Pediatr. praxi. 2013;14(3):189-191

Arterial thrombosis in 10-year old girl

MUDr.Barbora Králiková1, MUDr.Bohumír Blažek1, MUDr.Tomáš Pískovský1, doc.MUDr.Michal Hladík, Ph.D.1, MUDr.Václav Procházka, Ph.D.2, MUDr.Daniel Czerný2, doc.MUDr.Jaroslav Horáček, CSc.3
1 Lékařská fakulta Ostravské univerzity a Fakultní nemocnice Ostrava, Klinika dětského lékařství
2 Lékařská fakulta Ostravské univerzity a Fakultní nemocnice Ostrava, Ústav radiodiagnostický
3 Lékařská fakulta Ostravské univerzity a Fakultní nemocnice Ostrava, Ústav patologie

Authors present rare case of extensive arterial thrombosis in 10 years old girl. Thrombotic occlusion of all tibial arteries did not respond to

any of antithrombotic and thrombolytic therapy and due to critical ischemia and related complications called for amputation of lower

limb below the knee within 10 days after admission to the hospital. Extensive investigation revealed antiphospholipid syndrome with

positivity of anti ds-DNA, anti cardiolipin and anti Beta-2 Glycoprotein-I antibodies as a reason for acute fulminant limb thretaning thrombotic

event on the background of incipient systemic lupus erythematosus.

Keywords: arterial trombosis, antiphospholipid syndrome, amputation, hyperbaric therapy

Published: July 15, 2013  Show citation

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Králiková B, Blažek B, Pískovský T, Hladík M, Procházka V, Czerný D, Horáček J. Arterial thrombosis in 10-year old girl. Pediatr. praxi. 2013;14(3):189-191.
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    References

    1. Tan EM, Cohen AS, Fries JF, et al. The 1 982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-1277. Go to original source... Go to PubMed...
    2. Levine BN. The antiphospolipid syndrome. N Engl. J Med 2002; 346: 752-763. Go to original source... Go to PubMed...
    3. Viard JP, Amoura Z, Bach JF. Anti-beta 2 glycoprotein I antibodies in systemic lupus erythematosus: a marker of thrombosis associated with a circulating anticoagulant]. (in French). C. R. Acad. Sci. III, Sci. 1991; 313(13): 607-612.
    4. Erkan D. Lupus and trombosis. The Journal of Rheumatology 2006; 33: 1715-1717. Go to PubMed...

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