Pediatr. pro Praxi, 2006; 1: 35-38

Thrombocytosis in children

prof. MUDr. Vladimír Mihál CSc, doc. MUDr. Dagmar Pospíšilová Ph.D, MUDr. Zbyněk Novák
Dětská klinika LF UP a FN Olomouc

Thrombocytosis is frequently found as an incidental laboratory abnormality during an examination of complete blood count that was indicated because of another medical nonassociated reason. When it is found, it can cause a serious diagnostic uncertainty. Thrombocytosis is either a reactive process (secondary thrombocytosis) or less frequently it is caused by a clonal (myeloproliferative) disorder of bone marrow. It is usually extremely difficult to differentiate primary thrombocytosis from reactive one on basis of clinical and laboratory finding. Authors present current opinion on pathogenesis and clinical consideration of primary and secondary thrombocytosis in children.

Keywords: primary thrombocytosis, essential thrombocytosis, secondary thrombocytosis, reactive thrombocytosis, thrombocythemie, thrombopoetine, megacaryopoesis, bleeding and thrombotic complications

Published: January 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Mihál V, Pospíšilová D, Novák Z. Thrombocytosis in children. Pediatr. praxi. 2006;7(1):35-38.
Download citation

References

  1. Akan H, Güven N, et al. Thrombopoietic cytokines in patients with iron deficiency anemia with or without thrombocytosis. Acta Haematol 2000; 103: 152-156. Go to original source... Go to PubMed...
  2. Blatt J, Penchansky L, Horn M. Thrombocytosis as a presenting feature of acute lymphoblastic leukemia in childhood. Am J Hematol 1989; 31: 46-49. Go to original source... Go to PubMed...
  3. Borgna PC, Carnelli V, Caruso V, et al. Thromboembolic events in beta thalassemia major: an Italian multicenter study. Acta Haematol 1988; 99: 76-79. Go to original source... Go to PubMed...
  4. Dame Ch, Sutor AH. Primary and secundary thrombocytosis in childhood. Br J Haematol 2005; 129: 165-177. Go to original source... Go to PubMed...
  5. Diagne I, Sall MG, Camara B, et al. Major thrombocytosis associated with severe anemia in children. Diagnosis of 9 cases. Dakar Med 2002; 47: 52-56. Go to PubMed...
  6. Dodig S, Raos M, Kovac K, et al. Thrombopoietin and interleukin-6 in children with pneumonia-associated thrombocytosis. Arch Med Research 2005; 36: 124-128. Go to original source... Go to PubMed...
  7. Espanol I, Hernandez A, Cortes M, et al. Patients with thrombocytosis have normal or slightly elevated thrombopoietin. Haematologica 1999; 84: 312-316. Go to PubMed...
  8. Falanga A, Marchetti M, Evangelista V, et al. Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera. Blood 2000; 96: 4261-4266. Go to original source...
  9. Garoufi A, Voutsioti K, Tsapra H, et al. Reactive thrombocytosis in children with upper urinary tract infections. Acta Paediatr 2001; 90: 448-449. Go to original source... Go to PubMed...
  10. Harrison CN, Gale RE, Machin SJ, Linch DC. A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications. Blood 1999; 93: 417-424. Go to original source...
  11. Hasle H. Incidence of essential thrombocythaemia in children. Br J Haematol 2000; 110: 751. Go to original source... Go to PubMed...
  12. Hsu HC, Tsai WH, Jiang ML, et al. Circulating levels of thrombopoeitic and inflamatory cytokines in patients with clonal and reactive thrombocytosis. J Lab Clin Med 1999; 134: 392-397. Go to original source... Go to PubMed...
  13. Kilpi T, Anttila M, Kallio MJ, et al. Thrombocytosis and thrombocytopenia in childhood bacterial meningitis. Pediatr Infect Dis J 1992; 11: 456-460. Go to original source... Go to PubMed...
  14. Kiraz S, Ertenli I, Öztürk MA, et al. Bloodstream thrombopoietin in rheumatoid arthritis with thrombocytosis. Clin Rheumatol 2002; 21: 453-456. Go to original source... Go to PubMed...
  15. Koksal N, Hacimustafaoglu M, Bagci S, Celebi S. Meropenem in neonatal severe infection due to multiresistant gram-negative bacteria. Ind J Pediatr 2001; 68: 15-19. Go to original source... Go to PubMed...
  16. Komura E, Matsumura T, Kato T, et al. Thrombopoietin in patients with hepatoblastoma. Stem Cells 1998; 16:329-333. Go to original source... Go to PubMed...
  17. Michiels JJ. Aspirin and platelt-lowering agents for the prevention of vascular complications in essential thrombocythemia. Clin Appl Thrombosis/Hemostasis 1999; 5: 247-251. Go to original source... Go to PubMed...
  18. Nakayama H, Ihara K, Hikino S, et al. Thrombocytosis in preterm infants: a possibile involvement of thrombopoietin receptor gene expresion. J Mol Med 2005; 83: 316-320. Go to original source... Go to PubMed...
  19. O´Śhea J, Sherlock M, Philip R. Thrombocytosis in childhood. Acta Haematol 2005; 113: 212. Go to original source... Go to PubMed...
  20. Rinder HM, Schuster JE, Rinder CS, et al. Correlation of thrombosis with increased platelet turnover in thrombocytosis. Blood 1998; 91: 1288-1294. Go to original source...
  21. Schafer AI. Thrombocytosis. N Engl J Med 2004; 350: 1211-1219. Go to original source... Go to PubMed...
  22. Uppenkamp M, Makarova E, Petrasch S, Brittinger G. Thrombopoietin serum concentration in patients with reactive and myeloproliferative thrombocytosis. Ann Hematol 1998; 77: 217-223. Go to original source... Go to PubMed...
  23. Valade N, Decailliot F, Rébufat Y, et al. Thrombocytosis after trauma: incidence, aetiology, and clinical significance. Br J Anaesth 2005; 94: 18-23. Go to original source... Go to PubMed...




Pediatrics for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.