Pediatr. praxi. 2020;21(4):290-294 | DOI: 10.36290/ped.2020.059

Severe hypernatremia in an infant with a central nervous system developmental disorder

MUDr. Petr Jabandžiev, Ph.D.1,2,3, MUDr. Jakub Pecl1,2, MUDr. Martin Jouza1,2, MUDr. Jiří Štarha, Ph.D.1, MUDr. Jan Papež1,2, MUDr. Milan Urík, Ph.D.2,4, MUDr. Anna Seehofnerová2,5, MUDr. Ondřej Horák2,6
1 Pediatrická klinika, Fakultní nemocnice Brno
2 Lékařská fakulta, Masarykovy univerzity v Brně
3 Středoevropský technologický institut - CEITEC, Brno
4 Klinika dětské otorhinolaryngologie, Fakultní nemocnice Brno
5 Klinika dětské radiologie, Fakultní nemocnice Brno
6 Klinika dětské neurologie, Fakultní nemocnice Brno

We present acase report of an infant with septooptic dysplasia variant (holoprosencephaly spectrum) with accidentally found severe hypernatremia. The case report points to the possibility of coincidence of hypopituitarism in patients with this form of forebrain malformation. Combined primary endocrine deficits in neonates and infants may result in derangement of body internal environment. Severe hypernatremia due to central diabetes insipidus is one of the potentially fatal complications requiring avery gradual, strictly controlled correction of the internal environment parameters. This is the only way to prevent serious neurological complications due to the rapidly changing internal environment.

Keywords: hypernatremia, polyuria, diabetes insipidus, holoprosencephaly.

Published: September 3, 2020  Show citation

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Jabandžiev P, Pecl J, Jouza M, Štarha J, Papež J, Urík M, et al.. Severe hypernatremia in an infant with a central nervous system developmental disorder. Pediatr. praxi. 2020;21(4):290-294. doi: 10.36290/ped.2020.059.
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