Pediatr. praxi. 2013;14(3):174-176

The new possibilities of compounded oral and rectal preparations in pediatrics

PharmDr.Zbyněk Sklenář, Ph.D., MBA1, Mgr.Kateřina Horáčková2,3, doc.MUDr.Ondřej Slanař, Ph.D.1
1 Univerzita Karlova v Praze, 1. lékařská fakulta, Farmakologický ústav
2 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra analytické chemie
3 Lékárna Na Rohožníku, Praha

This paper offers extemporaneous preparation possibilities of non-sterile dosage forms intended for gastrointestinal application with

systemic effect for children in five compounds newly available for magistral preparation in pharmacies. These new substances are

domperidon, propranolol hydrochloride, sotalol hydrochloride, promethazine hydrochloride and alpha tocopherol acetate. This increases

treatment possibilities with these new substances, and the doses can be customized to the paediatric patient. This article gives

brief information about these compounds and presents examples of compounded formulas suitable for use in paediatric practice.

Keywords: magistral preparation, compounded formulas, pediatric dosage forms, domperidone oral suspension, infantile hemangiomas,

Published: July 15, 2013  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Sklenář Z, Horáčková K, Slanař O. The new possibilities of compounded oral and rectal preparations in pediatrics. Pediatr. praxi. 2013;14(3):174-176.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Státní ústav pro kontrolu léčiv, databáze léků. Dostupné z: http://www.sukl.cz/modules/medication/search.php [cit. 2011-12-15].
    2. Sklenář Z, Horáčková K. Nové léčivé látky v magistraliter receptuře XI - domperidon. Prakt. Lékáren. 2011; 7(5): 236-238.
    3. O'Meara A, Mott MG. Domperidone as an antiemetic in paediatric oncology. Cancer Chemother Pharmacol. 1981; 6(2): 147-149. Go to original source... Go to PubMed...
    4. http://home.intekom.com/pharm/janssen/motili-s.html [cit. 2011-12-02].
    5. http://www.pharmazie.com/graphic/A/12/0-17412.pdf [cit. 2011-12-02].
    6. Truong MT, Perkins JA, Messner AH, Chang KW. Propranolol for the treatment of airway hemangiomas: A case series and treatment algorithm. Int J Pediatr Otorhinolaryngol. 2010; 74(9): 1043-1048. Go to original source... Go to PubMed...
    7. Hermans DJ, van Beynum IM, Schultze Kool LJ, et al. Propranolol, a very promising treatment for ulceration in infantile hemangiomas: a study of 20 cases with matched historical controls. J Am Acad Dermatol. 2011; 64(5): 833-838. Go to original source... Go to PubMed...
    8. Leaute-Labreze C, Dumas DE, la Roque E, Hubice T, et al. Propranolol for severe hemangiomas of infanty. N Engl J Med 2008; 358(24): 2649-2651. Go to original source... Go to PubMed...
    9. Sklenář Z, Horáčková K. Nové léčivé látky v magistraliter receptuře XII - Propranolol-hydrochlorid. Prakt. Lékáren. 2012; 8(1): 25-27.
    10. Gupta VD, Stewart KR. Stability of propranolol hydrochloride suspension and solution compounded from injection or tablets. Am J Hosp Pharm 1987; 44: 360-362. Go to original source...
    11. Rowe RC, Sheskey PJ, Owen SC. Pharmaceutical excipients 2004 (Singleuser version). [CD-ROM]. Washington, DC: Pharmaceutical Press and American Pharmacists Association 2004.
    12. Sklenář Z, Horáčková K. Nové léčivé látky v magistraliter receptuře XIII - Sotalol-hydrochlorid. Prakt. Lékáren. 2012; 8(1): 28-30.
    13. Dupuis LL, James G, Bacola G. Stability of a sotalol hydrochloride oral liquid formulation. Can J Hosp Pharm 1988; 41(3): 121-123.
    14. Sklenář Z, Horáčková K. Nové léčivé látky v magistraliter receptuře V - Promethazin-hydrochlorid. Prakt. Lékáren. 2010; 6(6): 300-302.
    15. Fajt M. Dušení při postižení v oblasti horních dýchacích cest u dětí. Pediatr. praxi 2004; 5(1): 25-30.
    16. Wynn RL, Meiller TF, Crossley HL. Drug information handbook for dentistry. 15th ed. Ohio: Lexi-Comp 2009: 2223 p.
    17. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm126465.htm [cit. 2010-11-01].
    18. http://www.hhsc.state.tx.us/hcf/vdp/Criteria/promethazine.pdf [cit. 2010-11-01].
    19. Seznam československých farmaceutických přípravků 1980-1984. Praha: Spofa 1980: 210.

    Return to the content


    Pediatrics for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.