Pediatr. praxi. 2025;26(4):265-270

Some functional disorders of the gastrointestinal tract in infants and their management

doc. MUDr. Milan Kuchta, CSc.
Klinika detí a dorastu LF UPJŠ a DFN Košice

Introduction: The postnatal adaptation of a child to extrauterine life is a very complex process and occurs with different sequences and different "speeds". From this point of view, the manifestations of adaptation of the digestive tract may not always be correctly understood and interpreted and may have varied symptoms. Several symptoms may not be "pathological" manifestations but adaptation manifestations. These manifestations are usually transient and do not seriously threaten the child. Examples include infant grumbling or infant colic. Context: It is necessary to realize that many functional disorders of the digestive tract result from the gradual adaptation of the child's digestive tract to changes in diet, neuropsychic and physical growth development, and bio-psycho-social aspects of the interaction of the intestine and the brain. The most comprehensive classification of functional gastrointestinal disorders is given in the Rome criteria. So far, the latest edition is from 2016 (Rome IV). Still, Rome V is already in preparation (planned edition 2026), in which the term "functional disorders" is replaced by the term "GIT-CNS interaction disorders". The new Rome V classification, also based on EBM knowledge and in accordance with the acceptance of the concept of the "brain/gut axis", will help speed up and make the diagnosis and therapy of functional gastrointestinal disorders (FGID) more effective even in infancy. It should also greatly help paediatricians working in general practitioners' clinics for children and adolescents.

Conclusion: Acceptance of the bio-psycho-social model of functional gastrointestinal disorders is essential not only for children with difficulties and their families but also has economic significance. Understanding the origin and existence of difficulties brings significant savings for unperformed (and in most cases also not indicated) examinations.

Keywords: infant, toddler, regurgitation, functional gastrointestinal disorders, Rome criteria, brain/gut axis.

Published: September 26, 2025  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kuchta M. Some functional disorders of the gastrointestinal tract in infants and their management. Pediatr. praxi. 2025;26(4):265-270.
Download citation

References

  1. . Baldassarre ME, Antonucci LA, Castoro G, et al. Maternal Psychological Factors and Onset of Functional Gastro­intestinal Disorders in Offspring: A Prospective Study. J Pediatr Gastroenterol Nutr. 2021;73(1):30-36. doi: 10.1097/MPG.0000000000003107. Go to original source... Go to PubMed...
  2. . Benninga MA, et al. Childhood Functional Gastrointestinal Disorders: Neonate/Toddler. Gastroenterology. 2016;150: 1443-1455. Go to original source... Go to PubMed...
  3. . Di Lorenzo C. Other functional gastrointestinal disorders in infants and young children. J Pediatr Gastroenterol Nutr. 2013;57(Suppl 1):S36-S38. Go to original source...
  4. . Drossman DA, Tack J, et al. Rome Foundation Clinical Diagnostic Criteria for Disorders of Gut-Brain Interaction. Gastroenterology. 2021;162(3):675-679. doi: 10.1053/j.gastro.2021.11.019. Go to original source... Go to PubMed...
  5. . Fernández-González SM, Moreno-Álvarez A, Solar-Boga A. Proton Pump Inhibitors in Pediatric Gastroesophageal Reflux Disease: A Systematic Review of Randomized Controlled Trials. Children. 2024;11:296. doi: 10.3390/children11030296. Go to original source... Go to PubMed...
  6. . Foster JP, Dahlen HG, Fijan S, et al. Probiotics for preventing and treating infant regurgitation: A systematic review and meta-analysis. Matern Child Nutr. 2022;18(1):e13290. doi: 10.1111/mcn.13290. Go to original source... Go to PubMed...
  7. . Haiden N, Savino F, Hill S, et al. Infant formulas for the treatment of functional gastrointestinal disorders: A position paper of the ESPGHAN Nutrition Committee. J Pediatr Gastro­enterol Nutr. 2024;79(1):168-180. doi: 10.1002/jpn3.12240. Go to original source... Go to PubMed...
  8. . Happy Tummy Consortium, Lavalle L, Sauvageot N, et al. Limosilactobacillus reuteri DSM 17938-Containing Infant Formulas and the Associations with Gastrointestinal Tolerance: A Cross-Sectional Observational Study. Nutrients. 2023;15(3):530. doi: 10.3390/nu15030530. Go to original source... Go to PubMed...
  9. . Hojšak I, Kolaček S, Mihatsch W, et al. Working Group on Probiotics and Prebiotics of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Synbiotics in the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications. J Pediatr Gastroenterol Nutr. 2022;76(1):102-108. doi: 10.1097/MPG.0000000000003568. Go to original source... Go to PubMed...
  10. . Hradský O, Bajerová K, El-Lababidi N, et al. Diagnostika a liečba refluxného ochorenia u detí: Český zjednotený odporúčaný postup z pohľadu gastroenterológa, pneumológa, ORL lekára, neonatológa a chirurga. Čes-slov Pediat. 2016;71(1):3-43.
  11. . Chouraqui J-P, Brancato S, Delmas B, et al. Effectiveness of a starch thickened infant formula with reduced lactose content, probiotics and prebiotics on quality of life and clinical outcome in infants with regurgitation and/or colic. Front Nutr. 2023;10:1164722. doi: 10.3389/fnut.2023.1164722. Go to original source... Go to PubMed...
  12. . Indrio F, Di Mauro A, Riezzo G, et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr. 2014;168(3):228-233. Go to original source... Go to PubMed...
  13. . Indrio F, Riezzo G, Giordano P, et al. Effect of a Partially Hydro­lysed Whey Infant Formula Supplemented with Starch and Lactobacillus reuteri DSM 17938 on Regurgitation and Gastric Motility. Nutrients. 2017;9(11):1181. doi: 10.3390/nu9111181. Go to original source... Go to PubMed...
  14. . Indrio F, Gutierrez Castrellon P, Vandenplas Y, et al. Health Effects of Infant Formula Supplemented with Probiotics or Synbiotics in Infants and Toddlers: Systematic Review with Network Meta-Analysis. Nutrients. 2022;14(23):5175. doi: 10.3390/nu14235175. Go to original source... Go to PubMed...
  15. . Jakušová Ľ, Havlíčeková Z. Funkčné poruchy tráviaceho systému v detskom veku. Pediatria (Bratisl.). 2008;3(2):93-97.
  16. . Keefer L, et al. A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction. Gastroenterology. 2021;162(1):300-315. doi: 10.1053/j.gastro.2021.09.015. Go to original source... Go to PubMed...
  17. . Kolaček S, Hojšak I, Berni Canani R, et al. Commercial Probiotic Products: A Call for Improved Quality Control. A Position Paper by the ESPGHAN Working Group for Probiotics and Prebiotics. J Pediatr Gastroenterol Nutr. 2017;65(1):117-124. doi: 10.1097/MPG.0000000000001603. Go to original source... Go to PubMed...
  18. . Kuchta M, Ďurošková Z. Niektoré funkčné poruchy gastrointestinálneho traktu dojčiat a batoliat v nadväznosti na rímske kritériá. Pediatria (Bratisl.). 2022;17(2):69-73.
  19. . Leung AK, Hon KL. Gastroesophageal reflux in children: an updated review. Drugs Context. 2019;8:212591. doi: 10.7573/dic.212591. Go to original source... Go to PubMed...
  20. . Mearin F, Lacy BE, Chang L, et al. Rome IV functional gastrointestinal disorders - disorders of gut-brain interaction. Volume II. Raleigh, NC: The Rome Foundation; 2016:967-1057.
  21. . Minárik P, Mináriková D. Funkčné črevné poruchy a ich liečba. Prakt Lekárn. 2019;9(1):6-13.
  22. . Morais LH, Schreiber HL, Mazmanian SK. The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol. 2021;19(4):241-255. doi: 10.1038/s41579-020-00460-0. Go to original source... Go to PubMed...
  23. . Nurko S, Benninga MA, Solari T, et al. Pediatric Aspects of Nutrition Interventions for Disorders of Gut-Brain Interaction. Am J Gastroenterol. 2022;117(6):995-1009. doi: 10.14309/ajg.0000000000001779. Go to original source... Go to PubMed...
  24. . Ondrejčíková K, Kuchta M, Ďurošková Z. Funkčné potraviny a možnosti ich využitia v pediatrii. Pediatria (Bratisl.). 2020;15(1):13-19.
  25. . Pärtty A, Rautava S, Kalliomäki M. Probiotics on Pediatric Functional Gastrointestinal Disorders. Nutrients. 2018; 10(12):1836. doi: 10.3390/nu10121836. Go to original source... Go to PubMed...
  26. . Qian J, Fang Z, Chang S, et al. Effectiveness and safety study of formula containing probiotics, prebiotics, synbiotics on fullterm infants' growth - a systematic review and meta-analysis of randomized controlled study. Eur J Clin Nutr. 2024; 79:504-511. doi: 10.1038/s41430-024-01506-9. Go to original source... Go to PubMed...
  27. . Scarpato E, Salvatore S, Romano C, et al. Prevalence and Risk Factors of Functional Gastrointestinal Disorders: A Cross-Sectional Study in Italian Infants and Young Children. J Pediatr Gastroenterol Nutr. 2023;76(2):e27-e35. doi: 10.1097/MPG.0000000000003653. Go to original source... Go to PubMed...
  28. . Van Oudenhove L, Crowell MD, Drossman DA, et al. Bio­psychosocial Aspects of Functional Gastrointestinal Disorders. Gastroenterology. 2016; S0016-5085(16)00218-3. doi: 10.1053/j.gastro.2016.02.027. Go to original source... Go to PubMed...
  29. . Vandenplas Y, Abkari A, Bellaiche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr. 2015;61:531-537. Go to original source... Go to PubMed...




Pediatrics for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.