Pediatr. praxi. 2023;24(6):394-397 | DOI: 10.36290/ped.2023.095

Cow´s Milk-related Symptom Score - is there anything new?

MUDr. Kateřina Bajerová, Ph.D.
Pediatrická klinika, FN Brno a LF MU Brno
TriannyMed, s. r. o., ordinace PLDD, Brno

The cow´s milk protein allergy (CMPA) is the most frequent allergy of infants and toddlers. It is challenging to early recognize the suspected patient and if indicated, start the diagnostic elimination followed by an oral challenge. To help the medical health care provider to identify infant at allergy risk experts published the Cow´s Milk Related Symptom Score (CoMiSS). The questionnaire brings a relevant overview of CMPA symptoms´ intensity and helps to work out the CMPA correctly. In 2022 the CoMiSS was updated: the cut-off decreased from ≥ 12 to ≥ 10, the Bristol Stool Scale was substituted by the Brussels Infant and Toddler Stool Scale intended for non-toilet trained subjects, an angioedema was included as a new symptom with equal rating as urticaria.

Keywords: cow´s milk protein allergy, Cow´s Milk-Related Symptom Score, CoMiSS.

Accepted: November 14, 2023; Published: November 22, 2023  Show citation

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Bajerová K. Cow´s Milk-related Symptom Score - is there anything new? Pediatr. praxi. 2023;24(6):394-397. doi: 10.36290/ped.2023.095.
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    References

    1. Zheng HS, Zhu WJ, Liu CH, et al. Clinical characteristics of children with IgE-mediated cow's milk protein allergy. Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Aug 6;57(8):1271-1279. Chinese. doi: 10.3760/cma.j.cn112150-20230514-00370. PMID: 37574323. Go to original source... Go to PubMed...
    2. Vandenplas Y, Broekaert I, Domellöf M, et al. An ESPGHAN position paper on the diagnosis, management and prevention of cow's milk allergy. J Pediatr Gastroenterol Nutr. 2023; Jul 26. doi: 10.1097/MPG.0000000000003897. Epub ahead of print. PMID: 37491714. Go to original source... Go to PubMed...
    3. Lozinsky AC, Meyer R, Anagnostou K, et al. Cow's Milk Protein Allergy from Diagnosis to Management: A Very Different Journey for General Practitioners and Parents. Children. Children (Basel). 2015 Jul 21;2(3):317-29. doi: 10.3390/children2030317. PMID: 27417366; PMCID: PMC4928770. Go to original source... Go to PubMed...
    4. Fiocchi A, Bognanni A, Brożek J, et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow's Milk Allergy (DRACMA) Guideline update - VII - Milk elimination and reintroduction in the diagnostic process of cow's milk allergy. World Allergy Organ J. 2022 Feb 1;15(1):100609. doi: 10.1016/j.waojou.2021.100609. PMID: 35145603; PMCID: PMC8818560. Go to original source... Go to PubMed...
    5. Vandenplas Y, Dupont C, Eigenmann P, et al. A workshop report on the development of the Cow's Milk-related Symptom Score awareness tool for young children. Acta Paediatr. 2015;104(4):334-9. Go to original source... Go to PubMed...
    6. Muñoz-Urribarri A, Sabrá A, Sabrá S, et al. A Trial of an Anamnesis-based Score Applied as a Diagnostic Tool for Cow's Milk Protein Allergy in Children. J Pediatr Gastroenterol Nutr. 2021 Apr 1;72(4):e86-e89. doi: 10.1097/MPG.0000000000003031. PMID: 33394886. Go to original source... Go to PubMed...
    7. Gibbons TE, Patil SN, Frem JC, et al. Non-IgE-mediated cow milk allergy is linked to early childhood clusters of commonly seen illnesses: a pilot study. Clin Pediatr (Phila). 2012 Apr;51(4):337-44. doi: 10.1177/0009922811425234. Epub 2011 Oct 19. PMID: 22013147. Go to original source... Go to PubMed...
    8. Bajerova K, Salvatore S, Dupont C, et al. The Cow's Milk-Related Symptom Score (CoMiSSTM): A Useful Awareness Tool. Nutrients. 2022 May 14;14(10):2059. doi: 10.3390/nu14102059. PMID: 35631201; PMCID: PMC9146599. Go to original source... Go to PubMed...
    9. Vandenplas Y, Salvatore S, Ribes-Koninckx C, et al. The Cow Milk Symptom Score (CoMiSSTM) in presumed healthy infants. PLOS ONE. 2018; July 18. https://doi.org/10.1371/journal.pone.0200603 2018;13(7):e0200603. Go to original source...
    10. Vandenplas Y, Gerlier L, Caekelbergh K, et al. An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders. Nutrients. October 2021;13(10):3336. Go to original source... Go to PubMed...
    11. Salvatore S, Bertoni E, Bogni F, et al. Testing the Cow's Milk-Related Symptom Score (CoMiSSTM) for the Response to a Cow's Milk-Free Diet in Infants: A Prospective Study. Nutrients. 2019 Oct 8;11(10):2402. doi: 10.3390/nu11102402. PMID: 31597323; PMCID: PMC6835327. Go to original source... Go to PubMed...
    12. Sirin Kose S, Atakul G, Asilsoy S, et al. The efficiency of the symptom-based score in infants diagnosed with cow's milk protein and hen's egg allergy. Allergol Immunopathol (Madr). Jun 2019;47(3):265-71. Go to original source... Go to PubMed...
    13. Vandenplas Y, Bajerova K, Dupont C, et al. The Cow's Milk Related Symptom Score: The 2022 Update. Nutrients. 2022 Jun 28;14(13):2682. doi: 10.3390/nu14132682. PMID: 35807862; PMCID: PMC9268587.. Go to original source... Go to PubMed...
    14. Gulati R, Komuravelly A, Leb S, et al. Usefulness of Assessment of Stool Form by the Modified Bristol Stool Form Scale in Primary Care Pediatrics. Pediatr Gastroenterol Hepatol Nutr. 2018 Apr;21(2):93-100. doi: 10.5223/pghn.2018.21.2.93. Epub 2018 Apr 13. PMID: 29713606; PMCID: PMC5915696. Go to original source... Go to PubMed...
    15. Vandenplas Y, Szajewska H, Benninga M, et al. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29;7(3):e014620. doi: 10.1136/bmjopen-2016-014620. PMID: 28360250; PMCID: PMC5372036. Go to original source... Go to PubMed...
    16. Huysentruyt K, Koppen I, Benninga M, et al. The Brussels Infant and Toddler Stool Scale: A Study on Interobserver Reliability. J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):207-213. doi: 10.1097/MPG.0000000000002153. PMID: 30672767. Go to original source... Go to PubMed...
    17. Aman BA, Levy EI, Hofman B, et al. Real Time Versus Photographic Assessment of Stool Consistency Using the Brussels Infant and Toddler Stool Scale: Are They Telling Us the Same? Pediatr Gastroenterol Hepatol Nutr. 2021 Jan;24(1):38-44. doi: 10.5223/pghn.2021.24.1.38. Epub 2021 Jan 8. PMID: 33505892; PMCID: PMC7813575. Go to original source... Go to PubMed...

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