Pediatr. praxi. 2024;25(4):253-256 | DOI: 10.36290/ped.2024.049
Simultaneous diagnosis of acute lymphoblastic leukemia and ganglioneuroma of the posterior mediastinum in an 11-year-old girl
- 1 Ústav molekulární a translační medicíny LF UP a FN v Olomouci
- 2 Dětská klinika LF UP a FN v Olomouci
- 3 Radiologická klinika LF UP a FN v Olomouci
- 4 Ústav patologické a molekulární medicíny LF UP a FN v Olomouci
- 5 Ústav lékařské genetiky FN Olomouc
- 6 Neurochirurgická klinika LF UP a FN v Olomouci
Ganglioneuroma is a rare, benign, terminally differentiated and slow-growing tumour of the autonomic nervous system, usually arising from sympathetic ganglion cells. Most are asymptomatic and found incidentally. We report a relatively rare case of a ganglioneuroma of the posterior mediastinum that was diagnosed simultaneously on initial imaging in an 11-year-old girl with acute lymphoblastic leukemia (ALL). Histopathological and histochemical examination of biopsy specimens confirmed the diagnosis of ganglioneuroma. Because of an asymptomatic course, without tumor propagation into the spinal canal, a non-operative management by imaging follow-up was chosen. The girl with acute leukemia is in complete remission, on maintenance treatment according to the AIEOP-BFM ALL 2017 protocol. The control chest MRI after 10 months confirmed the stationary character of GN without progression.
Keywords: school-age child, acute lymphoblastic leukemia, ganglioneuroma, posterior mediastinum, simultaneous presentation.
Accepted: August 27, 2024; Published: September 5, 2024 Show citation
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