Pediatr. praxi. 2012;13(2):126-129

Ewing sarcoma - a rare cause of joint and bone pain

prof.MUDr.Vladimír Mihál, CSc.1, doc.MUDr.Dagmar Pospíšilová, Ph.D.1, MUDr.Zbyněk Novák1, MUDr.Barbora Ludíková1, MUDr.Jana Mathonová2, prof.RNDr.Mgr.Marie Jarošová, CSc.3, MUDr.Tomáš Tichý, Ph.D.4, MUDr.Kamila Michálková5
1 Dětská klinika LF UP a FN v Olomouci
2 Kroměřížská nemocnice, Dětské oddělení
3 Hemato-onkologická klinika LF UP a FN v Olomouci
4 Ústav patologie LF UP a FN v Olomouci
5 Radiologická klinika LF UP a FN v Olomouci

Here we present the clinical course of a 15-year-old patient with metastatic Ewing sarcoma to bone marrow. MRI confirmed changes in

the marrow of long bones and molecular genetic studies revealed sensitive and specific Ewing sarcoma translocation (11;22) (q24;q12)

with creation of fusion gene EWSR1.

Keywords: Ewing sarcoma, pediatric, bone metastatic spread, cytogenetics, EWSR1

Published: April 25, 2012  Show citation

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Mihál V, Pospíšilová D, Novák Z, Ludíková B, Mathonová J, Jarošová M, et al.. Ewing sarcoma - a rare cause of joint and bone pain. Pediatr. praxi. 2012;13(2):126-129.
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    References

    1. Jedlicka P. Ewing sarcoma, an enigmatic malignancy of like progenitor cell origin, driven by transcription factor oncogenic fusions. Int J Clin Pathol 2010; 3(4): 338-347.
    2. DeLaney TF, Hornicek FJ, Mankin HJ. Clinical presentation, staging, and prognostic factors of the Ewing sarcoma family of tumors. www.uptodate.com, 2012.
    3. DeLanye TF, Hornicek FJ, Lessnick SL, Mankin HJ. Epidemiology, patology, and molecular genetics of the Ewing sarcoma family of tumors. www.uptodate.com, 2012.
    4. Meltzer PS. Is Ewing´s sarcoma a stem cell tumor? Cell Stem Cell 2007; 1: 13-15. Go to original source... Go to PubMed...
    5. Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing´s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing´s Sarcoma Study Group. J Clin Oncol 2000; 18(17): 3108-3114. Go to original source... Go to PubMed...
    6. Bhagavathi S, Fu K. Primary bone lymphoma. Arch Pathol Lab Med 2009; 133: 1868-1871. Go to original source...

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