Pediatr. praxi. 2009;10(4):227-232
Immunization against pneumococci creates today already a cornerstone of immunization calendars in vast majority of developed countries
worldwide. A major reduction of invasive pneumococcal diseases in US is possible to consider as quite unquestionable success. In
the course of few years all problems seem not to be solved. Serotype 19A is a major issue in US, which otherwise did not disprove the
total benefit, however no doubts it limits overall impact. Similarly a replacement with non-vaccine serotypes in some other countries
decreases overall efficacy of such a provision. Future vaccines will have indeed extended coverage, however question is, if even they
solve all unanswered questions fully or it will be necessary to use different type of vaccines, e.g. protein.
Published: October 1, 2009 Show citation