Pediatr. praxi. 2017;18(2):110-113 | DOI: 10.36290/ped.2017.019

Glucan in the present medicine

prof. RNDr. Václav Větvička, Ph.D.1, MUDr. Josef Richter, CSc.2, MUDr. Vladimír Svozil3
1Univerzita Louisville, Oddělení Patologie, Louisville, USA, 2Zdravotní ústav se sídlem v Ústí nad Labem, 3Sanatorium EDEL, Zlaté Hory

Glucan is a natural immunomodulator intensivelly studied the past twenty years. Besides the known effects in infectious and

tumor immunity, the interest of researchers in the recent years focused on its other potential effects. The aim of this short review

is to provide basic information about glucan. The list is completed with results of our own clinical examination, demonstrating

a significant stimulatory effects of short time glucan supplementation in the group of children with diseases of the respiratory tract.

Keywords: beta glucan, salivary IgA, IgM, IgG, 6MWT

Published: May 1, 2017  Show citation

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Větvička V, Richter J, Svozil V. Glucan in the present medicine. Pediatr. praxi. 2017;18(2):110-113. doi: 10.36290/ped.2017.019.
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    References

    1. Busch W. Verhandlungen artzlicher Gesellschaften. Sitzung der medizinischen Section vom 18. November 1867. Berl Klin Wochenschr 1968; 5: 137-138.
    2. Bickels J, KollenderY, Merinsky O, Meller I. Coley's toxin: Historical perspective. Israel Med Ass J 2002; 4: 471-472.
    3. Coley WB. The treatment of malignant tumors by repeated inoculations of erysipelas: with a report of ten original cases.Am J Med Sci 1893; 105: 487-511. Go to original source...
    4. Shear mJ, Turner FC, Perrault A, Shovelton T. Clinical treatment of tumors.V. Isolation of the hemorrhage-producing fraction from Serratia Marcescens (Bacillus prodigiosus) culture filtrates. J Natl Cancer Inst 1943; 4: 81-97.
    5. DiLuzio NR, Riggi SJ. The effects of laminarin, sulfated glucan and oligosacchrides of glucan on reticuloendothelial aktivity. J Reticuloendothel Soc 1970; 8: 465-473. Go to PubMed...
    6. Chihara G, Maeda YY, Hamuro J, Sasaki T, Fukuoka F. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk.) sing. Nature 1969; 222: 687-688. Go to original source... Go to PubMed...
    7. Stratford M. Another brick in the wall? Recent developments concerning the yeast cell envelopa. Yeast 1994; 10: 1741-1752. Go to original source... Go to PubMed...
    8. Kogan G. (1-3,1-6)-?-D-glucans of yeast and fungi and theuir biological aktivity. In: Studies in Natural Products Chemisry, Vo. 23., Ed. Atta-ur-Rahman, Elsevier, Amsterdam, 2000: 107-117.
    9. Kabat EA. Structural Concepts in Immunology and Immunochemistry. Holt, Rinehart and Winston, New York, 1976.
    10. Vetvicka V. ?-Glucans as Natural Biological Response Modifiers. Nova Biomedical, New York, 2013.
    11. Vetvicka V, Sima P. ?-Glucan in invertebrates. Invertebrate Survival J. 2004; 1: 60-65.
    12. Bergendiova K, Tibenska E, Majtan J. Pleuran (-glucan from Pleurototus ostreatus) supplementation, cellular immune response and respirátory tractinfections in athletes. Eur J Applied Physiol 2011; 111: 2033-2040. Go to original source... Go to PubMed...
    13. Lehne G, Haneberg B, Gaustad P, Johansen PW, Preus H, Abrahamsen TG. Oral administration of a new soluble branched ?-1,3-D-glucan is well tolerated and can lead to increased salivary concentrations of immunoglobulin A in healthy voluteers. Clin Exper Immunol 2005; 143: 65-69. Go to original source... Go to PubMed...
    14. Ramberg JE, Nelson ED, Sinnot RA. Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J 2010; 9: 1-22. Go to original source... Go to PubMed...
    15. Li AM, Yin J,Yu CCW, et al. The six-minute walk test in healthy children: reliability and validity. Eur Respir J 2005; 25: 1057-1060. Go to original source... Go to PubMed...
    16. American Thoracic Society Documents. ATS/ERS Recomandations for standardized procedures for the online and offline measurement of exhaled lowerrespiratory nitric oxide and nasal nitric oxida. Am J Respir Crit Care Med 2005; 171: 912-930. Go to original source...
    17. Ambatipudi KS, Lu B, Hagen FK, Melvin JE, Yates JR. Quantitative analysis of age specific variation in the abundance of human female parotid salivary proteins. J Proteome Res 2009; 8: 5093-5102. Go to original source... Go to PubMed...
    18. Brown LR, Frome WJ, Wheatcroft MG. The effect of Skylab on the chemical composition of saliva. J Dent Res 1977: 1137-1143. Go to original source... Go to PubMed...
    19. Castagnola M, Picciotti PM, Messana I, et al. Potential applications of human saliva as diagnostic fluid. Acta Otorhinolaryngol Ital 2011; 31: 347-357. Go to PubMed...
    20. American Thoracic Society. ATS Statement: Guidlines for the Six-minute Walk Test. Am J Respir Care Med 2002; 166: 111-117. Go to original source... Go to PubMed...
    21. Casanova C, Celli BR, Barria P, et al. The 6-min walk distance in healthy subjects: reference standards from seven countries. Europ Respir J 2011; 37: 150-156. Go to original source... Go to PubMed...
    22. Karakurt Z, Guven O, Mocin O, et al. Six minute walking distatnce in kyphoscoliosis patients with chronic respiratory failure. Multidisciplinatory Resp Med 2010; 5: 244-249. Go to original source... Go to PubMed...
    23. Li AM, Yin J, Au JT, et al. Standardreference for the Six-minute-walk test in healthy children aged 7 to 16 years. AmJ Respir Crit Care Med 2007; 176: 174-180. Go to original source...
    24. Vetvicka V, Richter J, Svozil V, et al. Placebo-driven clinical trials of Transfer Point Glucan 300 in children with chronic respirátory problems: Antibody production. Am J Immunol 2013; 9: 43-47. Go to original source...
    25. Richter J, Svozil V, Kral V, et al. Cllinical trials of yeast-derived ?-(1-3) glucan in children" effects on innate immunity. Ann Transl Med 2014; 2: doi: 10.3978/j.issn.2305-5839.2014.02.01.
    26. Vetvicka V, Richter J, Svozil V, et al. Placebo driven clinical trials of Transfer Point Glucan 300 in children with chronic respirátory problems: III. Clinical findings. Am J Immunol 2013; 9(3): 88-93. Go to original source...
    27. Stuyven E, Verdonck F, Hoek Van I, et al. Oral administration of ?-1,3/1,6-Glucan to Dogs Temporally Changes Total and Antigen-Specific IgA and IgM. Clin Vaccine Immunol 2010; 17: 281-286. Go to original source... Go to PubMed...
    28. Šíma P, Turek B, Bencko V. Betaglukany-imunomodulační látky v prevenci a podpůrné léčbě. Praktický lékař 2015? 95: 244-248.
    29. Bencko V, Šíma P, Turek B. Imunomodulační účinky betaglukanů. Hygiena 2016? 61: 167-171. Go to original source...
    30. Kocmanová I, Ráčil Z, Koukalová D, Mayer J. Laboratorní stanovení 1,3-?-D-glukanu a jeho využití v diagnostice invazivních mykóz. Klin mikromol inf lék 2008? 14: 88-92.

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