Pediatr. praxi. 2009;10(4):227-232

Trends in prevention of pneumococcal infections in children

prof. MUDr. Roman Prymula DrSc., Ph.D
Katedra epidemiologie, Fakulta vojenského zdravotnictví, Hradec Králové

Immunization against pneumococci creates today already a cornerstone of immunization calendars in vast majority of developed countries

worldwide. A major reduction of invasive pneumococcal diseases in US is possible to consider as quite unquestionable success. In

the course of few years all problems seem not to be solved. Serotype 19A is a major issue in US, which otherwise did not disprove the

total benefit, however no doubts it limits overall impact. Similarly a replacement with non-vaccine serotypes in some other countries

decreases overall efficacy of such a provision. Future vaccines will have indeed extended coverage, however question is, if even they

solve all unanswered questions fully or it will be necessary to use different type of vaccines, e.g. protein.

Keywords: immunization calendar, IPD, pneumococcal conjugated vaccine, S. pneumoniae.

Published: October 1, 2009  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Prymula R, D P. Trends in prevention of pneumococcal infections in children. Pediatr. praxi. 2009;10(4):227-232.
Download citation

References

  1. Prymula R, Pospíšilová K. Současné přístupy k očkování konjugovanou pneumokokovou vakcínou. Prakt Lék 2008; 88(2): 106-109.
  2. Dinleyici EC, Yargic ZA. Pneumococcal conjugated vaccines: impact of PCV-7 and new achievements in the postvaccine era. Expert Rev Vaccines. 2008; 7(9): 1367-1394. Go to original source... Go to PubMed...
  3. O'Brien KL, Santosham M. Potential impact of conjugate pneumococcal vaccines on pediatric pneumococcal diseases. Am J Epidemiol 2004; 159: 634-644. Go to original source... Go to PubMed...
  4. World Health Organization Recommendations for production and control of pneumococcal conjugate vaccines. WHO Technical Report Series 2005; 927: 2.
  5. Henckaerts I, Durant N, De Grave D, Schuerman L, Poolman J. Validation of Routine High-throughput Pneumococcal Opsonophagocytosis Assays. Link with Clinical Efficacy. (Abstract DT.07). In: Proceedings of the Program and Abstracts of the 5th International Symposium on Pneumococci and Pneumococcal Diseases. Alice Springs (Australia); 2-6 April 2006.
  6. Ruan MR, Akkoyunlu M, Grubb A, Forsgren A. Protein D of Haemophilus influenzae. A novel bacterial surface protein with affinity for human IgD. J Immunol 1990; 145: 3379-3384. Go to original source...
  7. Křížová P, Prymula R, Marešová V, Motlová J, Beneš C. Pneumokoková onemocnění. Pediatr. pro Praxi 2009; 10(Suppl. B): 45 s.
  8. Prymula R, Peeters P, Chrobok V, Kriz P, Novakova E, Kaliskova E, et al. Pneumococcal capsular polysaccharides conjugated to protein D provide protection against otitis media caused by both Streptococcus pneumoniae and nontypable Haemophilus influenzae. Lancet 2006; 367: 740-748. Go to original source... Go to PubMed...
  9. Poolman J, Kriz P, Feron Ch, Di-Paolo E, Henckaerts I, Miseur A, et al. Pneumococcal serotype 3 otitis media, limited effect of polysaccharide conjugate immunisation and strain characteristics. Vaccin 2009; 27: 3213-3222. Go to original source... Go to PubMed...
  10. Prymula R, Chlibek R, Splino M, Kaliskova E, Kohl I, Lommel P, et al. Safety of the 11-valent pneumococcal vaccine conjugated to non-typeable Haemophilus influenzae-derived protein D in the first 2 years of life and immunogenicity of the co-administered hexavalent diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio virus, Haemophilus influenzae type b and control hepatitis A vaccines. Vaccine 2008; 26(35): 4563-4570. Go to original source... Go to PubMed...
  11. Chevallier B, Vesikari T, Brzostek J, Knuf M, Bermal N, Aristegui J, et al. Safety and reactogenicity of the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) when coadministered with routine childhood vaccines. Pediatr Infect Dis J. 2009; 28(4 Suppl): S109-118. Go to original source... Go to PubMed...




Pediatrics for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.