Pediatr. praxi. 2012;13(4):252-254
Transient hyperphosphatasemia
- 1 Pediatrická klinika LF MU a FN Brno
- 2 Klinika dětské radiologie LF MU a FN Brno
Transient hyperphosphatasemia (TH) of infancy and childhood is a temporary and isolated increase of serum alkaline phosphatase (ALP-s)
activity occurring without obvious cause usually during the first five years of life. The diagnosis of TH is established after finding of a transient
but marked ALP-s elevation in the absence of clinical or laboratory findings of bone or liver disease. ALP-s returns to normal in a few
months. TH has not been found to be life-threatening and is classified as a benign phenomenon. We report a clinical case of a toddler with
TH and a literature review. This condition should be recognized by pediatricians in order not to put patiens throught lengthy, expensive
and unnecessary investigation.
Keywords: alkaline phosphatase, transient hyperphosphatasemia, childhood
Published: August 24, 2012 Show citation
References
- Bach U. Das Verhalten der alkalischen Serumphosphatase bei Frühgeborenen, Rachitikem and Spasmophilen. Z Kinderheilk 1954; 74: 593-609.
Go to original source... - Kraut JR, Metrick M, Maxwell NR, et al. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and review of the literature. Am J Dis Child 1985; 139: 736-740. Go to original source...
Go to PubMed... - Kutilek S, Bayer M, Markova D. Prospective follow-up of children with transient hyperphosphatasemia. Clin Pediatr 1997; 36: 491-492. Go to original source... Go to PubMed...
- Behulova D, Bzduch V, Holesova D, et al. Transient hyperphosphatasemia of infancy and childhood: study of 194 cases. Clin Chem 2000; 46: 1868-1869. Go to original source...
- Kutilek S, Bayer M. Transient hyperphosphatasemia of infancy and early childhood - clinical and laboratory data of 52 patients. J Paediatr Child Health 2003; 39: 157. Go to original source... Go to PubMed...
- Kolský A, Kutílek Š. Tranzitorní hyperfosfatazémie u chlapce s ADHD. Pediatrie pro praxi 2002; 3: 245-246.
- Eboriadou M, Skouli G, Panagopoulou P, et al. Acute laryngotracheobronchitis and associated transient hyperphosphatasemia: a new case of transient hyperphosphatasemia in early childhood. J Paediatr Child Health 2006; 42: 149-150. Go to original source... Go to PubMed...
- Suzuki M, Okazaki T, Nagai T, et al. Viral infection of infants and children with benign transient hyperphosphatasemia. FEMS Immunol Med Microbiol 2002; 33: 215-218. Go to original source... Go to PubMed...
- Huh SY, Feldman HA, Cox JE, et al. Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics 2009; 124: 703-709. Go to original source... Go to PubMed...
- Kutílek S, Skálová S, Vethamuthu J, et al. Transient hyperphosphatasemia in pediatric renal transplant patients - is there a need for concern and when? Pediatr Transplant 2012; 16: E5-9. Go to original source... Go to PubMed...
- Teitelbaum JE, Laskowski A, Barrows FP. Benign transient hyperphosphatasemia in infants and children: a prospective cohort. J Pediatr Endocrinol Metab 2011; 24: 351-353. Go to original source... Go to PubMed...