Pediatr. praxi. 2025;26(1):24-26 | DOI: 10.36290/ped.2025.005
Transient hypogamaglobulinemia of infancy
- 1 Dětská klinika, Fakultní nemocnice Plzeň, Univerzita Karlova, Lékařská fakulta v Plzni
- 2 Oddělení revmatologie dětí a dospělých, Fakultní nemocnice Motol, Praha
- 3 Ústav imunologie a alergologie, Fakultní nemocnice Plzeň, Univerzita Karlova, Lékařská fakulta v Plzni
Transient hypogammaglobulinemia is a relatively common primary antibody immunodeficiency in infants and toddlers with a wide clinical picture. The pathophysiological basis is a delayed onset of the production of own immunoglobulins, resulting in a temporary decrease in serum IgG concentration in the infant. THI usually resolves spontaneously between the ages of 2 and 6 years. In the laboratory, a reduced serum IgG concentration (possibly also IgA and IgM) dominates with a normal representation of B-lymphocytes. In the differential diagnosis, we also consider other immunodeficiencies. Interdisciplinary cooperation is very important.
Keywords: THI, etiopathogenesis, clinical evaluation, differential diagnosis, treatment.
Accepted: March 6, 2025; Published: March 19, 2025 Show citation
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