Pediatr. praxi. 2013;14(4):235-238

Evaluation and treatment of children with suspected gastroesophageal reflux disease

MUDr.Ondřej Hradský, Ph.D.
Oddělení dětské gastroenterologie
Pediatrická klinika UK 2. LF a FN Motol, Praha

Work-up of children with suspected gastroesophageal reflux disease (GERD) has been dramatically changed recently. Multichannel

intraluminal impedance and 24h pH study become the most important diagnostic procedure. Now, ultrasound and barium contrast

studies are not recommended for the diagnosis of GERD. Because no optimal diagnostic method exists, the work-up has to be adapted

according to leading symptom. Proton pump inhibitors are very useful in treatment of GERD in patients where acid reflux is responsible

for symptoms. We have not suitable treatment option for pediatric patients with non-acid reflux related symptoms.

Keywords: gastroesophageal reflux disease, gastroesophageal reflux, esophageal pH monitoring, multichannel intraluminal impedance

Published: August 29, 2013  Show citation

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Hradský O. Evaluation and treatment of children with suspected gastroesophageal reflux disease. Pediatr. praxi. 2013;14(4):235-238.
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References

  1. Vandenplas Y, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 2009; 49(4): 498-547. Go to original source... Go to PubMed...
  2. Nelson SP, et al. Prevalence of symptoms of gastroesophageal reflux during childhood: a pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med, 2000; 154(2): 150-154. Go to original source... Go to PubMed...
  3. El-Serag HB, et al. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology 2001; 121(6): 1294-1299. Go to original source... Go to PubMed...
  4. Tolia V, Vandenplas Y. Systematic review: the extra-oesophageal symptoms of gastro-oesophageal reflux disease in children. Aliment Pharmacol Ther, 2009; 29(3): 258-272. Go to original source... Go to PubMed...
  5. Wenzl TG. Role of diagnostic tests in GERD. J Pediatr Gastroenterol Nutr. 53 Suppl 2: S4-6. Go to PubMed...
  6. Wenzl TG, et al. Indications, methodology, and interpretation of combined esophageal impedance-pH monitoring in children: ESPGHAN EURO-PIG standard protocol. J Pediatr Gastroenterol Nutr. 55(2): 230-234. Go to PubMed...
  7. Sifrim D, et al. Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut, 2005; 54(4): 449-454. Go to original source... Go to PubMed...
  8. Hassall E. Uses and abuses of acid-suppression therapy in children. J Pediatr Gastroenterol Nutr. 53(Suppl 2): S8-9. Go to PubMed...
  9. van der Pol R, et al. Non-pharmacological therapies for GERD in infants and children. J Pediatr Gastroenterol Nutr. 53(Suppl 2): S6-8. Go to PubMed...
  10. Horvath A, Dziechciarz P, Szajewska H. The effect of thickened-feed interventions on gastroesophageal reflux in infants: systematic review and meta-analysis of randomized, controlled trials. Pediatrics, 2008; 122(6): e1268-1277. Go to original source... Go to PubMed...
  11. Salvatore S, Vandenplas Y. Gastroesophageal reflux and cow milk allergy: is there a link? Pediatrics, 2002; 110(5): 972-984. Go to original source... Go to PubMed...
  12. Diaz DM, et al. Antireflux surgery outcomes in pediatric gastroesophageal reflux disease. Am J Gastroenterol, 2005; 100(8): 1844-1852. Go to original source... Go to PubMed...
  13. Knatten CK, et al. Thirty-day outcome in children randomized to open and laparoscopic Nissen fundoplication. J Pediatr Surg. 47(11): 1990-1996. Go to original source... Go to PubMed...
  14. Jeurnink SM, et al. Barrett's esophagus in children: does it need more attention? Dig Liver Dis. 43(9): 682-687.
  15. Stordal K, et al. Asthma and overweight are associated with symptoms of gastro-oesophageal reflux. Acta Paediatr 2006; 95(10): 1197-1201. Go to original source... Go to PubMed...
  16. Debley JS, Carter ER, Redding GJ. Prevalence and impact of gastroesophageal reflux in adolescents with asthma: a population-based study. Pediatr Pulmonol, 2006; 41(5): 475-481. Go to original source... Go to PubMed...
  17. Hughes DM, et al. Gastroesophageal reflux during sleep in asthmatic patients. J Pediatr, 1983; 102(5): 666-672. Go to original source... Go to PubMed...
  18. Hancox RJ, et al. Associations between respiratory symptoms, lung function and gastro-oesophageal reflux symptoms in a population-based birth cohort. Respir Res, 2006; 7: 142. Go to original source... Go to PubMed...
  19. Havemann BD, Henderson CA, El-Serag HB. The association between gastro-oesophageal reflux disease and asthma: a systematic review. Gut, 2007; 56(12): 1654-1664. Go to original source... Go to PubMed...
  20. Khoshoo V, Haydel, R. Jr. Effect of antireflux treatment on asthma exacerbations in nonatopic children. J Pediatr Gastroenterol Nutr, 2007; 44(3): 331-335. Go to original source... Go to PubMed...
  21. Rothenberg S, Cowles R. The effects of laparoscopic Nissen fundoplication on patients with severe gastroesophageal reflux disease and steroid-dependent asthma. J Pediatr Surg. 47(6): 1101-1104. Go to original source... Go to PubMed...
  22. Holbrook JT, et al. Lansoprazole for children with poorly controlled asthma: a randomized controlled trial. JAMA, 307(4): 373-381. Go to PubMed...
  23. Chang AB, et al. Gastro-oesophageal reflux treatment for prolonged non-specific cough in children and adults. Cochrane Database Syst Rev, (1): CD004823.
  24. Orenstein SR, et al. Multicenter, double-blind, randomized, placebo-controlled trial assessing the efficacy and safety of proton pump inhibitor lansoprazole in infants with symptoms of gastroesophageal reflux disease. J Pediatr, 2009; 154(4): 514-520 e4. Go to original source... Go to PubMed...
  25. Borrelli O, et al. Role of gastroesophageal reflux in children with unexplained chronic cough. J Pediatr Gastroenterol Nutr. 53(3): 287-292. Go to PubMed...
  26. Blondeau K, et al. The relationship between gastroesophageal reflux and cough in children with chronic unexplained cough using combined impedance-pH-manometry recordings. Pediatr Pulmonol.
  27. Greifer M, Ng K, Levine J. Impedance and extraesophageal manifestations of reflux in pediatrics. Laryngoscope. 122(6): 1397-1400. Go to original source... Go to PubMed...
  28. Block BB, Brodsky L. Hoarseness in children: the role of laryngopharyngeal reflux. Int J Pediatr Otorhinolaryngol, 2007; 71(9): 1361-1369. Go to original source... Go to PubMed...
  29. Mitzner R, Brodsky L. Multilevel esophageal biopsy in children with airway manifestations of extraesophageal reflux disease. Ann Otol Rhinol Laryngol, 2007; 116(8): 571-575. Go to original source... Go to PubMed...
  30. Contencin P, Narcy P. Gastropharyngeal reflux in infants and children. A pharyngeal pH monitoring study. Arch Otolaryngol Head Neck Surg, 1992; 118(10): 1028-1030. Go to original source... Go to PubMed...
  31. Bhat RY, et al. Acid gastroesophageal reflux in convalescent preterm infants: effect of posture and relationship to apnea. Pediatr Res, 2007; 62(5): 620-623. Go to original source... Go to PubMed...
  32. Molloy EJ, Di Fiore JM, Martin RJ. Does gastroesophageal reflux cause apnea in preterm infants? Biol Neonate, 2005; 87(4): 254-261. Go to original source... Go to PubMed...
  33. Sacre L. and Y. Vandenplas, Gastroesophageal reflux associated with respiratory abnormalities during sleep. J Pediatr Gastroenterol Nutr, 1989; 9(1): 28-33. Go to original source... Go to PubMed...
  34. Semeniuk J, et al. Is acid gastroesophageal reflux in children with ALTE etiopathogenetic factor of life threatening symptoms? Adv Med Sci, 2007; 52: 213-221.
  35. Kahn A, et al. Sleep apneas and acid esophageal reflux in control infants and in infants with an apparent life-threatening event. Biol Neonate, 1990; 57(3-4): 144-149. Go to original source... Go to PubMed...
  36. Tolia VA, Wuerth, Thomas R. Gastroesophageal reflux disease: review of presenting symptoms, evaluation, management, and outcome in infants. Dig Dis Sci, 2003; 48(9): 1723-1729. Go to original source... Go to PubMed...
  37. Kahn A, et al. Lack of temporal relation between acid reflux in the proximal oesophagus and cardiorespiratory events in sleeping infants. Eur J Pediatr, 1992; 151(3): 208-212. Go to original source... Go to PubMed...
  38. Linnett V, et al. Oral health of children with gastro-esophageal reflux disease: a controlled study. Aust Dent J, 2002; 47(2): 156-162. Go to original source... Go to PubMed...
  39. Ersin NK, et al. Oral and dental manifestations of gastroesophageal reflux disease in children: a preliminary study. Pediatr Dent, 2006; 28(3): 279-284. Go to PubMed...
  40. Pace F, et al. Systematic review: gastro-oesophageal reflux disease and dental lesions. Aliment Pharmacol Ther, 2008; 27(12): 1179-1186. Go to original source... Go to PubMed...
  41. Cerimagic D, Ivkic G, Bilic E. Neuroanatomical basis of Sandifer's syndrome: a new vagal reflex? Med Hypotheses, 2008; 70(5): 957-961. Go to original source... Go to PubMed...
  42. Kinsbourne M. Hiatus Hernia with Contortions of the Neck. Lancet, 1964; B 1(7342): 1058-1061. Go to original source... Go to PubMed...
  43. Khalaf MN, et al. Clinical correlations in infants in the neonatal intensive care unit with varying severity of gastroesophageal reflux. J Pediatr Gastroenterol Nutr, 2001; 32(1): 45-49. Go to original source... Go to PubMed...
  44. McKenna M, Brodsky L. Extraesophageal acid reflux and recurrent respiratory papilloma in children. Int J Pediatr Otorhinolaryngol, 2005; 69(5): 597-605. Go to original source... Go to PubMed...
  45. Wilder-Smith CH, et al. Quantification of dental erosions in patients with GERD using optical coherence tomography before and after double-blind, randomized treatment with esomeprazole or placebo. Am J Gastroenterol, 2009; 104(11): 2788-2795. Go to original source... Go to PubMed...




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