropními7122390012156107164214246301334367422480536560644667
viry,1408239001214973106157173
které1610239001214783133166217
se1855239001214091
liší197523900121244786109
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přenosu,2587239001215891141197253293348369
klinickým298523900121477295151175220267318403
obrazem,34162390012156113147196240290374396
stejně340253001214176127153210263
jako633253001212575123179
rizikem842253001213459103128176227314
možného11862530012186143187245297355413
přechodu1629253001215893144192249306366423
do20822530012158115
chronického22272530012146104137194252276323371422480538
stadia.2795253001214076127186210260282
Velmi31072530012158106132218242
závažným3379253001214496144195240298345432
problémem340267001215790144202226276360410494
veřejného854267001214897130180204259309365420
zdraví1295267001214299131180226250
zejména1566267001214292116199250306354
u19402670012155
dětské20162670012156106140180227275
populace23122670012157113170225249297342391
je2723267001212474
hepatitida28182670012155106163212244267300323380428
A.3266267001216185
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tato3643267001213382114168
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platí,681295001215780127159182202
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dítěte.2985295001215578110159192240260
V32622950012155
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případech340309001215790113170219275326371426
může7853090012183138180230
dojít10343090012156111135158191
k12433090012147
fulminantní1308309001213085109192215270318374406461484
hepatitidě,18113090012155106163211244267300323380430450
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je2510309001212575
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s29513090012140
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úmrtností.33773090012155138171207262317356390413434
Nejúčinnější3403230012166117140195240263318373424447486509
metodou8693230012183134167221279334389
prevence1278323001215790140187236292337386
je1684323001212474
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očkování20793230012155100146200247296351374
dětí.24733230012156107140163184
Po26763230012154107
zavedení2803323001214292139188245295351374
účinné31973230012155100123178233284
vakcíny3500323001214997144187210266311
se340337001214090
incidence450337001212479124147204254310354404
infekce874337001212379107158205248297
ve1192337001214897
Spojených13093370012150106162186236292337381436
státech1766337001213973122155204249304
snížila2091337001213995118161184207255
o23673370012155
více2442337001214872117166
než26283370012155106149
9027983370012151103
%.29143370012179101
Nicméně3036337001216589133217267323373
v34303370012148
současnosti34983370012140951501952442833403510012155110149182205
počet5623510012157112157205238
případů818351001215689112168216272326
opět11623510012155111162195
stoupá1374351001213973126181237285
v16773510012148
důsledku17423510012156110149172221278324379
rozsáhlých2139351001213286127168217271294341385439
ohnisek25963510012154109164187225275322
nákazy29353510012155103149198241290
v32433510012147
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populaci.3403650012157113170225249297342365385
Virové750365001215580112167214263
hepatitidy10383650012155106163211244267300323380427
u14903650012155
dětí15693650012156107140163
představují1756365001215790140197236270319365421445468
stále2248365001214074123146196
aktuální2469365001214895130185233257312335
téma2828365001213383166214
pediatrické30673650012157108165188236269301325369416465
praxe.3556365001215790139186235255
Očkování,3403790012170116163217265315371394415
edukace7843790012151109165212262308358
a11703790012149
mezioborová12483790012184136180204260318375408464512561
spolupráce1838379001214097154179234292325375420470
zůstávají2337379001214399139173223270320344367
základními2733379001214494142167216274330353438462
pilíři3223379001215882106130165189
efektivní3441379001215181132180217240289346370
péče3403930012157108154203
o5643930012155
tyto640393001213383119173
pacienty.8343930012157106151174224280312362378
Klíčová340409001246088115159215266318
slova:674409001244370127178229254
dětská9454100012156105137176222270
populace,12314100012157111167221244291334382401
virová1649410001214770102155201248
hepatitida,19144100012155104160207239261293316371418438
očkování,2369410001215498143196242289343365385
hepatitida27714100012154103159207238261293315370417
A,3205410001216082
hepatitida33044100012154104159207239261293315370417
B,3738410001215373
hepatitida3404240012155106163212244267300323380428
C,789424001215881
hepatitida8914240012155106163212244267300323380428
D,1340424001216785
hepatitida14464240012155106163212244267300323380428
E,1895424001214970
výživa.1986424001214899144167216264285
Viral340451001246492130183211
hepatitis5714510012458111172225262290327356399
with9914510012476104141200
emphasis12114510012453140200260313356384428
on16594510012458117
hepatitis17964510012458111172225262290327356399
A22164510012465
in2301451001242887
the2408451001243796149
paediatric25784510012459113166226254307344383410456
population30544510012460118178237265319355384442500
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hepatitis5514690012156106163212245268301324363
in940469001212479
children1046469001214499122146202235285340
represents1413469001213382140173222262312368400441
a18804690012149
heterogeneous19554690012156106140189222276333384439490545601640
group2621469001215689143199255
of2903469001215584
diseases3014469001215679118169217256306346
caused3386469001214594148187238295
by37084690012157103
different340483001215680109141192225274330362
hepatotropic7254830012155106163212244298331363418475499543
viruses,1291483001214872104160199249289310
which16234830012174130153198253
differ1898483001215680109142192225
in2145483001212379
the2246483001213388139
mode24074830012184139196247
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transmission,2783483001213365114169208291314353392415470525546
clinical335248300121446891146169213262285
picture,3660483001215781125340497001213388121170190
as549497001214887
well6554970012174123147170
as844497001214887
the950497001213388139
risk110849700121325695141
of1268497001215584
possible13714970012157113152191214270295345
transition1735497001213365114169208231264287342398
to2151497001213387
the2257497001213388139
chronic24154970012145100132187242265310
stage.2744497001213973122178228249
Hepatitis30114970012166116173222255278311334373
A34024970012162
is3482497001212463
a35634970012149
very3630497001214998131181
serious340511001214091124148203259298
public6675110012157113170195218263
health9585110012156107156179213268
problem,1255511001215790145203227278362383
particularly16675110012157106139175198244299322371404428475
in2171511001212479
the2279511001213389140
paediatric24475110012157107157215238287319352376421
population.28975110012157113171227251299332355411467488
Although3414511001216185118174229285342397
this340525001213389112152
infection520525001212480109160206242265321377
does9265250012157112164204
not11585250012156112145
cause1332525001214594149189240
chronic16015250012145100133188245268313
liver194352500121244796146179
disease,2151525001215680119170219258309330
it2509525001212457
is2595525001212463
associated2687525001214888127183229252301334383441
with3157525001217498132188
significant3373525001214063120176199229256301350406438
morbidity.3405390012183139172229252309332365415431
In793539001212480
general,8955390012155106161212245293317337
the1254539001213388139
severity1415539001214090138187220243276326
of1763539001215584
the1869539001213388139
disease2030539001215679118168217256306
is2358539001212362
inversely2442539001212479125174207248298322369
proportional2833539001215790145202258291327350405460508532
to3387539001213387
the3496539001213388139
age36575390012148104154
of340553001215584
the447553001213389139
child.6095530012145100123147203224
In856553001212480
rare959553001213381114164
cases,1146553001214593133183222244
fulminant1413553001212985108191215270318373406
hepatitis18425530012155106163212244267300323362
may22285530012183131177
occur24285530012155101144199232
and26835530012148103160
is2866553001212463
associated2952553001214887126182227250298330380437
with3412553001217498131186
high3621553001215679135190
mortality.3405670012182136168203251273296328376392
Universal7495670012164117140187235267306354376
vaccination1142567001214795139181203257304336358412466
of1625567001215482
children1724567001214498120143198229278332
is2073567001212361
the2151567001213286136
most23035670012182136175208
effective2527567001215079110159204238260308356
method28995670012182132164218272328
of3244567001215482
prevention.3343567001215688137183231285317339393447468
Following3405810012149103127150205278301357413
the777581001213389139
introduction941581001212378111143198255310355390413468524
of1489581001215584
an15985810012148103
effective1726581001215080112162208243266315364
vaccine,2115581001214896141185207263313333
the2473581001213388138
incidence2636581001212379124147203253309354403
of3064581001215584
infection3172581001212479108158204239262317373
in3569581001212479
the3672581001213489139
United3405950012164119142174223280
States637595001214980129161210249
has9035950012156103142
decreased10625950012156106151184233281319369426
by15055950012157103
more16265950012183137170219
than1863595001213387135190
9020705950012151103
%.21855950012179101
However,23045950012164120192241288337369385
the2707595001213287137
number28625950012155109192248299331
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cases3311595001214593132182221
is3550595001212361
now36295950012155110182
on3406090012154109
the466609001213387136
rise61960900121335693143
again7796090012148103150172226
due10226090012156110159
to1198609001213386
large1301609001212370102157206
outbreaks15246090012154109141196229278325370412
in1953609001212377
the2047609001213387137
unvaccinated22016090012154108154201245288310365412443492548
population.27666090012156111167222244291323346400454475
Viral3258609001215579110158181
hepatitis34566090012155104160208240262294317355
in340623001212378
children4366230012145100123146203235285340
is794623001212462
an8746230012148104
ongoing9966230012154110166221244299355
topic1369623001213387144168213
in1599623001212479
pediatric16966230012157108165188236268301324369
practice.2083623001215689138182218241285334354
Vaccination,24556230012156101146190212268315348371426481502
education29756230012150107162206255287310365421
and34146230012148103160
interdisciplinary3591623001212479111160193340637001215680118163186243267290345393426476
collaboration837637001214599123146194251307339388421444499554
remain1412637001213383167215238293
the1726637001213388139
mainstays18866370012183132155210249282331377417
of2324637001215584
effective2429637001215080112163208243267315364
care2814637001214594126176
for3011637001212984117
these3149637001213389139179229
patients.33996370012157106138161212267300340361
Key3406530012461111162
words:5196530012475131169228271296
child833654001214499121144199
population,10506540012156111167222245292324346400455475
viral1543654001214771102150173
hepatitis,17336540012155105161209241263296318356377
vaccination,2127654001214896140182205259306338361415470490
hepatitis26346540012155105161209241263296318356
A,3007654001216183
hepatitis31086540012155104160208240263295318356
B,3481654001215474
hepatitis3572654001215510516120934066800121335689112151
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Dle480720001096286135
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zdravotnické1014720001094094126173218270303356380423468516
organizace1571720001095184137184237260302350394441
(WHO)3407340010926107169235260
je629734001092270
nově7277340010952104148195
ročně950734001093182125177225
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a10707620010943
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jednoho1377762001092268120170220271321
milionu1723762001097597118139189240289
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C.793776001095272
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503718720001094793
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dat2586748001095092120
z27217480010938
USA,2774748001095799152172
Izraele,296174800109215987130174195240257
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of445724100874066
originality:45372410087406888130150192230251271298337356
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compliance:463327700873173134177197218256298330368387
The406828800853678116
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attest44642880085356087124153179
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