Pediatr. praxi. 2013;14(2):120-122

Ceftriaxone associated cholelithiasis and urolithiasis

prof.MUDr.Zdeněk Doležel, CSc.¹, MUDr.Zdeňka Ráčilová², MUDr.Veronika Texlová¹, MUDr.Helena Schneiderová¹

¹ Pediatrická klinika LF MU a FN Brno

² Klinika dětské radiologie LF MU a FN Brno

Ceftriaxone is a widely used third-generation cephalosporin that is generally considered very safe, but complications such as cholelithiasis

(the prefer term is pseudocholelithiasis), and rarely, nephrolithiasis have been reported in children. Despite several trials, the mechanisms

underlying the formation of ceftriaxone-associated pseudocholelithiasis and/or nephrolithiasis remain unclear. We here report a 8-year

old boy with aseptic meningoencephalitis complicated by pseudocholelithiasis and nephrolithiasis on the 6th day of treatment with

ceftriaxone. During treatment with ceftriaxone was diagnosed hypercalciuria. Ceftriaxone associated pseudocholelithiasis and nephrolithiasis

are transitory and usually without complications. In all patients who receive ceftriaxone is very important frequent ultrasound

examination of kidney and urinary/biliary tracts. It is therefore worthwhile to monitor the levels of urinary calcium to creatinine ratio in

patients on ceftriaxone, as they may be at greater risk for developing large stones and renal damage.

Keywords: ceftriaxone, pseudocholelithiasis, nephrolithiasis, hypercalciuria

Published: May 1, 2013  Show citation