Pediatr. praxi. 2021;22(6):399-401 | DOI: 10.36290/ped.2021.086

Maladaptive behavioral disorders in children caused by anaesthesia

MUDr. Zuzana Adamcová Petríková1, prof. MUDr. Beata Drobná Sániová, PhD.2, MUDr. Žofia Klimová1
1 II. klinika pediatrickej anestéziológie a intenzívnej medicíny, Detská fakultná nemocnica s poliklinikou Banská Bystrica, Univerzita Komenského v Bratislave, Jesseniova lekárska fakulta v Martine
2 Klinika anestéziológie a intenzívnej medicíny, Univerzitná nemocnica Martin, Univerzita Komenského v Bratislave, Jesseniova lekárska fakulta v Martine

Millions of paediatric patients per year, are undergoing the operations, all over the world. The most of these patients suffer from the preoperative anxiety, which intensity corelates with the development of maladaptive behavioral changes after the anesthesia. The influence of anesthetics to developing brain were omitted for a long time. But it has been shown that the general anaesthesia should influence cognitive functions for longer period. Even that it should have an impact to development on immature brain cognitive functions and should cause their deterioration at the adults.

Keywords: neurotoxicity of anesthetics, maladaptive behavioral disorders, post-anesthesia behavioral children changes, paediatric anesthesiology.

Published: November 24, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Adamcová Petríková Z, Sániová BD, Klimová Ž. Maladaptive behavioral disorders in children caused by anaesthesia. Pediatr. praxi. 2021;22(6):399-401. doi: 10.36290/ped.2021.086.
Download citation

References

  1. Mason KP. Paediatric emergence delirium: a comprehensive review and interpretation of the literature. British Journal of Anaesthesia 2017; 118(3): 335-343. Go to original source... Go to PubMed...
  2. Cvachovec K. Poruchy kognitívnych funkcií po anestézii 2014. Jsou anestetika toxická? Praha: 2015: 39-42. Dostupné z: https://www.medvik.cz/bmc/link.do?id=bmc16018508.
  3. Smessaert A, Schehr CA. Observations in immediate postanesthesia period. II. Mode of recovery. British journal of anesthesia 1960; 32: 181-185. Go to original source... Go to PubMed...
  4. Berghams J. The influence of preoperative emotional and behavioral function of children on postoperative behaviour: Child Behaviour Checklist Anesthesia Emergence Delirium [online]. Dostupné z: https:// www.ncbi.nlm.nih.gov/pubmed/24861721,2019.
  5. Jevtovic-Todorovic V, et al. Early exposure to common agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. Journal of Science 2003; 23(3): 876-882. Go to original source... Go to PubMed...
  6. Voepel-Lewis T, Malviya S. A prospective cohort study of emergence agitation in the pediatric postanesthesia care unit. Anesthesia & analgesia 2003; 96(6): 1625-1630.Další literatura u autorky a na www.pediatriepropraxi.cz Go to original source... Go to PubMed...
  7. Malarbi S, Stragatt R. Characterizing the behavior of children emerging with delirium from general anesthesia. Pediatric Anesthesia 2011; 21: 942-950. Go to original source... Go to PubMed...
  8. Clausen NG, Kähler S. Systemic review of the neurocognitive outcomes used in studies of paediatric anaesthesia neurotoxicity. British Journal of Anaesthesia 2018; 120(6): 1255-1273. Go to original source... Go to PubMed...
  9. Kain ZN. An Innovative tailored Intervention for Improving Children´s Postoperative Recovery (WebTIPS). Clinical Trials, 2018. Dostupné z: https://clinicaltrials.gov/ct2/show/NCT03730259.
  10. Kamat PP, Kudchadkar SR. Sedative and anesthetic neurotoxicity in infants and young children: Not just an operating room concern. The Journal of Pediatrics 2019; 204: 285-290. Go to original source... Go to PubMed...
  11. Deshui Y, Linji L. Neonatal anesthetic neurotoxicity: Insight into molecular mechanism of long-term neurocognitive deficits. Biomedicine and Pharmacotherapy 2017; 87: 196-199. Go to original source... Go to PubMed...
  12. O´ Leary JD, Warner DO. What do recent human studies tell us about the association between anaesthesia in young children and neurodevelopmental outcomes? British Journal of Anaesthesia 2017; 119(3): 458-464. Go to original source... Go to PubMed...
  13. Andropoulos DB, Stayer S. Anaesthesia for Congenital Heart Disease. Boston: Wiley 2015. Go to original source...
  14. Aranha PR, Sams LM. Impact of multimodal preoperative preparation program on children undergoing surgery. Arch Med health Sci 2017; 5: 208-214. Go to original source...
  15. Seiden SC, McMullan S. Tablet-based interactive distraction (TBID) vs oral midazolam to minimize perioperative anxiety in pediatric patients: a noninferiority randomized trial. Pediatric anesthesia 2014; 24: 1217-1223. Go to original source... Go to PubMed...
  16. Varughese AM, Hagerman N. A comparison of inhalational inductions for children in the operating room vs induction room. Pediatric anesthesia 2012; 22: 327-33419. Go to original source... Go to PubMed...
  17. Sanchez G, Carmen M. Reduction of preoperative anxiety in children using non- pharmacological measures. Nursing and care. 2015; S1: 004. doi: 10.4172/2167-1168.S1-004. Dostupné z: https://www.hilarispublisher.com/open-access/reduction-of-preoperative-anxiety-in-children-using-nonpharmacological-measures-2167-1168-S1-004.pdf. Go to original source...
  18. Tan Y, Shi Y. μ-Opioid agonists for preventing emergence agitation under sevoflurane anesthesia in children: a meta-analysis of randomized control trials. Pediatric anesthesia 2016; 26: 139-150. Go to original source... Go to PubMed...
  19. Jevtovic-Todorovic V, et al. Anesthesia induced developmental neurodegeneration: the role of neuronal organelles. Frontiers in neurology 2012; 3: 141. Go to original source... Go to PubMed...
  20. Wright KD, Stewart SH. Prevention and Intervention Strategies to Alleviate Preoperative anxiety in Children. Behavior Modification 2007; 31(1): 52-79. Go to original source... Go to PubMed...




Pediatrics for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.