Pediatr. praxi. 2011;12(2):108-110

When the treatment of infantile haemangiomas is indicated?

prof.MUDr.Vladimír Mihál, CSc.1, MUDr.Zbyněk Novák1, Eva Hůlková1, MUDr.Kamila Michálková2
1 Dětská klinika LF UP a FN v Olomouci
2 Radiologická klinika LF UP a FN v Olomouci

Infantile haemangiomas (IH) are the most common benign tumours of infancy. Although most IH are innocuous and 85–90 % regress

spontaneously, some may become life- or function-threatening and require immediate treatment. Previous standard therapeutic options

include systemic corticosteroids, in severe cases also vincristine, -interferon α or cyclophosphamide, all bearing the risk of serious

side-effects. Oral propranolol is a very recent therapeutic option for complicated (alarming) IH with impressive efficacy and generally

good tolerance.

Keywords: complicated (alarming) infantile haemangiomas, propranolol

Published: April 18, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Mihál V, Novák Z, Hůlková E, Michálková K. When the treatment of infantile haemangiomas is indicated? Pediatr. praxi. 2011;12(2):108-110.
Download citation

References

  1. Enjolras O, Mulliken JB. Vascular tumors and vascular malformations (new issues). Adv Dermatol, 1997; 13: 375-423. Go to PubMed...
  2. Mihál V, Michálková K, Horák D, et al. Náhle vzniklé polykací potíže jako první projev sublinguálního kavernózního hemangiomu. Pediatr praxi 2003; 2: 99-102.
  3. Mihál V, Michálková K, Novák Z, et al. Kapilární hemangiom sleziny. Pediatr. praxi 2004; 4: 214-216.
  4. Bennett ML, Fleischer AB. Jr, Chamlin SL, et al. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidencebased evaluation. Arch Dermatol, 2001; 137: 1208-1213. Go to original source... Go to PubMed...
  5. Ezekowitz RA, Mulliken JB, Folkman J. Interferon alfa-2a therapy for life-threatening hemangiomas of infancy. N Engl J Med, 1992; 326: 1456. Go to original source... Go to PubMed...
  6. Justová E, Pazdera J, Mihál V. Systémová terapie interferonem alfa u nemocných s nádory z vazoformativní tkáně a infantilní fibromatózy. Česko-Slov Pediatr, 1998; 143(2): 53.
  7. Justová E, Pazdera J, Mihál V. Contemporary possibilities of treating vasoformative tissue tumours. Acta Univ Palacki Olomouc Fac Med, 2000; 143: 37-42. Go to original source... Go to PubMed...
  8. Justová E, Mihál V, Pazdera J. Sklerotizace v terapii nádorů z vazoformativní tkáně. Pediatr. praxi, 2007; 3: 173-175.
  9. Léauté-Labr?ze C, Dumas DE, la Roque E, Hubice T, et al. Propranolol for severe hemangiomas of infanty. N Engl J Med, 2008; 358: 2649-2651. Go to original source... Go to PubMed...
  10. Cheng JF, Gole GA, Sullivan TJ. Propranolol in the management of periorbital infantile haemangioma. J Exp Ophtal, 2010; 38: 547-553. Go to original source... Go to PubMed...
  11. Maguiness SM, Frieden IJ. Current management of infantile hemangiomas. Semin Cutan Med Surg, 2010; 29: 106-114. Go to original source... Go to PubMed...
  12. Schiestl C, Neuhaus K, Zoller S, et al. Efficacy and safety of propranolol as first-line treatment for infantile hemangiomas. Eur J Pediatr, 2010; doi 10.1007/s00431-010-1324-2. Go to original source... Go to PubMed...
  13. Garin EH, Araya CE. Treatment of systemic hypertension in children and adolescents. Curr Opin Pediatr, 2009; 21: 600-604. Go to original source... Go to PubMed...
  14. Storch CH, Hoeger PH. Propranolol for infantile haemangiomas-insights into the molecular mechanisms of action. Br J Dermatol, 2010; 163: 269-274. 6. Greene AK. Management of hemangiomas and other vascular tumors. Clin Plast Surg, 2011; 38: 45-63. Go to original source... Go to PubMed...
  15. Manunza F, Syed S, Laguna B, et al. Propranolol for complicated infantile haemangiomas: a case series of 30 infants. Br J Dermatol, 2010; 162: 466-468. Go to original source... Go to PubMed...
  16. Metry DW. Epidemiology; pathogenesis; clinical features; and complications of infantile hemangiomas. Dostupné na: http://www.uptodate.com.
  17. Pavlakovic H, Kietz S, Lauerer P, et al. Hyperkalemia complicating propranolol treatment of an infantile hemangioma. Pediatrics 2010; 126(6): 1589-1593. Go to original source... Go to PubMed...
  18. Breur JM, de Graf M, Breugem CC, et al. Hypoglycemia as a result of propranolol during treatment of infantile hemangioma: a case report. Pediatr Dermatol, 2010, Abstrakt. Go to original source...
  19. Holland KE, Frieden IJ, Frommelt PC, et al. Hypoglycemia in children taking propranolol for the treatment of infantile hemangioma. Arch Dermatol, 2010; 146: 775-778. Go to original source... Go to PubMed...




Pediatrics for Practice

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.