Pediatr. praxi. 2026;27(3):148-151 | DOI: 10.36290/ped.2026.024

Neutropenia - a practical guide

MUDr. Veronika Fiamoli, Ph.D.
Oddělení dětské hematologie a biochemie Fakultní nemocnice Brno

Neutropenia is one of the most common hematological findings in children. In the pediatric population, immune-mediated neutropenias predominate, which are transient with variable neutrophil levels, mostly without severe clinical manifestations and may remain under the care of a pediatrician. The most common units of acquired neutropenia include autoimmune neutropenia, parainfectious neutropenia, neonatal neutropenia, and drug-induced neutropenia and neutropenia due to nutritional deficiencies. In contrast, congenital neutropenias, which manifest during the first months of life, are persistent and are accompanied by profound neutropenia with severe infections and belong under the care of a hematological center.

Keywords: acquired neutropenia, hereditary neutropenia, autoimmune neutropenia, children.

Accepted: June 22, 2026; Published: July 1, 2026  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Fiamoli V. Neutropenia - a practical guide. Pediatr. praxi. 2026;27(3):148-151. doi: 10.36290/ped.2026.024.
Download citation

References

  1. Villarreal M. Neutropenia: A brief review Pediatr Ann. 2023;52(6):e238-e241. Go to original source... Go to PubMed...
  2. Boxer LA. How to approach neutropenia. Hematology Am Soc Hematol educ program. 2012;2012:174-182. Go to original source...
  3. Suková M. Leukopenie, In: Šrámková L, Starý J, Pospíšilová D. Dětská hematologie. Praha: Grada publishing. 2024:169-183.
  4. Čermák J. Granulocytopenie. Vnitř. lék. 2018:64(5):520-525. Go to original source...
  5. Hauck F, Klein C. Pathogenic mechanisms and clinical implications of congenital neutropenia syndromes. Curr Opin Allergy Clin Immunol. 2013;13:596-606. Go to original source... Go to PubMed...
  6. Walkovich K, Boxer LA. How to approach neutropenia in childhood. Pediatr rev. 2013;34:173-84. Go to original source... Go to PubMed...
  7. Lanzkowsky P. Manual of pediatric hematology and oncology. 5th ed. New York: Churcjill Livingstone Inc. 2011:275-95.
  8. Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis. 2011;52(4):56-93. Go to original source... Go to PubMed...
  9. Capsoni F, Sarzi-Puttini P, Zanella A. primary and secondary autoimmune neutropenia. Arthritis Res. Ther 2005;7:208-214. Go to original source... Go to PubMed...
  10. Mitchell C. Management of isolated neutropenia in paediatrics.In: ashfordstpeters.net [online]. [cit 18-9-2024]. Available from: https://ashfordstpeters.net/Guidelines_Paediatrics/Isolated-Neutropenia-Sep-2024.pdf .
  11. Greenberg PL, Mara B, Steed S, et al. The chronic idiopathic neutropenic syndrome: correlation of clinical features with in vitro parametres of granulocytopoesis. Blood. 1980;55:915. Go to original source...
  12. Boxer I, Dale DC. Neutropenia causes and consequences. Semin Hematol. 2002;39:75-81. Go to original source...
  13. Schmutz N, Henry E, Jopling J, et al. Expected ranges for blood neutrophils concentrations of neonates: the Manroe and Montzinho charts revisited. J perinatol. 2008;28:275-281. Go to original source...
  14. Eagle WD, Rosenfeld CR. Neutropenia in high risk neonates. J pediatr. 1084;105:982-986. Go to original source...
  15. James RM, kinsey SE. The investigation and management of chronic neutropenia in children. Arch dis child. 2006;91:852-958. Go to original source... Go to PubMed...
  16. Pachlopnik Schmidt JM, Kuehni CF, Srrippoli MP, et al. Maternal tobacco smoking and decreased leukocytes, including dentdritic cells, in neonates. Pediatr res. 2007;61:462-466. Go to original source... Go to PubMed...
  17. Andrés E, Zimmer J, Mecili M, et al. Clinical presentation and management of drug-induced agranulocytosis. Expert Rev Hematol. 2011;4(2):143-151. Go to original source... Go to PubMed...
  18. Andres E, Villalba NL, Zufiqar AA, et al. State of art of idiosyncratic drug-induced neutropenia or agranulocytosis, with a focus on biotherapies. J Clin Med. 2019;8:135. Go to original source... Go to PubMed...
  19. Newburger PE, Dále DC. Evaluation and management of patients with isolated neutropenia. Semin hematol. 2013;50:198-206. Go to original source... Go to PubMed...




Pediatrics for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.