Pediatr. praxi. 2021;22(1):59-61 | DOI: 10.36290/ped.2021.010

Macro-AST as a cause of isolated increase of aspartate aminotransferase in an asymptomatic patient

MUDr. Markéta Veverková¹, MUDr. Jakub Pecl¹, MUDr. Tereza Pinkasová¹, MUDr. Zdeňka Čermáková, Ph.D.^{2, 3}, MUDr. Petr Jabandžiev, Ph.D.^{1, 4}

¹ Pediatrická klinika Fakultní nemocnice Brno a Lékařské fakulty Masarykovy univerzity, Brno

² Katedra laboratorních metod, Lékařská fakulta Masarykovy university, Brno

³ Oddělení laboratorní medicíny, Masarykův onkologický ústav, Brno

⁴ Středoevropský technologický institut - CEITEC, Brno

The macroenzyme of aspartate aminotransferase (macro-AST) is one of the causes of the isolated increase in serum aspartate aminotransferase (AST). We present a case report of a well-thriving girl with an accidentally detected persistent isolated AST elevation. A detailed laboratory analysis revealed this was due to an elevation of serum AST based on circulating macro-AST without the presence of another organic disease.

Keywords: aspartate aminotransferase, macro‑AST, macroenzyme.

Published: March 25, 2021  Show citation